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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Breast Cancer and Pregnancy: Clinical, Translational, and Psychosocial Perspectives

edited by

Alba Di Leone

and

Elena Jane Mason

submission deadline 30 Sep 2026 | 1 articles | Viewed by 332 | Submission Open

Keywords: pregnancy-associated breast cancer; postpartum breast cancer; pregnancy after breast cancer; oncofertility; fertility preservation; breast surgery; maternal outcomes; fetal outcomes; genetic risk; survivorship

(This special issue belongs to the Section Clinical Research of Cancer)

Artificial Intelligence (AI), Robotics, and Cancer Surgery

edited by Zaid M. Abdelsattar

submission deadline 30 Sep 2026 | Viewed by 266 | Submission Open

Keywords: cancer surgery; artificial intelligence; robotics surgery; surgical outcome; decision-making

(This special issue belongs to the Section Methods and Technologies Development)

Cancer Immunotherapy-Related Adverse Events and Therapy-Related Accelerated Aging

edited by

Grace Lu-Yao

submission deadline 30 Sep 2026 | Viewed by 201 | Submission Open

Keywords: immune-related adverse events (irAEs); accelerated aging; immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Cancer Drug Resistance: Mechanisms and Overcoming Strategies

edited by

Jessica M. Konen

submission deadline 30 Sep 2026 | Viewed by 154 | Submission Open

Keywords: intrinsic resistance; acquired resistance; targeted therapy resistance; combination treatment strategies; immunotherapy resistance; tumor heterogeneity

(This special issue belongs to the Section Clinical Research of Cancer)

The Development of Effective Therapy Targeting the Microenvironment of Cancer (2nd Edition)

edited by

Moriaki Kusakabe

and Kanae Taruno

submission deadline 30 Sep 2026 | 1 articles | Viewed by 152 | Submission Open

Keywords: cancer; tumor microenvironment; cancer therapy; cancer cell; animal level

(This special issue belongs to the Section Tumor Microenvironment)

Tumor-Initiating Cells in Cancer: Their Interactions with Other Cell Types, and Prospective Applications

edited by

Spiros Vlahopoulos

submission deadline 30 Sep 2026 | Viewed by 142 | Submission Open

Keywords: cancer stem cells; cancer stem-like cells; leukemia; chromatin; transcription factors; cellular phenotype; microenvironment; immunity; tumor stroma

(This special issue belongs to the Section Tumor Microenvironment)

Pediatric Surgery in Oncology: Innovations, Challenges, and Future Directions

edited by Abdelhafeez H. Abdelhafeez and Kokila Lakhoo

submission deadline 30 Sep 2026 | Viewed by 142 | Submission Open

Keywords: pediatric surgical oncology; intraoperative image guidance; minimally invasive surgery; fluorescence guidance; augmented reality; precision cancer surgery

(This special issue belongs to the Section Pediatric Oncology)

Medical Image-Based Cervical Cancer Prevention, Diagnosis, and Treatment

edited by Emma R. Allanson and Ming Yin Lin

submission deadline 30 Sep 2026 | Viewed by 126 | Submission Open

Keywords: medical imaging; 3-dimensional imaging; cervical cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Senescence and Cell Plasticity in Cancer Development

edited by

Eva María Verdugo-Sivianes

and Elena Aguado-Domínguez

submission deadline 30 Sep 2026 | Viewed by 120 | Submission Open

Keywords: cellular senescence; cell plasticity; stem cells; SASP; therapy resistance; tumor microenvironment; cancer development

(This special issue belongs to the Section Molecular Cancer Biology)

Psychological Factors and Cancer Survivorship

edited by

Deidre B. Pereira

and Ashley P. Ghiaseddin

submission deadline 30 Sep 2026 | Viewed by 109 | Submission Open

Keywords: psycho-oncology; distress; distress management; biobehavior markers and mechanisms; quality of life outcomes; treatment outcomes; survival outcomes

