Pseudokinases, Tribbles Proteins and Cancer

Dear Colleagues,

The “kinome” contains a significant proportion of pseudokinases. These proteins have a kinase-like domain but do not have (or have very low) kinase activity. Thus, pseudokinases play their physiological functions via protein–protein interactions. Several members of this family of proteins have been implicated in the regulation of the signaling through tyrosine kinase receptors, LKB1/AMPK, AKT, or MAPKs, among other pathways involved in the regulation of cancer generation and progression. Specifically, Tribbles pseudokinases have attracted considerable attention during the last decade due to their ability to regulate inflammation, metabolism, and cancer through the control of some of the above signaling pathways. 

This Special Issue is devoted to investigations that focus on the role of pseudokinases, and especially of Tribbles proteins, in cancer. Original articles and reviews covering different aspects such as the analysis of the role of pseudokinases in cancer and cancer-associated stromal cells; the role of pseudokinases in the resistance or sensitivity to anticancer agents; the association between changes in the expression (or alterations in the genes encoding) pseudokinases and the generation and progression of certain cancer types; or the development of anticancer strategies based on the pharmacological modulation of the interaction of pseudokinases with some of their targets are welcome.

Dr. Guillermo Velasco
Dr. Wolfgang Link
Guest Editors

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