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Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Function of Steroid Receptors and Their Epigenetic Co-Regulators in Tissue Homeostasis

edited by Delphine Duteil and

Qingshuang Cai

submission deadline 31 Mar 2027 | Viewed by 199 | Submission Open

Keywords: steroid receptors; epigenetic co-regulators; chromatin remodeling; transcriptional regulation; tissue homeostasis; hormone signaling; nuclear receptors; epigenomics

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Targeting Sphingolipids for Cancer Therapy

edited by

Christopher D. Green

submission deadline 31 Mar 2027 | Viewed by 197 | Submission Open

Keywords: sphingolipids; lipid; cancer; therapeutics; sphingosine-1-phosphate; ceramide; tumor microenvironment; metastasis; tumor growth

(This special issue belongs to the Section Cancer Biology)

Cell Biology and Ultrastructure of Parasites

edited by Marcos Andre Vannier-Santos

submission deadline 31 Mar 2027 | Viewed by 142 | Submission Open

Keywords: parasite cell biology; functional ultrastructure; subcellular organization; pathogen biology; host cell infection; parasitism molecular/cellular strategies

(This special issue belongs to the Section Infection Biology)

Functional Soil Biodiversity: Microbial Ecology, Environmental Stress, and Ecosystem Resilience

edited by Kalisa Bogati and Maciej Walczak

submission deadline 31 Mar 2027 | Viewed by 59 | Submission Open

Keywords: soil biodiversity; soil microbiome; microbial ecology; soil health; ecosystem resilience; environmental biotechnology; bioremediation; sustainable agriculture

Forest Tree Functional Genomics: From Gene Networks to Physiological Regulation

edited by

Jun Ni

submission deadline 1 Apr 2027 | 1 articles | Viewed by 730 | Submission Open

Keywords: anthocyanin; secondary metabolism; abiotic and biotic stresses; shoot branching; transcriptome; metabolome; transformation

(This special issue belongs to the Section Plant Science)

Maternal Adaptation in Physiological and Pathological Pregnancy (2nd Edition)

edited by

Qi Chen

and

Yunhui Tang

submission deadline 15 Apr 2027 | 1 articles | Viewed by 1026 | Submission Open

Keywords: pregnancy; maternal adaptation; placenta; cardiovascular system; immune system; complications of preg-nancy; early prediction

(This special issue belongs to the Section Developmental and Reproductive Biology)

Advancing Translational Science Using Bioinformatics and Big Data-Driven Approaches

edited by

Zongliang Yue

submission deadline 30 Apr 2027 | 8 articles | Viewed by 13257 | Submission Open

Keywords: bioinformatics; big data analytics; artificial intelligence (AI); machine learning; deep learning; translational science; computational biology; drug repositioning; biomarker discovery; genomics; medical imaging; digital pathology; integrative analysis; disease mechanisms; functional genomics analysis; computational tool application; ethical and safety considerations; data-driven approaches

(This special issue belongs to the Section Bioinformatics)

Machine Learning Applications in Biology—2nd Edition

edited by

Georgios K. Georgakilas

submission deadline 30 Apr 2027 | 5 articles | Viewed by 12010 | Submission Open

Keywords: machine learning; genomics; epigenomics; genetic variation and the environment; gene regulatory networks; integration of multipurpose NGS data

(This special issue belongs to the Section Bioinformatics)

Epigenetic and Genetic Control of Sperm Development and Function: From Fertility to Inheritance

edited by

Candela Rocío González

submission deadline 30 Apr 2027 | 3 articles | Viewed by 10881 | Submission Open

Keywords: spermatogenesis; epigenetics; sperm; male fertility; DNA methylation; histone modifications; small RNAs; epigenetic inheritance

(This special issue belongs to the Section Genetics and Genomics)

Recent Advances in Animal Anatomy

edited by

Korakot Nganvongpanit

submission deadline 30 Apr 2027 | 2 articles | Viewed by 4654 | Submission Open

Keywords: animal anatomy; comparative morphology; imaging anatomy; molecular anatomy; veterinary anatomy; functional morphology; evolutionary biology; wildlife conservation; developmental anatomy; anatomical adaptations