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Combination Therapy for Lymphoma

edited by

Maria Christina Cox

submission deadline 30 Sep 2026 | Viewed by 103 | Submission Open

Keywords: lymphoma; combination therapies; T-cell engagers; immuno-conjugates; targeted drugs

(This special issue belongs to the Section Cancer Therapy)

Pre-Clinical Studies of Personalized Medicine for Cancer Research: 2nd Edition

edited by

Nuno Vale

submission deadline 30 Sep 2026 | Viewed by 103 | Submission Open

Keywords: patient-derived models; genomic profiling; drug screening; biomarker validation; combination therapies; mechanistic studies; tumor heterogeneity; data analysis and interpretation

(This special issue belongs to the Section Molecular Cancer Biology)

Beyond PEGylation: Next-Generation Nanomedicine for Cancer Therapy

edited by

Soumen Saha

submission deadline 30 Sep 2026 | Viewed by 100 | Submission Open

Keywords: nanomedicine; tumor-targeting mechanisms; cancers

(This special issue belongs to the Section Tumor Microenvironment)

Redefining Precision Radiotherapy

edited by Srinivasan Vijayakumar

submission deadline 30 Sep 2026 | Viewed by 96 | Submission Open

Keywords: precision radiotherapy; cancer radiotherapy; PRT; RadioTheronostics

(This special issue belongs to the Section Methods and Technologies Development)

Integrated Palliative Care in Advanced Cancer

edited by

Sebastiano Mercadante

submission deadline 30 Sep 2026 | Viewed by 95 | Submission Open

Keywords: integrated palliative care; advanced cancer; cancer pain; symptom management; early integration; supportive care; end-of-life care; patient-centered outcomes; tele-palliative care; refractory symptoms

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

CRLM in the Era of Transplant Oncology: New Hope, New Questions

edited by Brian Davidson and

Khurum Khan

submission deadline 30 Sep 2026 | Viewed by 93 | Submission Open

Keywords: colorectal cancer; liver transplant; transplant oncology; chemotherapy; immunotherapy; immunosuppression; genetic profiling; circulating ccDNA; staging; surveillance

(This special issue belongs to the Section Cancer Therapy)

Current Status of Neuroendocrine Tumors with a Special Focus on Diagnosis and Novel Treatments—3rd Edition

edited by

Dan Granberg

submission deadline 30 Sep 2026 | Viewed by 89 | Submission Open

Keywords: neuroendocrine tumors; somatostatin analogues; PRRT; chemotherapy; 68Gallium-DOTATOC; PET; CT; targeted therapies; mTOR; inhibitors; angiogenesis

(This special issue belongs to the Section Cancer Therapy)

Extracellular Matrix Proteins in Cancer (2nd Edition)

edited by

Dragana Nikitovic

and Aikaterini Berdiaki

submission deadline 30 Sep 2026 | Viewed by 89 | Submission Open

Keywords: extracellular matrix (ECM); tumor microenvironment (TME); stromal remodeling; cancer-associated fibroblasts (CAFs); fibrous proteins; mechanotransduction; interstitial fluid pressure; proteoglycans and glycoproteins; matrix crosslinking; epithelial-to-mesenchymal transition (EMT); angiogenesis; matrikines; therapy resistance

(This special issue belongs to the Section Tumor Microenvironment)

Hematologic Malignancies: Clinical Features and Prognostic Indicators

edited by Danijela Leković

submission deadline 30 Sep 2026 | Viewed by 89 | Submission Open

Keywords: leukemia; myelodysplastic syndrome; myeloproliferative neoplasms; lymphoma; multiple myeloma; diagnosis; prognosis; molecular markers; infections; survival; machine learning

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Clinical Trials and Precision Medicine for Neuro-Oncology

edited by Malaka Ameratunga

submission deadline 30 Sep 2026 | Viewed by 88 | Submission Open

Keywords: clinical trials; neuro-oncology; precision oncology; molecular targets; precision medicine

