Special Issue "Selected Papers in the 2nd International Electronic Conference on Biomedicines (ECB 2023)"

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 June 2023 | Viewed by 1140

Special Issue Editors

Auckland Bioengineering Institute, University of Auckland, Auckland 1142, New Zealand
Interests: diabetes; obesity; cancer; non-communicalbe diseases; marine natural compounds; fucoidan; seaweed; clams; food chemistry; pharmacology; drug metabolism; pharmacokinetics; pre-clinical pharmacology; natural compound extraction; polyamine metabolism; marine bioactives
Special Issues, Collections and Topics in MDPI journals
Laboratory for Medical Mass Spectrometry, Biomedicine group, Alborg University, Aalborg, Denmark
Interests: proteomics; post-translational modifications; personalized medicine; liquid biomarkers
Special Issues, Collections and Topics in MDPI journals
Neuroscience Research Group, Hungarian Academy of Sciences-University of Szeged (MTA-SZTE), 6720 Szeged, Hungary
Interests: neurohormones; neuropeptides; tryptophan; kynurenine; psychiatry; neurology; depression; anxiety; dementia; cognition; antidepressant; translational research
Special Issues, Collections and Topics in MDPI journals
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
Interests: cancer cell biology; microRNAs; pediatric brain tumors; metabolic diseases
Special Issues, Collections and Topics in MDPI journals
Department of Chemistry and Biomolecular Sciences, John L. Holmes Mass Spectrometry Facility, Faculty of Science, University of Ottawa, Ottawa, ON K1N6N5, Canada
Interests: extracellular vesicles; breast cancer; mass spectrometry; proteomics; phosphoproteomics; metabolomics; bioinformatics; biomarker
Special Issues, Collections and Topics in MDPI journals
Research Unit of Histology and Embryology, Department of Biology, University of Florence, Florence, Italy
Interests: photobiology; photoimmunology; phototherapy; targeted therapies; photobiomodulation; wound healing; basic sciences
Special Issues, Collections and Topics in MDPI journals
Imagery Unit, Department of Platforms and Technology Research, French Armed Forces Biomedical Research Institute, 91223 Brétigny-sur-Orge, France
Interests: in situ macrophage characterization; in situ hybridization; cytokine expression
Special Issues, Collections and Topics in MDPI journals
Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
Interests: Burkholderia cepacia complex; antimicrobials; bacterial virulence; immunoproteomics; immunotherapeutic strategies
Special Issues, Collections and Topics in MDPI journals
The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, 1 Discovery Drive (Room 238), Rensselaer, NY 12144, USA
Interests: pharmaceuticals; biopharmaceuticals and diagnostics; nanomedicine; cardiovascular diseases; neurological disorders; hematology and oncology; biosimilar and nanosimilar; angiogenesis, inflammation; thrombosis; integrin and cell adhesion molecules; target identification; molecular mechanisms and signaling pathways; preclinical; clinical; marketing and post marketing studies; regulatory and ethical issues
Special Issues, Collections and Topics in MDPI journals
Department of Gastroenterological Endoscopy, Tokyo Medical University, Tokyo, Japan
Interests: gastric cancer; intestinal metaplasia; gastritis; tumor immunity; helicobacter pylori; gastric microbiota; endoscopy; cancer surveillance; cancer chemoprevention; colorectal cancer; artificial intelligence
Special Issues, Collections and Topics in MDPI journals
Department of Clinical Sciences, Division of Dermatology and Venereology, Lund University, Lund, Sweden
Interests: peptide; inflammatory; aggregation; apolipoprotiens; innate immunity; host defense peptides
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

ECB 2023 will present the latest research related to all aspects of research on human health and diseases; the discovery and characterization of new therapeutic targets and therapeutic strategies; and research of naturally driven biomedicines, pharmaceuticals, and biopharmaceutical products. Topics of interest include, but are not limited to:

ECB 2023 is an electronic conference sponsored by Biomedicines. Participation is free of charge for authors and attendees. Accepted papers will be gathered in the proceedings of the conference. Selected extended versions of the papers will be published in a Special Issue of Biomedicines and undergo full peer review (ISSN 2227-9059; impact factor: 4.757 (2022)) with a 20% discount on the article processing charge. ECB 2023 offers you the opportunity to participate in this international, scholarly conference without the concerns or expenditure of travel—all you need is your computer and access to the internet. We would like to invite you to attend this conference and present your latest work.

Prof. Dr. Jun Lu
Dr. Allan Stensballe
Dr. Masaru Tanaka
Dr. Giuseppina Catanzaro
Dr. Zoran Minic
Dr. Stefano Bacci
Dr. Krisztina Nikovics
Dr. Sílvia A. Sousa
Prof. Dr. Ciro Isidoro
Prof. Dr. Shaker A. Mousa
Dr. Ryota Niikura
Dr. Jitka Petrlova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Article
Cancer Is Associated with the Emergence of Placenta-Reactive Autoantibodies
Biomedicines 2023, 11(2), 316; https://doi.org/10.3390/biomedicines11020316 - 23 Jan 2023
Viewed by 748
Abstract
Placenta-specific antigens are minimally expressed or unexpressed in normal adult tissues, while they are widely expressed in cancer. In the course of carcinogenesis, a vast array of autoantibodies (AAbs) is produced. Here, we used a quantitative approach to determine the reactivity of AAbs [...] Read more.
Placenta-specific antigens are minimally expressed or unexpressed in normal adult tissues, while they are widely expressed in cancer. In the course of carcinogenesis, a vast array of autoantibodies (AAbs) is produced. Here, we used a quantitative approach to determine the reactivity of AAbs in the sera of patients with breast (BrC: N = 100, 100% female, median age: 51 years), gastric (GC: N = 30, 46.6% female, median age: 57 years), bladder (BC: N = 29, 34.4% female, median age: 57 years), and colorectal (CRC: N = 34, 41.1% female, median age: 51 years) cancers against first-trimester (FTP) and full-term placental proteome (TP) in comparison with age- and sex-matched non-cancer individuals. Human-on-human immunohistochemistry was used to determine reactive target cells in FTP. The effect of pregnancy on the emergence of placenta-reactive autoantibodies was tested using sera from pregnant women at different trimesters of pregnancy. Except for BC, patients with BrC (p < 0.0284), GC (p < 0.0002), and CRC (p < 0.0007) had significantly higher levels of placenta-reactive AAbs. BrC (p < 0.0001) and BC (p < 0.0409) in the early stages triggered higher autoantibody reactivity against FTP. The reactivities of BrC sera with FTP did not show an association with ER, PR, or HER2 expression. Pregnancy in the third trimester was associated with the induction of TP- and not FTP-reactive autoantibodies (=0.018). The reactivity of BrC sera with placental proteins was found to be independent of gravidity or abortion. BrC sera showed a very strong and specific pattern of reactivity with scattered cells beneath the syncytiotrophoblast layer. Our results reinforce the concept of the coevolution of placentation and cancer and shed light on the future clinical application of the placental proteome for the non-invasive early detection and treatment of cancer. Full article
Show Figures

Figure 1

Back to TopTop