Selected Papers in the 2nd International Electronic Conference on Biomedicines (ECB 2023)

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (1 March 2024) | Viewed by 5957

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Auckland Bioengineering Institute, University of Auckland, Auckland 1142, New Zealand
Interests: diabetes; obesity; cancer; non-communicalbe diseases; marine natural compounds; fucoidan; seaweed; clams; food chemistry; pharmacology; drug metabolism; pharmacokinetics; pre-clinical pharmacology; natural compound extraction; polyamine metabolism; marine bioactives
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Laboratory for Medical Mass Spectrometry, Biomedicine group, Alborg University, Aalborg, Denmark
Interests: proteomics; post-translational modifications; personalized medicine; liquid biomarkers
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Neuroscience Research Group, Hungarian Academy of Sciences, University of Szeged (MTA-SZTE), 6720 Szeged, Hungary
Interests: neurohormones; neuropeptides; tryptophan; kynurenine; psychiatry; neurology; depression; anxiety; dementia; cognition; antidepressant; translational research
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Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
Interests: cancer cell biology; microRNAs; pediatric brain tumors; metabolic diseases
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Department of Chemistry and Biomolecular Sciences, John L. Holmes Mass Spectrometry Facility, Faculty of Science, University of Ottawa, Ottawa, ON K1N6N5, Canada
Interests: extracellular vesicles; breast cancer; mass spectrometry; proteomics; phosphoproteomics; metabolomics; bioinformatics; biomarker
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Research Unit of Histology and Embryology, Department of Biology, University of Florence, Florence, Italy
Interests: photobiology; photoimmunology; phototherapy; targeted therapies; photobiomodulation; wound healing; basic sciences
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Imagery Unit, Department of Platforms and Technology Research, French Armed Forces Biomedical Research Institute, 91223 Brétigny-sur-Orge, France
Interests: in situ macrophage characterization; in situ hybridization; cytokine expression
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Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
Interests: Burkholderia cepacia complex; antimicrobials; bacterial virulence; immunoproteomics; immunotherapeutic strategies
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1. Retired, The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, 1 Discovery Drive (Room 238), Rensselaer, NY 12144, USA
2. Vascular Vision Pharmaceuticals Co., Rensselaer Polytechnic Park, Troy, NY 12180, USA
Interests: pharmaceuticals; biopharmaceuticals and diagnostics; nanomedicine; cardiovascular diseases; neurological disorders; hematology and oncology; biosimilar and nanosimilar; angiogenesis; inflammation; thrombosis; integrin and cell adhesion molecules; target identification; molecular mechanisms and signaling pathways; preclinical; clinical; marketing and post marketing studies; regulatory and ethical issues
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Department of Gastroenterological Endoscopy, Tokyo Medical University, Tokyo, Japan
Interests: gastric cancer; intestinal metaplasia; gastritis; tumor immunity; helicobacter pylori; gastric microbiota; endoscopy; cancer surveillance; cancer chemoprevention; colorectal cancer; artificial intelligence
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Department of Clinical Sciences, Division of Dermatology and Venereology, Lund University, Lund, Sweden
Interests: peptide; inflammatory; aggregation; apolipoprotiens; innate immunity; host defense peptides
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Special Issue Information

Dear Colleagues,

ECB 2023 will present the latest research related to all aspects of research on human health and diseases; the discovery and characterization of new therapeutic targets and therapeutic strategies; and research of naturally driven biomedicines, pharmaceuticals, and biopharmaceutical products. Topics of interest include, but are not limited to:

ECB 2023 is an electronic conference sponsored by Biomedicines. Participation is free of charge for authors and attendees. Accepted papers will be gathered in the proceedings of the conference. Selected extended versions of the papers will be published in a Special Issue of Biomedicines and undergo full peer review (ISSN 2227-9059; impact factor: 4.757 (2022)) with a 20% discount on the article processing charge. ECB 2023 offers you the opportunity to participate in this international, scholarly conference without the concerns or expenditure of travel—all you need is your computer and access to the internet. We would like to invite you to attend this conference and present your latest work.

Prof. Dr. Jun Lu
Dr. Allan Stensballe
Dr. Masaru Tanaka
Dr. Giuseppina Catanzaro
Dr. Zoran Minic
Dr. Stefano Bacci
Dr. Krisztina Nikovics
Dr. Sílvia A. Sousa
Prof. Dr. Ciro Isidoro
Prof. Dr. Shaker A. Mousa
Dr. Ryota Niikura
Dr. Jitka Petrlova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