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Pathogenesis and Pathology Diagnosis of Gynecologic Cancers

edited by

Wenxin Zheng

submission deadline 30 Sep 2026 | Viewed by 87 | Submission Open

Keywords: gynecologic cancers; molecular pathology; tumor pathogenesis; diagnostic biomarkers; precision medicine; endometrial carcinoma; ovarian cancer; cervical cancer; histopathology; translational research

New Era of Systemic Therapy for Different Types of Skin Cancer

edited by Magdalena Ciazynska

submission deadline 30 Sep 2026 | Viewed by 79 | Submission Open

Keywords: skin cancer systemic therapy; immunotherapy in skin cancer; targeted therapy in skin malignancies; melanoma and nonmelanoma skin cancer; biomarkers and treatment response; resistance mechanisms; combination therapy; real worldreal-world outcomes; novel therapeutic agents; precision oncology

(This special issue belongs to the Section Cancer Therapy)

Ablation Treatment for Malignant Tumors

edited by

Madelon Dijkstra

Martijn Meijerink

and

Susan Van Der Lei

submission deadline 30 Sep 2026 | Viewed by 78 | Submission Open

Keywords: ablative therapies; thermal ablation; image-guided therapy; minimally invasive; radiofrequency ablation (RFA); microwave ablation (MWA); cryoablation; irreversible electroporation (IRE); malignant tumors; oligometastatic disease; immunotherapy combinations; interventional oncology

(This special issue belongs to the Section Cancer Therapy)

The Tumor Microenvironment and Molecular Aberrations Convey Immune Evasion (Third Edition)

edited by

Huey-Jen Lin

submission deadline 30 Sep 2026 | Viewed by 74 | Submission Open

Keywords: CD8+ tumor-infiltrating lymphocytes; cytotoxic T lymphocytes -associated protein 4; dendritic cells; immune evasion; hypoxia-inducible factors; myeloid-derived suppressor cells; natural killer; programmed death receptor and ligand; regulatory T cells; tumor-associated macrophages; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Leukemia Stem Cells: Persistence, Resistance, and Novel Eradication Strategies

edited by Elisa Donato and Darja Karpova

submission deadline 30 Sep 2026 | Viewed by 72 | Submission Open

Keywords: leukemia stem cells (LSCs); acute myeloid leukemia (AML); therapeutic resistance; minimal residual disease (MRD); LSC quiescence; cellular therapy; hematopoietic stem cell transplantation (HSCT); LSC microenvironment

PSMA Targeted Strategies and Radioligand Therapies in Prostate Cancer: From Preclinical Models to Clinical Translation

edited by Neha Vapiwala and John Nikitas

submission deadline 30 Sep 2026 | Viewed by 69 | Submission Open

Keywords: prostate cancer; prostate-specific membrane antigen; radioligand therapy; radiopharmaceutical therapy; radiotherapy; theranostics

(This special issue belongs to the Section Cancer Therapy)

Translational Advances in Reproductive Cancers: From Targets to Therapies

edited by

Kamila Domińska

submission deadline 30 Sep 2026 | Viewed by 65 | Submission Open

Keywords: reproductive cancers; signal transduction pathways; hormonal regulation; targeted therapy; therapeutic limitations

(This special issue belongs to the Section Molecular Cancer Biology)

The Cellular Ecosystem of Cancer: New Insights into Cell Biology

edited by Xiaochao Tan and

Guan-Yu Xiao

submission deadline 30 Sep 2026 | Viewed by 65 | Submission Open

Keywords: cell organelle; ER; mitochondria; lysosome; Golgi; secretion; tumor microenvironment

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Clinical Pharmacology in Lung Cancer—2nd Edition

edited by

Chih-Jen Yang

submission deadline 30 Sep 2026 | Viewed by 60 | Submission Open

Keywords: lung cancer; target therapy; immunotherapy; antiangiogenic agent; chemotherapy; NGS