(This special issue belongs to the Section Zoology)

Germplasm Resources and Molecular Breeding for Sustainable Aquatic Species Improvement

edited by

Falin Zhou

submission deadline 30 Apr 2027 | 5 articles | Viewed by 4351 | Submission Open

Keywords: germplasm resource evaluation; molecular marker; genomics; gene editing; selective breeding; environment adaptation

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Neurogenetics of Behaviour—2nd Edition

edited by

Charalambos Kyriacou

submission deadline 30 Apr 2027 | 2 articles | Viewed by 4055 | Submission Open

Keywords: behaviour; genetics; molecules; species; brain; networks; health; disease

(This special issue belongs to the Section Genetics and Genomics)

Research Progress in Microbial Genetics and Genomics

edited by

Rapee Thummeepak

and Udomluk Leungtongkam

submission deadline 30 Apr 2027 | 5 articles | Viewed by 3322 | Submission Open

Keywords: antimicrobial resistance (AMR); microbial genetics and genomics; high-throughput DNA sequencing; comparative genomics and pan-genome; metagenomics and microbiome; mobilome, resistome and virulome; medical microbiology; environmental and food microbiology; probiotic genomics; bacteriology, mycology and virology

(This special issue belongs to the Section Microbiology)

The Molecular Mechanisms of Chronic Inflammation Occurrence and Development

edited by Meixiu Jiang

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2595 | Submission Open

Keywords: atherosclerosis; vascular calcification; neointima; macrophage; inflammation; phenotypic transformation of smooth muscle cell; endothelial dysfunction

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Population Genomics in Biodiversity Conservation in the Neotropics

edited by Rubens Pasa, Caroline Garcia and

Karine Frehner Kavalco

submission deadline 30 Apr 2027 | 1 articles | Viewed by 2179 | Submission Open

Keywords: biodiversity; genomics; conservation; bioinformatics; population genomics

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Neuropeptide Signaling at the Interface of Immunity and Metabolism

edited by

Glenn P. Dorsam

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1687 | Submission Open

Keywords: VIP; PACAP; metabolism; immunoregulation; gluconeogenesis

(This special issue belongs to the Section Medical Biology)

AI Deep Learning Approach to Study Biological Questions (3rd Edition)

edited by

Chung-Der Hsiao

and

Che-Chia Tsao

submission deadline 30 Apr 2027 | 2 articles | Viewed by 1038 | Submission Open

Keywords: OpenCV; Mask RCNN; YOLO; U-Net; StarDist; ImageJ; MATLAB; image segmentation; image classification; locomotion trajectory analysis; volumetric prediction; plants; animals; protozoa; invertebrates; animal behavior; developmental biology toxicology; zebrafish; medaka; daphnia

(This special issue belongs to the Section Bioinformatics)

Microbial Communities: Interactions, Evolution, and Function

edited by Krisztina Nagy, Peter Galajda and Juan E. Keymer

submission deadline 30 Apr 2027 | 1 articles | Viewed by 797 | Submission Open

Keywords: microbial communities; microbial interactions; microbial communication; spatial organization; biofilm formation; evolution

(This special issue belongs to the Section Ecology)

Animal Models for Disease Mechanisms (2nd Edition)

edited by

Isabel R. Dias

submission deadline 30 Apr 2027 | Viewed by 523 | Submission Open

Keywords: animal models; spontaneous models; induced models; disease mechanisms; pathogenesis research

(This special issue belongs to the Section Zoology)

Advances in Cell Division and Chromosome Segregation Mechanisms

edited by

Zhixin (Jason) Lyu

submission deadline 30 Apr 2027 | Viewed by 508 | Submission Open

Keywords: cell division; chromosome segregation; bacterial cell biology; mammalian cell cycle; genome stability; cytoskeletal dynamics; structural biology; advanced imaging

(This special issue belongs to the Section Cell Biology)

Advances in Embryo Biotechnology and Stem Cell Applications for Animal Conservation and Production

edited by

Rangsun Parnpai

and Ampika Thongphakdee

submission deadline 30 Apr 2027 | Viewed by 244 | Submission Open

Keywords: gametes; embryos; IVP; iPSCs; IVG; cryopreservation; livestock; endangered species; production; conservation

