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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Feature Reviews in Tumor Immunology

edited by

Maria-Ioanna Christodoulou

submission deadline 31 Oct 2025 | 2 articles | Viewed by 5210 | Submission Open

Keywords: tumor immunity; immunotherapy; engineered immune cells; antibodies; immunomodulators; cytokines; survival; immune-checkpoint inhibitors; tumor immune microenvironment

(This special issue belongs to the Section Immunology and Immunotherapy)

Progress in Neonatal Pulmonary Biology

edited by

Fumihiko Namba

submission deadline 31 Oct 2025 | 2 articles | Viewed by 5107 | Submission Open

Keywords: neonate; preterm infant; bronchopulmonary dysplasia; animal model; in vivo model; in vitro model; basic research; translational research; respiratory outcome; neurodevelopmental outcome

(This special issue belongs to the Section Molecular and Translational Medicine)

Epigenetic Regulation and Its Impact for Medicine (2nd Edition)

edited by

Marie Černá

submission deadline 31 Oct 2025 | 3 articles | Viewed by 4996 | Submission Open

Keywords: gene expression; DNA methylation; histone modifications; non-coding RNAs; biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Pathogenesis and Therapeutics of Gastrointestinal Diseases

edited by

Jinghua Wang

submission deadline 31 Oct 2025 | 2 articles | Viewed by 4344 | Submission Open

Keywords: gastrointestinal diseases; IBD; IBS; GERD; functional dyspepsia; gut microbiome

(This special issue belongs to the Section Molecular and Translational Medicine)

Gynecological Diseases in Cellular and Molecular Perspectives

edited by

Iwona Wertel

and

Anna Pawłowska-Łachut

submission deadline 31 Oct 2025 | 3 articles | Viewed by 4329 | Submission Open

Keywords: gynaecological diseases; endometriosis; biomarkers; immune checkpoints; immunotherapy; tumor microenvironment; tumor-infiltrating immune cells; cancer immunology; cellular interactions

(This special issue belongs to the Section Molecular and Translational Medicine)

Musculoskeletal Diseases: From Molecular Basis to Therapy—3rd Edition

edited by

Elisa Belluzzi

and

Assunta Pozzuoli

submission deadline 31 Oct 2025 | 4 articles | Viewed by 4314 | Submission Open

Keywords: musculoskeletal diseases; bone cancer; soft tissue cancer; bone metastasis; natural compounds; anticancer drugs; osteoarthritis; joint tissues; biomarkers; inflammation; microRNAs; exosomes

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Liver Oncology: Molecular Mechanisms and Therapeutic Innovations

edited by

Rui Caetano Oliveira

, Rui Miguel Martins and

José Guilherme Tralhão

submission deadline 31 Oct 2025 | 3 articles | Viewed by 4295 | Submission Open

Keywords: liver cancer; hepatocellular carcinoma; cholangiocarcinoma; liver metastases; tumor microenvironment; targeted therapy; immunotherapy; biomarkers; drug resistance

(This special issue belongs to the Section Cancer Biology and Oncology)

Pathogenesis, Diagnosis, and Treatment of Respiratory Diseases

edited by

Te-Chun Shen

submission deadline 31 Oct 2025 | 3 articles | Viewed by 4124 | Submission Open

Keywords: COPD; asthma; interstitial lung disease; lung cancer; pneumonia; tuberculosis; respiratory failure; ARDS; COVID-19; obstructive sleep apnea

(This special issue belongs to the Section Cell Biology and Pathology)

Trends in 3D Printing Processes for Biomedical Field: Opportunities and Challenges (2nd Edition)

edited by

M. R. Mozafari

submission deadline 31 Oct 2025 | 1 articles | Viewed by 4050 | Submission Open

Keywords: 3D/4D bioprinting techniques; 3D bioprinting processes; 3D cellular microenvironment; bio-inks; hydrogels

(This special issue belongs to the Section Biomedical Engineering and Materials)