(This special issue belongs to the Section Cancer Drug Development)

New Clinical Insights into Gynecological Malignancies

edited by

Amelia Jernigan

submission deadline 30 Sep 2026 | Viewed by 60 | Submission Open

Keywords: innovative care; data science; precision medicine; uterine cancer; ovarian cancer; vulvar cancer; vaginal cancer

(This special issue belongs to the Section Cancer Therapy)

Health-Related Quality of Life in Cancer Survivorship

edited by Deniz Gencer and Elisabeth Coyne

submission deadline 30 Sep 2026 | Viewed by 59 | Submission Open

Keywords: cancer survivorship; health-related quality of life (HRQoL); interventions; psychological support; personalized care; educational resources

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Clinical Trials and Translational Research in Multiple Myeloma

edited by Laszlo Varoczy

submission deadline 30 Sep 2026 | Viewed by 53 | Submission Open

Keywords: multiple myeloma; disease evolution; translational research; personalizing therapy; clinical trial

(This special issue belongs to the Section Clinical Research of Cancer)

Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy, and Beyond in Peritoneal Disease: Advancing Clinical Care and Therapeutics

edited by

Benjamin D. Powers

submission deadline 30 Sep 2026 | Viewed by 48 | Submission Open

Keywords: peritoneal surface malignancies; peritoneal carcinomatosis; colorectal cancer; appendiceal cancer; pseudomyxoma peritonei; ovarian cancer; mesothelioma; gastric cancer; small bowel cancer; cytoreductive surgery; HIPEC; PIPAC; photodynamic therapy; chemotherapy; chemoresistance; novel therapies; rare diseases

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in Myeloma: From Molecular Pathways to Drug Development

edited by Natalia Neparidze

submission deadline 30 Sep 2026 | Viewed by 46 | Submission Open

Keywords: myeloma; plasma cell disorders; monoclonal gammopathy; bispecifics; T cell engagers; CART therapy; monoclonal antibodies; MRD

(This special issue belongs to the Section Cancer Drug Development)

Pancreatic Cancer Ultrasound: A Problem-Based Approach

edited by

Carla Serra

and Andrea Boccatonda

submission deadline 30 Sep 2026 | Viewed by 42 | Submission Open

Keywords: cancer; ultrasound; pancreas; CEUS; malignancy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Cancer and Melatonin: Updates on Current Findings

edited by

Rita Rezzani

submission deadline 30 Sep 2026 | Viewed by 14 | Submission Open

Keywords: cancer; melatonin; oxidative stress; inflammation; antioxidant defense

Cell Cycle Dysregulation in Cancers

edited by Radoslav Janostiak

submission deadline 30 Sep 2026 | Viewed by 12 | Submission Open

Keywords: cell cycle regulation; proliferation-quiescence decision; post translational regulation; quiescence maintenance; senescence escape; environmental stress adaptation; minimal residual disease; cell cycle checkpoints

(This special issue belongs to the Section Molecular Cancer Biology)

Head and Neck Cancer Recurrence: Diagnosis, Treatment and Prognosis (2nd Edition)

edited by

Oreste Gallo

submission deadline 10 Oct 2026 | 1 articles | Viewed by 1555 | Submission Open

Keywords: head and neck cancer; recurrence; squamous cell carcinoma; HPV; larynx; oral cavity; oropharynx

(This special issue belongs to the Section Cancer Therapy)

Multidisciplinary Advances and Surgical Impact in Brain and Central Nervous System Tumors: From Molecular Insights to Clinical Outcomes

edited by Paolo Tini, Salvatore Chibbaro and

Mario Ganau

submission deadline 10 Oct 2026 | Viewed by 55 | Submission Open

Keywords: glioblastoma; low-grade gliomas; ependymomas; PNET; meningiomas; medulloblastomas; other brain tumors