(This special issue belongs to the Section Developmental and Reproductive Biology)

Underrepresented Pathogens: Evolution, Adaptation, and Biological Mechanisms Across Kingdoms

edited by

Dan-Alexandru Țoc

and Ioana Alina Colosi

submission deadline 30 Apr 2027 | Viewed by 219 | Submission Open

Keywords: underrepresented; emerging pathogens; microbial adaptation; evolution and pathogenicity; genome plasticity; host–pathogen interaction; experimental evolution; ecological transitions

(This special issue belongs to the Section Microbiology)

Investigating Reproductive System Diseases Through Animal Models

edited by Diogo Benchimol de Souza

submission deadline 30 Apr 2027 | Viewed by 183 | Submission Open

Keywords: reproductive diseases; animal models; infertility; spermatogenesis; ovarian function; endocrine regulation; reproductive toxicology; translational research; experimental pathology; molecular mechanisms

(This special issue belongs to the Section Developmental and Reproductive Biology)

Plant Responses to Biostimulants and Abiotic Stress

edited by

Stefano Loppi

and

Riccardo Fedeli

submission deadline 30 Apr 2027 | Viewed by 176 | Submission Open

Keywords: biostimulants; abiotic stress; wood vinegar; biochar; plant stress tolerance; sustainable agriculture; crop resilience

(This special issue belongs to the Section Plant Science)

Ecology, Conservation Physiology and Population Monitoring of Endangered Animals

edited by

Hao Du

Chenhong Li

and

Peilin Cheng

submission deadline 30 Apr 2027 | Viewed by 105 | Submission Open

Keywords: endangered aquatic animals; conservation physiology; population monitoring; environmental stressors; adaptative mechanisms; innovative technologies

(This special issue belongs to the Section Marine and Freshwater Biology)

Biodiversity, Integrative Taxonomy, Molecular Approaches, Systematics, and Biogeography of Fishes

edited by

Felipe Ottoni

and Elisabeth Henschel

submission deadline 30 Apr 2027 | Viewed by 87 | Submission Open

Keywords: DNA-barcoding; environmental DNA; evolution; phylogenetics; ichthyology; species delimitation methods; species description; species distribution

(This special issue belongs to the Section Marine and Freshwater Biology)

Internal Defense System and Evolution of Aquatic Animals

edited by

Alessio Alesci

submission deadline 15 May 2027 | 10 articles | Viewed by 23811 | Submission Open

Keywords: internal defense system; evolution; aquatic animals; immunology; aquatic environment; biodiversity; pollution; ecosystems

(This special issue belongs to the Section Evolutionary Biology)

Genetic and Genomic Insights into Cardiovascular Disease

edited by Silvio Zaina and

Carol C. Shoulders

submission deadline 15 May 2027 | Viewed by 613 | Submission Open

Keywords: coronary and carotid atheroma; lipids; thrombosis; inflammation; vascular calcification; vascular smooth muscle cells; foam cells; endothelium; immune cells; epigenetics; genetic variation; gene expression and proteomics; cell and disease models

(This special issue belongs to the Section Genetics and Genomics)

Environmental and Lifestyle Drivers of Redox Imbalance: Mechanisms, Biomarkers and Therapeutic Opportunities

edited by Natalia Kurhaluk and Halina Tkaczenko

submission deadline 30 May 2027 | Viewed by 215 | Submission Open

Keywords: redox homeostasis and oxidative stress regulation; environmental toxicants and redox imbalance; dietary antioxidants and bioactive food compounds; gut microbiota–redox interactions; physical activity and ROS‑mediated hormesis; mitochondrial dysfunction and redox‑targeted therapies; redox biomarkers for diagnosis and monitoring

(This special issue belongs to the Section Cell Biology)

Aquatic Animal Nutrition and Feed

edited by

Yun Wang

submission deadline 31 May 2027 | 12 articles | Viewed by 26016 | Submission Open

Keywords: aquaculture; aquatic animals; nutrition; aquatic feed; immunity; metabolism