Renin-Angiotensin System in Cardiovascular Biology, 2nd Edition

edited by

Mária Szekeres

György L. Nádasy

and

László Dézsi

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3903 | Submission Open

Keywords: renin– angiotensin system (RAS); signaling mechanisms of angiotensin receptors; GPCR; AT1R; AT2R; ACE; ACE2; ACEI; angiotensin II; signal transduction; cardiovascular system; hypertension; atherosclerosis; heart failure; cardiovascular remodeling; osmoregulation; inflammation

(This special issue belongs to the Section Molecular and Translational Medicine)

Sphingolipid Metabolism and Signaling in Health and Diseases: 2nd Edition

edited by

Giulia Lunghi

Elena Chiricozzi

and

Maria Fazzari

submission deadline 31 Oct 2025 | 2 articles | Viewed by 3080 | Submission Open

Keywords: sphingolipids; glycosphingolipids; gangliosides; sphingosine-1-phosphate; cell homeostasis; neurodegeneration; neurodevelopment; inflammation; diabetes; cystic fibrosis; cancer

(This special issue belongs to the Section Cell Biology and Pathology)

Vitamin D: Latest Scientific Discoveries in Health and Disease

edited by

Mohamed Abouzid

submission deadline 31 Oct 2025 | 2 articles | Viewed by 3012 | Submission Open

Keywords: vitamin D; vitamin D metabolites; metabolic pathways; vitamin D receptor; polymorphisms; pathogenesis; vitamin D deficiency

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Oxidative Stress and Inflammation: From Mechanisms to Therapeutic Approaches (4th Edition)

edited by

Juan Gambini

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2872 | Submission Open

Keywords: oxidative stress; inflammation; molecular mechanisms; pharmacotherapy; longevity; aging

(This special issue belongs to the Section Immunology and Immunotherapy)

Innovative Approaches in In Vitro Skin Models: From Design to Application

edited by

Tina Maver

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2783 | Submission Open

Keywords: in vitro skin models; tissue engineering; dermatological research; 3D skin bioprinting; skin disease modeling

(This special issue belongs to the Section Biomedical Engineering and Materials)

MicroRNA and Its Role in Human Health, 2nd Edition

edited by

Shih-Yao Chen

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2617 | Submission Open

Keywords: microRNA; disease models; disease associations; molecular mechanism; molecular diagnosis; molecular therapy

(This special issue belongs to the Section Cell Biology and Pathology)

Recent Developments in Mycobacterial Research

edited by

Vishwanath Venketaraman

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2546 | Submission Open

Keywords: Mycobacterium tuberculosis; mycobacterial; host immune responses

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Convergence of Allergology and Immunology: Unveiling Mechanistic Insights

edited by

Kinga Lis

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2081 | Submission Open

Keywords: allergy; hypersensitivity; allergens; immunological mechanisms; immunological diagnostics; immunotherapy

(This special issue belongs to the Section Immunology and Immunotherapy)

Cardiac and Vascular Diseases: Pathogenesis, Pharmacological Treatments, Advances in Therapies (3rd Edition)

edited by

Francesco Massari

and

Pietro Scicchitano

submission deadline 31 Oct 2025 | 3 articles | Viewed by 2062 | Submission Open

Keywords: endothelial function; cardiomyopathies; cardiovascular pharmacology; cardiac therapeutics; noninvasive vascular treatments; molecular cardiac biomarkers; molecular vascular biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

Protein Misfolding and Functional Impairment in Neurodegenerative Diseases

edited by

Marios Krokidis

Themis Exarchos

and

Panayiotis Vlamos

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2054 | Submission Open

Keywords: protein misfolding; chaperones; energy landscape; neurodegenerative diseases; amyloidogenesis; intrinsically disordered proteins; structure prediction algorithms; bioinformatics; molecular dynamic simulations

