Topical Collection "Regulatory and Non-Coding RNAs in Cancer Epigenetic Mechanisms"

Editor

Prof. Dr. Nicoletta Sacchi
E-Mail Website
Guest Editor
Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA
Interests: genome wide epigenetic control of transcription;transcription factors and nuclear receptors; regulatory RNAs
Special Issues and Collections in MDPI journals

Topical Collection Information

Dear Colleagues,

Over the years enormous progress has been made in our understanding of the way RNA controls and regulates processes in cells and organisms, and how these mechanisms—when they go awry—contribute to the progression of many diseases, including cancer. The regulatory and non-coding “RNA world” includes not only long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) but also many more other types of RNAs (e.g., circular RNAs, enhancer RNAs) that are components of epigenetic regulatory mechanisms of development and cancer. The objective of this collection is to attract research studies and critical reviews on the central role of regulatory and non-coding RNAs in epigenetic mechanisms of cancer.

Prof. Dr. Nicoletta Sacchi
Guest Editor

Manuscript Submission Information

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Keywords

  • long non-coding RNAs
  • microRNAs
  • circular RNAs
  • epigenetics
  • development
  • cancer

Published Papers (1 paper)

2019

Open AccessReview
MicroRNA Regulation of Epigenetic Modifiers in Breast Cancer
Cancers 2019, 11(7), 897; https://doi.org/10.3390/cancers11070897 - 27 Jun 2019
Cited by 1
Abstract
Epigenetics refers to the heritable changes in gene expression without a change in the DNA sequence itself. Two of these major changes include aberrant DNA methylation as well as changes to histone modification patterns. Alterations to the epigenome can drive expression of oncogenes [...] Read more.
Epigenetics refers to the heritable changes in gene expression without a change in the DNA sequence itself. Two of these major changes include aberrant DNA methylation as well as changes to histone modification patterns. Alterations to the epigenome can drive expression of oncogenes and suppression of tumor suppressors, resulting in tumorigenesis and cancer progression. In addition to modifications of the epigenome, microRNA (miRNA) dysregulation is also a hallmark for cancer initiation and metastasis. Advances in our understanding of cancer biology demonstrate that alterations in the epigenome are not only a major cause of miRNA dysregulation in cancer, but that miRNAs themselves also indirectly drive these DNA and histone modifications. More explicitly, recent work has shown that miRNAs can regulate chromatin structure and gene expression by directly targeting key enzymes involved in these processes. This review aims to summarize these research findings specifically in the context of breast cancer. This review also discusses miRNAs as epigenetic biomarkers and as therapeutics, and presents a comprehensive summary of currently validated epigenetic targets in breast cancer. Full article
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