Outcomes in Glioblastoma Patients: From Diagnosis to Palliation: 2nd Edition

edited by

Alba Scerrati

and Giorgio Mantovani

submission deadline 15 Oct 2026 | 1 articles | Viewed by 654 | Submission Open

Keywords: high-grade glioma; outcome assessment; prognostic factors; neuro-oncology; glioblastoma

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Cancer Rehabilitation and Physical Activity: Advancing Function, Recovery, and Quality of Life Across the Cancer Continuum

edited by Jennifer Michelle Jones

submission deadline 15 Oct 2026 | Viewed by 82 | Submission Open

Keywords: cancer rehabilitation; exercise science; physical activity; prehabilitation; adverse side effects

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

The Robotic Revolution in Endometrial Cancer: Advancing Surgical Staging and Patient Care

edited by Roberto Berretta

submission deadline 20 Oct 2026 | Viewed by 101 | Submission Open

Keywords: endometrial cancer; robotic surgery; minimally invasive surgery; gynecologic oncology; surgical innovation; obesity; surgical staging; uterine cancer; lymphadenectomy; sentinel node mapping

(This special issue belongs to the Section Cancer Therapy)

The Future of Precision Radiotherapy for Cancer: Technology, Optimization, and Clinical Integration

edited by Thomas J. Fitzgerald

submission deadline 20 Oct 2026 | Viewed by 84 | Submission Open

Keywords: radiation; proton; photon; brachytherapy

(This special issue belongs to the Section Methods and Technologies Development)

Radiation Therapy for Brain Tumors

edited by

Jim Zhong

submission deadline 25 Oct 2026 | 4 articles | Viewed by 12510 | Submission Open

Keywords: radiosurgery; hypofractionated radiosurgery; spectroscopic MRI; proton radiation; image-guided radiotherapy; radiotherapy for benign tumors; radiotherapy for gliomas; gamma knife

(This special issue belongs to the Section Cancer Therapy)

The Future of Machine Learning in Predicting Cancer Treatment Response

edited by

Gholamreza Rafiee

submission deadline 25 Oct 2026 | Viewed by 60 | Submission Open

Keywords: machine learning; genomic language models; multiomics integration; enhancer prediction; interpretable AI; tumour stratification; deep learning; translational oncology; cancer treatment response

(This special issue belongs to the Section Methods and Technologies Development)

Gynecological Cancers: From Bench to Bedside

edited by

Francesco Cosentino

submission deadline 30 Oct 2026 | 1 articles | Viewed by 440 | Submission Open

Keywords: gynecologic oncology; translational research; molecular mechanisms; targeted therapy; immunotherapy; personalized medicine

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Clinical Research of Brachytherapy in Cancer

edited by Ludmiła Grzybowska-Szatkowska,

Paweł Cisek

and Aleksandra Kozłowska

submission deadline 30 Oct 2026 | 1 articles | Viewed by 289 | Submission Open

Keywords: brachytherapy; LDR; HDR; genitourinary cancers; breast cancer; skin cancer; gastrointestinal cancers; oligometastatic disease; personalized treatment and neoplasm

(This special issue belongs to the Section Clinical Research of Cancer)

Gynecologic Cancer: From Diagnosis to Treatment: 2nd Edition

edited by

Vito Andrea Capozzi

submission deadline 30 Oct 2026 | Viewed by 127 | Submission Open

Keywords: endometrial cancer; cervical cancer; ovarian cancer; borderline ovarian tumor; diagnosis and treatment

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Role of Sphingolipids in Cancer Progression

edited by

Jeremy Hengst

submission deadline 30 Oct 2026 | Viewed by 127 | Submission Open

Keywords: sphingolipids; tumorigenesis; tumor progression; metastasis; spatial transcriptomics; spatial metabolomics; spatial proteomics; transcriptomics; metabolomics; proteomics; drug development

(This special issue belongs to the Section Molecular Cancer Biology)

Cancer Prevention and Screening: Innovations, Implementation, and Access

edited by