Advances in Immune-Mediated Disorders of the Nervous System in Childhood

Dear Colleagues,

In recent years, our understanding of immune-mediated disorders affecting the pediatric nervous system has significantly evolved. From classical autoimmune encephalitides to novel neuroinflammatory syndromes, these conditions pose unique diagnostic and therapeutic challenges in children. Early recognition and appropriate treatment are critical for improving long-term outcomes, yet the heterogeneity in clinical presentation, biomarkers, and treatment responses demands a multidisciplinary approach. This Special Issue aims to bring together the latest advances in the field, including new insights into pathophysiological mechanisms, updates on diagnostic criteria, innovative immunotherapeutic strategies, and emerging biomarkers. Contributions will cover a broad spectrum of disorders such as autoimmune encephalitis, pediatric multiple sclerosis, MOGAD, neuromyelitis optica spectrum disorder, and parainfectious or post-vaccinal syndromes. We invite original research, case series, and reviews that enhance our understanding and management of immune-mediated neurological diseases in childhood, with the goal of supporting early diagnosis, precision treatment, and improved quality of life for affected patients.

Prof. Dr. Martino Ruggieri
Dr. Andrea Domenico Praticò
Guest Editors

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