Pioneering the Path to Pain Management: Discovering Unexplored Analgesic Targets in Anesthesia Research

A special issue of Anesthesia Research (ISSN 2813-5806).

Deadline for manuscript submissions: 31 July 2024 | Viewed by 702

Special Issue Editor

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Guest Editor
HUN-REN-SZTE Neuroscience Research Group, Hungarian Research Network, University of Szeged (HUN-REN-SZTE), Szeged, Hungary
Interests: neurohormones; neuropeptides; tryptophan; kynurenine; psychiatry; neurology; depression; anxiety; dementia; pain; Alzheimer’s disease; cognition; antidepressant; translational research
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Special Issue Information

Dear Colleagues,

We are pleased to announce a Special Issue on 'Pioneering the Path to Pain Management: Discovering Unexplored Analgesic Targets in Anesthesia Research,' which aims to explore new avenues for pain relief in anesthesia practice. Pain management is a critical aspect of anesthesia practice, and there is a need for new analgesic targets that can improve patient outcomes and quality of life. This Special Issue aims to showcase cutting-edge research in this area and highlight the potential of unexplored analgesic targets. We invite original research papers, review articles, and case reports that focus on discovering new analgesic targets in anesthesia practice. Topics of interest include, but are not limited to, the mechanisms of action of new analgesics, their efficacy and safety, and their potential applications in different patient populations. This Special Issue will provide a platform for researchers to share their latest findings and contribute to the advancement of pain management in anesthesia practice. The published papers will have the potential to inform clinical practice, improve patient care, and inspire further research in this important area. This Special Issue highlights the most recent advances in experimental, clinical, and translational research in the fields of anesthesia research, focusing on novel targets for pain management. We welcome submissions from researchers and practitioners in the field of anesthesia research and look forward to receiving your papers focusing on (but not limited to) the following:

  • Etiology, pathogenesis, and progression mechanisms;
  • Early diagnosis including biomarkers, bio-imaging, and biosensors;
  • Prophylactic, disease-modifying and therapeutic strategies, novel targets;
  • Novel drug discovery and development, naturally driven biomedicines, natural bioactive molecules, and vaccines;
  • Preclinical in vitro models and animal models;
  • Bench-to-bedside translational research;
  • Bedside-to-bench translational research.

Thank you for your interest in this important Special Issue.

Dr. Masaru Tanaka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Anesthesia Research is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • acute postoperative pain
  • multimodal analgesia
  • opioid-sparing techniques
  • procedure-specific pain management
  • pain generators
  • non-pharmacologic therapy
  • regional anesthetic techniques
  • non-opioid pharmacotherapy
  • novel opioids
  • personalized pain management

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Exploring the Potential of Anthranilic Acid and Its Derivatives in Pain Management
Authors: Masaru Tanaka and etc.
Abstract: The kynurenine pathway of tryptophan metabolism is a complex biochemical process that results in the production of several metabolites with diverse biological functions, including pain modulation. Among these metabolites, anthranilic acid has been suggested to exert analgesic effects by interacting with opioid receptors and inhibiting prostaglandin synthesis. However, the levels and roles of anthranilic acid in pain perception and management may vary depending on genetic, ethnic, sex, and nutritional factors. This narrative review presents the current understanding of the potential of anthranilic acid and its related compounds as novel analgesic targets in anesthesia research. First, it discusses the current evidence and mechanisms of action of anthranilic acid as a pain modulator. Second, it reports the differences in kynurenine metabolism and anthranilic acid levels among different groups of healthy volunteers, as well as the effects of tryptophan loading and depletion on these parameters. Third, it discusses the influence of pyridoxal 5′-phosphate, the active form of vitamin B6, on the regulation of kynurenine metabolism and anthranilic acid production. Finally, it provides new insights and perspectives on the role of the kynurenine pathway in pain physiology and pharmacology and paves the way for future studies on the development of novel analgesic strategies based on kynurenine metabolites and their derivatives.
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