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Latest Advancements in Radiotherapy

edited by

Moshi Geso

submission deadline 31 Oct 2025 | 3 articles | Viewed by 2049 | Submission Open

Keywords: radiobiology; dosimetry; nanoparticles; FLASH; radiation

(This special issue belongs to the Section Molecular and Translational Medicine)

Prostate Cancer Targeted Therapy: Highlighting Advances in Precision Medicine and Rational Combination Approaches

edited by Alan P. Lombard

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1983 | Submission Open

Keywords: prostate cancer; precision medicine; targeted therapeutics; rational drug combinations; clinical biomarkers

(This special issue belongs to the Section Cancer Biology and Oncology)

Emerging Therapeutic Strategies for Epilepsy: Bridging Research and Clinical Practice

edited by Tanveer Singh

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1837 | Submission Open

Keywords: epilepsy; status epilepticus; MRI; EEG; inhibitory neurotransmission; immunohistochemistry; gene regulation; neurodegeneration; precision medicine

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Hepatocellular Carcinoma Pathogenesis and Therapy

edited by Junyan Tao

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1767 | Submission Open

Keywords: HCC (hepatocellular carcinoma); early diagnosis; molecular pathology characteristics; molecular target therapy; combination therapy; immune checkpoint inhibitors; precision medicine; HCC heterogeneity; drug resistance; HCC risk factors

(This special issue belongs to the Section Cancer Biology and Oncology)

Advanced Research in Secondary Immunodeficiency in Oncohematological Diseases

edited by

Giuseppe Murdaca

and

Sebastiano Gangemi

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1759 | Submission Open

Keywords: secondary immunodeficiencies and opportunistic infections; secondary immunodeficiencies and B-lymphocytes; secondary immunodeficiencies and hematological diseases; secondary immunodeficiencies and cancers; secondary immunodeficiencies and novel cancer treatments; secondary immunodeficiencies and oxidative stress

(This special issue belongs to the Section Immunology and Immunotherapy)

Unraveling New Horizon in Vascular Diseases: From Pathophysiology to Novel Therapeutic

edited by Miguel A. Ortega and

Raul Diaz-Pedrero

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1748 | Submission Open

Keywords: vascular diseases; artery; venous disease; venous hypertension; heart; lymph; diabetes; surgery; immune system; translational medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Sex Hormones and Cardiovascular Diseases: From Pathophysiology to Novel Therapeutic Approaches

edited by

Renáta Szabó

and

Denise Börzsei

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1610 | Submission Open

Keywords: endogenous sex hormones; aging; sexual dimorphism; hormone replacement therapy; CVDs; hypertension; myocardial infarction; atherosclerosis

(This special issue belongs to the Section Molecular and Translational Medicine)

Role of Endothelial Cells in Cardiovascular Disease—2nd Edition

edited by

Lorenzo Falsetti

and

Vincenzo Zaccone

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1547 | Submission Open

Keywords: endothelial cells; endothelial dysfunction; cardiovascular disease; endothelial progenitor cells; atherosclerosis; thrombosis; vessel inflammation; regenerative medicine

(This special issue belongs to the Section Cell Biology and Pathology)

Biological Role of Oxidative Stress in Inflammatory Processes

edited by

Magdalena Paulina Kasprzak

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1462 | Submission Open

Keywords: oxidative stress; redox balance; antioxidants; NRF2; microbiota; bilirubin; Tlr4; inflammation

(This special issue belongs to the Section Cell Biology and Pathology)

Glioma Therapy: Current Status and Future Prospects

edited by Bernd Kaina

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1416 | Submission Open

Keywords: glioblastoma; temozolomide; nitrosoureas; immunotherapy; biologicals; tyrosine kinase inhibitors; senotherapeutics

(This special issue belongs to the Section Cancer Biology and Oncology)

New Molecular Insights into the Pathogenesis and Drug Development of Neurodegenerative Diseases: 2nd Edition

edited by Aifang Cheng, Beika Zhu and Fulin Ma

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1357 | Submission Open

Keywords: neurodegenerative diseases; pathogenesis; molecular mechanisms; high-throughput drug screening; drug repurposing; cellular and animal models; brain organoids; mode of action; pharmacological evaluations; preclinical study