Head and Neck Cancer: Current Advances and Future Perspectives

edited by Ana Jotic

submission deadline 31 May 2027 | 5 articles | Viewed by 6028 | Submission Open

Keywords: head and neck cancer; tumor microenvironment; genetic and epigenetic alterations; oncogenes and tumor suppressor genes; signal transduction pathways; immune evasion; metastasis; drug resistance mechanisms; molecular etiology; cancer biology

(This special issue belongs to the Section Cancer Biology)

Heavy Metal Pollution and Bioremediation: Application and Mechanism

edited by

Guangxu Zhu

, Ruiyu Lin and Rongfei Wei

submission deadline 31 May 2027 | 3 articles | Viewed by 3957 | Submission Open

Keywords: heavy metal pollutants; microbial remediation; phytoremediation; animal remediation; plant–soil–microbe interactions; enhanced remediation; combined remediation; hyperaccumulator plants; microbial-induced calcium carbonate precipitation

(This special issue belongs to the Section Toxicology)

Studies on Insect Genetics and Genomics

edited by Ying Lin

submission deadline 31 May 2027 | 5 articles | Viewed by 3733 | Submission Open

Keywords: novel sequencing technologies; genome-editing methods; sex chromosome origins; horizontal gene transfer; resource insects; eco-friendly insect control technologies; genomics; ecology; molecular biology; insect

(This special issue belongs to the Section Genetics and Genomics)

Recent Advances in Biological Research on Prostate Cancer

edited by Samson Mashele and Pakiso Makhoahle

submission deadline 31 May 2027 | 1 articles | Viewed by 3456 | Submission Open

Keywords: prostate cancer; biological research; molecular mechanisms; biomarkers; precision medicine; therapeutic targets; tumor microenvironment; therapeutic resistance; genomics; quality of life

(This special issue belongs to the Section Cancer Biology)

Physiology and Pathophysiology of Skin (2nd Edition)

edited by Seon-Pil Jin

submission deadline 31 May 2027 | 1 articles | Viewed by 1339 | Submission Open

Keywords: epidermal barrier; melanogenesis; wound healing; skin immunity; sensory perception; dermatitis; psoriasis; atopic dermatitis; autoimmune skin disorders; therapeutic approaches

(This special issue belongs to the Section Physiology)

Understanding and Targeting Biological Mechanisms of Heart Failure (2nd Edition)

edited by

Lei Ye

and

Wuqiang Zhu

submission deadline 31 May 2027 | Viewed by 1227 | Submission Open

Keywords: developmental biology; genetics; stem cells; heart failure; cell therapy

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Pluripotent Stem Cells in Development and Disease

edited by

Qiang Wu

submission deadline 31 May 2027 | 1 articles | Viewed by 1127 | Submission Open

Keywords: pluripotent stem cells (PSCs); early development; regenerative medicine; genetic/epigenetic factors; differentiation; cell fate determination; disease modelling; organoids; genomic editing; single-cell omics

(This special issue belongs to the Section Developmental and Reproductive Biology)

Drosophila melanogaster: Cutting-Edge Applications in Medicine and Pharmacy

edited by

Yiwen Wang

submission deadline 31 May 2027 | 1 articles | Viewed by 643 | Submission Open

Keywords: Drosophila melanogaster; disease model; drug development; therapeutic target; metabolic disease; cancer; neurodegeneration diseases; cardiovascular disease; pathogenesis; pharmacology

(This special issue belongs to the Section Medical Biology)

Exploring the Role of Serotonin in Psychiatric Disorders

edited by

Georgianna Gould

submission deadline 31 May 2027 | Viewed by 617 | Submission Open

Keywords: diet; drug treatments; enzymes; epigenetic; post translational modification; serotonin metabolism; serotonin receptors; serotonin transporters

(This special issue belongs to the Section Neuroscience)

CRISPR-Engineered Mouse Models for Unraveling Rare Diseases

edited by

Manuel A. Sanchez-Martin

submission deadline 31 May 2027 | Viewed by 459 | Submission Open

Keywords: mouse models; CRISPR/Cas9; rare disease modeling; phenotyping; translational research; svatar mice

(This special issue belongs to the Section Medical Biology)

