Special Issue "Epigenetic and Metabolic Alterations in the Tumor Microenvironment"

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".

Deadline for manuscript submissions: 10 October 2021.

Special Issue Editors

Prof. Dr. Ciro Isidoro
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Guest Editor
Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale “A. Avogadro”, Via Solaroli 17, 28100, Novara, Italy
Interests: autophagy; cell death; cathepsins; proteolysis; cancer; neurodegeneration; nutraceuticals; epigenetics
Special Issues and Collections in MDPI journals
Prof. Dr. Danny N. Dhanasekaran

Guest Editor
Stephenson Cancer Center, Oklahoma University Health Science Center Oklahoma City, OK 73104, USA
Interests: cancer; cell signaling; non-coding RNA; tumor microenvironment
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer is an organoid in which parenchymal cancer cells are embedded together with several other cell types in a complex matrix in which the presence of nutrients, oxygen, and signaling molecules (cytokines, growth factors) is subjected to dynamic changes. The intercellular communications between malignant cancer cells and cancer-associated fibroblasts and immune cells present in the stroma lead to continuous remodeling of the tumor microenvironment, which then impinges on the progression of cancer. In this scenario, epigenetic changes caused by microenvironmental factors play a major role in metabolic reprogramming and, consequently, in the behavior of cancer cells.

In this Special Issue, we wish to collect original research and review articles addressing the epigenetic and metabolic alterations occurring in the tumor environment that influence cancer progression through impacting the proliferation, migration and invasion, dormancy, stemness, and resistance to therapy of cancer cells.

Prof. Dr. Ciro Isidoro
Prof. Dr. Danny N. Dhanasekaran
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • tumor microenvironment
  • hypoxia
  • inflammation
  • cytokines
  • epigenetics
  • metabolic cross-talk
  • cancer stroma cells
  • epigenetic alterations
  • cancer cell dormancy
  • cancer cell proliferation
  • cancer cell migration
  • cancer cell stemness

Published Papers (1 paper)

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Open AccessReview
MicroRNA-Mediated Metabolic Shaping of the Tumor Microenvironment
Cancers 2021, 13(1), 127; https://doi.org/10.3390/cancers13010127 - 03 Jan 2021
Cited by 1 | Viewed by 690
The metabolism of cancer cells is generally very different from what is found in normal counterparts. However, in a tumor mass, the continuous crosstalk and competition for nutrients and oxygen among different cells lead to metabolic alterations, not only in cancer cells, but [...] Read more.
The metabolism of cancer cells is generally very different from what is found in normal counterparts. However, in a tumor mass, the continuous crosstalk and competition for nutrients and oxygen among different cells lead to metabolic alterations, not only in cancer cells, but also in the different stromal and immune cells of the tumor microenvironment (TME), which are highly relevant for tumor progression. MicroRNAs (miRs) are small non-coding RNAs that silence their mRNA targets post-transcriptionally and are involved in numerous physiological cell functions as well as in the adaptation to stress situations. Importantly, miRs can also be released via extracellular vesicles (EVs) and, consequently, take part in the bidirectional communication between tumor and surrounding cells under stress conditions. Certain miRs are abundantly expressed in stromal and immune cells where they can regulate various metabolic pathways by directly suppressing enzymes or transporters as well as by controlling important regulators (such as transcription factors) of metabolic processes. In this review, we discuss how miRs can induce metabolic reprogramming in stromal (fibroblasts and adipocytes) and immune (macrophages and T cells) cells and, in turn, how the biology of the different cells present in the TME is able to change. Finally, we debate the rebound of miR-dependent metabolic alterations on tumor progression and their implications for cancer management. Full article
(This article belongs to the Special Issue Epigenetic and Metabolic Alterations in the Tumor Microenvironment)
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