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advanced Research in Anticancer Inhibitors and Targeted Therapy

edited by

Changmin Peng

and

Hassan Ebrahim

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1356 | Submission Open

Keywords: histone deacetylases (HDACs); YAP signaling; targeted therapy; oncogenic signaling; biomarker discovery; small-molecule inhibitors; cancer drug resistance; epigenetic therapy

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Advances in Heparan Sulfate Biology: Protein Interactions and Therapeutic Implications

edited by Miaomiao Li

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1320 | Submission Open

Keywords: heparan sulfate; heparin; heparanase; heparan sulfate-binding protein; heparan sulfate oligosaccharides; antibody; natural sulfated carbohydrates

(This special issue belongs to the Section Cell Biology and Pathology)

Updates on Kawasaki Disease

edited by Eisuke Suganuma

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1288 | Submission Open

Keywords: coronary artery aneurysm; cluster; individualized treatment

(This special issue belongs to the Section Molecular and Translational Medicine)

Male Reproductive Medicine: From Basic to Clinical Research

edited by Donghui Huang

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1147 | Submission Open

Keywords: male reproductive function; spermatogenesis; hormonal regulation; genetic and epigenetic influences; environmental toxicology; male reproductive health

(This special issue belongs to the Section Molecular and Translational Medicine)

The Molecular Mechanisms of Hearing, Balance and Deafness

edited by

Francisco J. del Castillo

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1128 | Submission Open

Keywords: hearing; balance; deafness; molecular mechanisms; genetics; transcriptomics

(This special issue belongs to the Section Molecular and Translational Medicine)

Allergic Rhinitis: From Pathology to Novel Therapeutic Approaches

edited by

Shaoqing Yu

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1114 | Submission Open

Keywords: allergic rhinitis; immunotherapy; immune mechanisms in allergy; rhinitis biomarkers

(This special issue belongs to the Section Immunology and Immunotherapy)

Strategies for Anticancer in p53 Mutated Cancers

edited by

Bi-He Cai

and

Ching-Feng Lien

submission deadline 31 Oct 2025 | 1 articles | Viewed by 916 | Submission Open

Keywords: p53; p63; p73; tumor suppressor gene; microRNA; long non-coding RNA; protein degradation; heat shock proteins; mutation; oncology

(This special issue belongs to the Section Cancer Biology and Oncology)

Past, Present and Further Looking for Therapeutic Management of Pancreatic Ductal Adenocarcinoma (2nd Edition)

edited by

Gennaro Nappo

and

Niccola Funel

submission deadline 31 Oct 2025 | 1 articles | Viewed by 819 | Submission Open

Keywords: pancreatic cancer; pancreatic ductal adenocarcinoma; treatment pancreatic cancer; chemotherapy pancreatic cancer; radiotherapy pancreatic cancer; pancreatic cancer biology; PDAC preclinical model; biomolecular markers; theragnostic molecules; target therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Exploitation and Development of “Synthetic Lethality” Strategy for Cancer Therapy

edited by Guo Chen

submission deadline 31 Oct 2025 | Viewed by 696 | Submission Open

Keywords: anti-cancer therpies; PARP inhibitors; synthetic lethality

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Pancreatic, Liver, Biliary Tract and Intestinal Diseases: Pathogenesis, Diagnostics and Therapy—2nd Edition

edited by

Beata Jabłońska

and

Sławomir Mrowiec

submission deadline 31 Oct 2025 | 1 articles | Viewed by 640 | Submission Open

Keywords: inflammatory bowel disease; gastrointestinal tumor; gastrointestinal cancer; acute pancreatitis; chronic pancreatitis; pancreatic cyst; biliary cyst; liver disease; biliary tract disease

(This special issue belongs to the Section Molecular and Translational Medicine)

