Advances in Deep Brain Stimulation for Movement Disorders
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".
Deadline for manuscript submissions: closed (15 October 2022) | Viewed by 4729
Special Issue Editor
Special Issue Information
Dear Colleagues,
Following decades of hibernation during the early levodopa era of Parkinson’s disease, the development of implantable devices to chronically stimulate brain structures ignited a renaissance in the neurosurgical treatment of over 50 brain disorders using more than 30 targets. Most published literature is in relation to Parkinson’s disease, tremor disorders, and dystonia. The attraction of this procedure is in both its capacity to probe pathological brain networks and deliver reversible and adjustable therapy. Even as the focus of research slightly shifts towards other neurological and psychiatric disorders, there remains a hopeful landscape of innovation to overcome the limitations and challenges of deep brain stimulation (DBS) in movement disorders, e.g.: resource intensiveness, relative lack of efficacy in axial symptoms, freezing of gait, speech, affective, and cognitive problems in Parkinson’s disease; habituation and the emergence of ataxia and dysarthria in essential tremor; and ideal patient and target selection in dystonia. These innovations include advances in the control of DBS, e.g., closed loop adaptive systems, the pattern of DBS, e.g., variable frequency or burst stimulation paradigms, electrode and implantable pulse generator (IPG) design, a connectomic and personalised approach to DBS and the development of artificial intelligence and remote systems for DBS programming. This landscape is explored in a series of articles in this Special Issue.
Prof. Dr. Dominic Thyagarajan
Guest Editor
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Keywords
- movement disorders
- Parkinson's disease
- tremor disorders
- dystonia
- Deep Brain Stimulation
- DBS
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