From GWAS to Mechanism: Genetic Insights into Autoimmune Disease Pathophysiology

edited by Mohsen Khosravi-Maharlooei

submission deadline 31 May 2027 | Viewed by 243 | Submission Open

Keywords: GWAS; autoimmune disease; genetic susceptibility; HLA; functional genomics; single-cell sequencing; epigenomics; immune tolerance; antigen presentation; precision medicine

(This special issue belongs to the Section Physiology)

Advances in Nutritional Biochemistry and Physiology

edited by

Lawrence Mabasa

submission deadline 31 May 2027 | Viewed by 203 | Submission Open

Keywords: nutrition; metabolism; bioactive compounds; gut microbiota; oxidative stress; inflammation; nutrient sensing; micronutrients; dietary regulation; metabolic pathways; animal model; cells

(This special issue belongs to the Section Physiology)

Plant Phenology and Climate Change: Patterns, Responses, and Variability

edited by

Zhi Ding

Fengqin Yan

and

Qi Wang

submission deadline 31 May 2027 | 1 articles | Viewed by 183 | Submission Open

Keywords: plant phenology; climate change; remote sensing; big data; extreme climate events; ecosystem services; coastal wetlands; ecologically fragile regions

(This special issue belongs to the Section Plant Science)

Silk, Honey, and Venom Gene Functions: Research and Applications of Non-Drosophila Resource Insects

edited by

Guanwang Shen

submission deadline 31 May 2027 | Viewed by 142 | Submission Open

Keywords: resource insects; Bombyx mori; Vespula vulgaris; gene function; metabolism; artificial rearing; biomedical applications

(This special issue belongs to the Section Zoology)

Bioinformatics Within Precision Oncology

edited by

Jorge Melendez-Zajgla

submission deadline 31 May 2027 | Viewed by 35 | Submission Open

Keywords: bioinformatics; precision oncology; cancer genomics; multi-omics; machine learning; tumor heterogeneity; variant interpretation; cancer biology; systems biology; computational oncology

(This special issue belongs to the Section Cancer Biology)

Plasticity in the Autonomic Nervous System

edited by

Miguel Angel Morales

submission deadline 3 Jun 2027 | 1 articles | Viewed by 2128 | Submission Open

Keywords: autonomic nervous system; synaptic plasticity; neuroplasticity; neurotransmitters; co-transmission; long-term potentiation; sympathetic nervous system; parasympathetic nervous system; heart; dysautonomia; heart failure

(This special issue belongs to the Section Neuroscience)

From Basics to Applications of Gene Regulatory Networks

edited by

Thomas Ulas

submission deadline 15 Jun 2027 | 4 articles | Viewed by 12353 | Submission Open

Keywords: gene regulatory networks; computational methods; modeling and simulation; disease mechanisms; therapeutic targeting; transcriptomics

(This special issue belongs to the Section Genetics and Genomics)

Advances in Infection and Genetic Diversity of Zoonotic Parasites, Hosts and Vectors

edited by

Weerachai Saijuntha

submission deadline 30 Jun 2027 | 3 articles | Viewed by 8032 | Submission Open

Keywords: zoonotic parasites; prevalence of infection; helminths; protozoa; vectors; genetic diversity; zoonoses; hosts

(This special issue belongs to the Section Infection Biology)

Research Advances in Aquatic Omics

edited by

Zhengyong Wen

Qiong Shi

and Haiping Liu

submission deadline 30 Jun 2027 | 6 articles | Viewed by 7171 | Submission Open

Keywords: aquatic animals; genomics; transcriptomics; proteomics; metabolomics; genetics; evolutionary biology

(This special issue belongs to the Section Evolutionary Biology)

Advances in Biological Breast Cancer Research (2nd Edition)

edited by Anna-Mart Engelbrecht,

Joji Mercier

and

Iman Van Den Bout

submission deadline 30 Jun 2027 | 5 articles | Viewed by 6951 | Submission Open

Keywords: breast cancer; breast tumor; breast cancer cells; animal models; cell death; cancer diagnosis; cancer treatment; biomarkers; cancer microenvironment; carcinogens; estrogen receptor; molecular biology; cell biology

(This special issue belongs to the Section Cancer Biology)

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