Tumor Microenvironment in Cancer: Basic Science, Artificial Intelligence, and Clinical Research

edited by Rada Amin

submission deadline 31 Oct 2025 | 1 articles | Viewed by 554 | Submission Open

Keywords: tumor microenvironment; cancer progression; malignancies; immunotherapy; therapy resistance; immune evasion

(This special issue belongs to the Section Cancer Biology and Oncology)

Gut–Brain Axis and Diabetes

edited by Nikolett Bódi

submission deadline 31 Oct 2025 | Viewed by 439 | Submission Open

Keywords: diabetes; gut– brain axis; enteric nervous system; central nervous system; microbiota; enteroendocrine cells; inflammation; immune responses

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Advances in Inflammatory Skin Diseases

edited by

Angelo Ruggiero

Luca Potestio

and

Matteo Megna

submission deadline 31 Oct 2025 | Viewed by 417 | Submission Open

Keywords: inflammatory skin diseases; pathophysiology; therapeutic strategies; novel treatments; skin disorders

(This special issue belongs to the Section Immunology and Immunotherapy)

Advances in Age-Related Diseases: Molecular Mechanisms, Treatments, and Clinical Implications

edited by

Stefano Cacciatore

and

Emanuele Marzetti

submission deadline 31 Oct 2025 | Viewed by 381 | Submission Open

Keywords: aging; age-related diseases; cellular senescence; mitochondrial dysfunction; inflammation and oxidative stress; biomarkers; precision medicine; pharmacological interventions; healthy aging; translational geriatric research

(This special issue belongs to the Section Molecular and Translational Medicine)

The Role of Oxidative Stress in Metabolic Syndrome

edited by

Bojlul Bahar

submission deadline 31 Oct 2025 | Viewed by 372 | Submission Open

Keywords: free radical; oxidative stress; ROS; NRF2; Keap1; metabolic syndrome; chronic inflammation; cardiovascular disease; obesity; diabetes

(This special issue belongs to the Section Molecular and Translational Medicine)

Unraveling the Epigenetic Blueprint: Exploring DNA Methylation and Its Integration with Omics in Health and Disease

edited by Priyadarshini Kachroo and Rinku Sharma

submission deadline 31 Oct 2025 | Viewed by 361 | Submission Open

Keywords: multiomics; networks; epigenomics; machine learning; causation; early-life exposures; aging; translational therapeutics; metabolomics; epigenomics; exposomics; proteomics; microbiome

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Epigenetic Regulation in Liver Metabolic Homeostasis and Disease

edited by Chengfei Jiang and Zhe Li

submission deadline 31 Oct 2025 | Viewed by 354 | Submission Open

Keywords: liver metabolism; epigenetic regulation; RNA modification; metabolic disorder; non-coding RNA; liver disease

(This special issue belongs to the Section Molecular and Translational Medicine)

Molecular Insights and Translational Approaches in Musculoskeletal Disorders

edited by Priyanka Kushwaha

submission deadline 31 Oct 2025 | Viewed by 342 | Submission Open

Keywords: musculoskeletal disorders; osteoarthritis; rheumatoid arthritis

(This special issue belongs to the Section Molecular and Translational Medicine)

Updates on Tissue Repair and Regeneration Pathways

edited by

Cornel Baltă

and

Oana-Maria Boldura

submission deadline 31 Oct 2025 | Viewed by 340 | Submission Open

Keywords: tissue repair; tissue regeneration; molecular pathways involved in repair and regeneration; extracellular matrix; drug delivery systems

(This special issue belongs to the Section Biomedical Engineering and Materials)

Post Tuberculosis Lung Disease from Lung Damage to the Loss of Lung Function

edited by

Oana Cristina Arghir

and Ariadna Petronela Fildan

submission deadline 31 Oct 2025 | Viewed by 325 | Submission Open

Keywords: post-tuberculosis lung disease (PTLD); post-TB conditions; TB sequelae; obstructive post-TB disease; post-TB syndromes

(This special issue belongs to the Section Molecular and Translational Medicine)

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