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13 pages, 1946 KiB  
Article
Different Trajectories for Diabetes Mellitus Onset and Recovery According to the Centralized Aerobic–Anaerobic Energy Balance Compensation Theory
by Alexandre A. Vetcher, Kirill V. Zhukov, Bagrat A. Gasparyan, Pavel I. Borovikov, Arfenia S. Karamian, Dovlet T. Rejepov, Maria N. Kuznetsova and Alexander Y. Shishonin
Biomedicines 2023, 11(8), 2147; https://doi.org/10.3390/biomedicines11082147 - 30 Jul 2023
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Abstract
We recently reported that the restoration of cervical vertebral arterial blood flow access (measured as systolic peak (PS)) to the rhomboid fossa leads to the recovery of the HbA1c level in the case of patients with a pre-Diabetes Mellitus (pre-DM) condition. The theory [...] Read more.
We recently reported that the restoration of cervical vertebral arterial blood flow access (measured as systolic peak (PS)) to the rhomboid fossa leads to the recovery of the HbA1c level in the case of patients with a pre-Diabetes Mellitus (pre-DM) condition. The theory of centralized aerobic–anaerobic energy balance compensation (TCAAEBC) provides a successful theoretical explanation for this observation. It considers the human body as a dissipative structure. Reported connections between arterial hypertension (AHT) and the level of HbA1c are linked through OABFRH. According to the TCAAEBC, this delivers incorrect information about blood oxygen availability to the cerebellum. The restoration of PS normalizes AHT in 5–6 weeks and HbA1c in 12–13 weeks. In the current study, we demonstrate the model which fits the obtained experimental data. According to the model, pathways of onset and recovery from pre-DM are different. The consequence of these differences is discussed. The great significance of the TCAAEBC for medical practice forces the creation of an appropriate mathematical model, but the required adjustment of the model needs experimental data which can only be obtained from an animal model(s). The essential part of this study is devoted to the analysis of the advantages and disadvantages of widely available common mammalian models for TCAAEBC cases. Full article
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16 pages, 2310 KiB  
Article
Cancer Is Associated with the Emergence of Placenta-Reactive Autoantibodies
by Sara Khorami Sarvestani, Sorour Shojaeian, Ramin Sarrami-Forooshani, Mir Saeed Yekaninejad, Kambiz Gilany, Abbas Ghaderi, Maryam Hashemnejad, Asiie Olfatbakhsh, Farzane Notash Haghighat, Samaneh Montazeri, Allan Stensballe, Mahmood Jeddi-Tehrani and Amir-Hassan Zarnani
Biomedicines 2023, 11(2), 316; https://doi.org/10.3390/biomedicines11020316 - 23 Jan 2023
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Abstract
Placenta-specific antigens are minimally expressed or unexpressed in normal adult tissues, while they are widely expressed in cancer. In the course of carcinogenesis, a vast array of autoantibodies (AAbs) is produced. Here, we used a quantitative approach to determine the reactivity of AAbs [...] Read more.
Placenta-specific antigens are minimally expressed or unexpressed in normal adult tissues, while they are widely expressed in cancer. In the course of carcinogenesis, a vast array of autoantibodies (AAbs) is produced. Here, we used a quantitative approach to determine the reactivity of AAbs in the sera of patients with breast (BrC: N = 100, 100% female, median age: 51 years), gastric (GC: N = 30, 46.6% female, median age: 57 years), bladder (BC: N = 29, 34.4% female, median age: 57 years), and colorectal (CRC: N = 34, 41.1% female, median age: 51 years) cancers against first-trimester (FTP) and full-term placental proteome (TP) in comparison with age- and sex-matched non-cancer individuals. Human-on-human immunohistochemistry was used to determine reactive target cells in FTP. The effect of pregnancy on the emergence of placenta-reactive autoantibodies was tested using sera from pregnant women at different trimesters of pregnancy. Except for BC, patients with BrC (p < 0.0284), GC (p < 0.0002), and CRC (p < 0.0007) had significantly higher levels of placenta-reactive AAbs. BrC (p < 0.0001) and BC (p < 0.0409) in the early stages triggered higher autoantibody reactivity against FTP. The reactivities of BrC sera with FTP did not show an association with ER, PR, or HER2 expression. Pregnancy in the third trimester was associated with the induction of TP- and not FTP-reactive autoantibodies (=0.018). The reactivity of BrC sera with placental proteins was found to be independent of gravidity or abortion. BrC sera showed a very strong and specific pattern of reactivity with scattered cells beneath the syncytiotrophoblast layer. Our results reinforce the concept of the coevolution of placentation and cancer and shed light on the future clinical application of the placental proteome for the non-invasive early detection and treatment of cancer. Full article
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Review

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16 pages, 17040 KiB  
Review
The Emergence of TRP Channels Interactome as a Potential Therapeutic Target in Pancreatic Ductal Adenocarcinoma
by Yuanyuan Wei, Ahmad Taha Khalaf, Cao Rui, Samiah Yasmin Abdul Kadir, Jamaludin Zainol and Zahraa Oglah
Biomedicines 2023, 11(4), 1164; https://doi.org/10.3390/biomedicines11041164 - 13 Apr 2023
Cited by 2 | Viewed by 1831
Abstract
Integral membrane proteins, known as Transient Receptor Potential (TRP) channels, are cellular sensors for various physical and chemical stimuli in the nervous system, respiratory airways, colon, pancreas, bladder, skin, cardiovascular system, and eyes. TRP channels with nine subfamilies are classified by sequence similarity, [...] Read more.
Integral membrane proteins, known as Transient Receptor Potential (TRP) channels, are cellular sensors for various physical and chemical stimuli in the nervous system, respiratory airways, colon, pancreas, bladder, skin, cardiovascular system, and eyes. TRP channels with nine subfamilies are classified by sequence similarity, resulting in this superfamily’s tremendous physiological functional diversity. Pancreatic Ductal Adenocarcinoma (PDAC) is the most common and aggressive form of pancreatic cancer. Moreover, the development of effective treatment methods for pancreatic cancer has been hindered by the lack of understanding of the pathogenesis, partly due to the difficulty in studying human tissue samples. However, scientific research on this topic has witnessed steady development in the past few years in understanding the molecular mechanisms that underlie TRP channel disturbance. This brief review summarizes current knowledge of the molecular role of TRP channels in the development and progression of pancreatic ductal carcinoma to identify potential therapeutic interventions. Full article
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