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Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Studies on Antioxidant Activity of Natural Products from Plants

edited by

Pornsiri Pitchakarn

and

Piya Temviriyanukul

submission deadline 31 May 2026 | Viewed by 281 | Submission Open

Keywords: plant natural products; phytochemicals; antioxidant activity; free radical scavenging; functional foods; oxidative stress-accelerated diseases

(This special issue belongs to the Section Plant Science)

Pluripotent Stem Cells in Development and Disease

edited by

Qiang Wu

submission deadline 31 May 2026 | Viewed by 113 | Submission Open

Keywords: pluripotent stem cells (PSCs); early development; regenerative medicine; genetic/epigenetic factors; differentiation; cell fate determination; disease modelling; organoids; genomic editing; single-cell omics

(This special issue belongs to the Section Developmental and Reproductive Biology)

Machine Learning Advanced Research on Ecosystem Carbon and Nitrogen Cycles

edited by Fenghui Yuan and

Tao Liu

submission deadline 31 May 2026 | Viewed by 92 | Submission Open

Keywords: machine learning; biogeochemical cycles; ecosystem modeling; carbon cycling; nitrogen cycling; greenhouse gas; climate change; land-use change; data assimilation

(This special issue belongs to the Section Ecology)

Coping with Temperature Increase Induced by Climate Warming: Trends in Ectothermic Species—2nd Edition

edited by

Andreas Walzer

submission deadline 31 May 2026 | Viewed by 68 | Submission Open

Keywords: biodiversity; climate warming; ectothermic species; geographic ranges; heat waves; evolutionary adaptations; phenotypic plasticity; species interactions; thermal acclimation

Head and Neck Cancer: Current Advances and Future Perspectives

edited by Ana Jotic

submission deadline 31 May 2026 | Viewed by 67 | Submission Open

Keywords: head and neck cancer; tumor microenvironment; genetic and epigenetic alterations; oncogenes and tumor suppressor genes; signal transduction pathways; immune evasion; metastasis; drug resistance mechanisms; molecular etiology; cancer biology

(This special issue belongs to the Section Cancer Biology)

Studies on Insect Genetics and Genomics

edited by Ying Lin

submission deadline 31 May 2026 | Viewed by 65 | Submission Open

Keywords: novel sequencing technologies; genome-editing methods; sex chromosome origins; horizontal gene transfer; resource insects; eco-friendly insect control technologies; genomics; ecology; molecular biology; insect

(This special issue belongs to the Section Genetics and Genomics)

Animal Models for Immune and Infectious Diseases

edited by Shijun Zheng

submission deadline 31 May 2026 | Viewed by 39 | Submission Open

Keywords: animal models; immune responses; autoimmunity; infectious diseases; host– pathogen interaction; immunotherapies

Wetland Ecosystems (2nd Edition)

edited by

Jian Li

, Chenglang Pan and Qiang Wang

submission deadline 1 Jun 2026 | 13 articles | Viewed by 23015 | Submission Open

Keywords: biological invasion; pollution; carbon sink function; the biogeochemical cycle of biogenic elements; population and community ecology; global climate change; coastal zone management; the structure and function of the microbiome; environmental adaptation mechanisms of wetland organisms; wetland landscape; wetland degradation

(This special issue belongs to the Section Ecology)

Animal Models of Neurodegenerative Diseases

edited by Xiangyu Guo

submission deadline 1 Jun 2026 | 6 articles | Viewed by 11628 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer's disease; amyotrophic lateral sclerosis; Parkinson's disease; Huntington's disease; neuroscience; animal models; pathogenesis

(This special issue belongs to the Section Neuroscience)

Biomarkers in Stress Biology and Ecology

edited by

and

submission deadline 1 Jun 2026 | 3 articles | Viewed by 8399 | Submission Open

Keywords: biomarkers; ecotoxicology; environmental contamination; stress ecology; neurotoxicity; oxidative stress; pollution

Interactions and Cross-Kingdom Regulation of Hosts and Pathogens/Parasites

edited by

Rui Guo

and Jianfeng Qiu

submission deadline 1 Jun 2026 | Viewed by 86 | Submission Open

Keywords: host; pathogen; parasite; interaction; cross-kingdom regulation; immune response; infection

(This special issue belongs to the Section Microbiology)

Recent Advances in Biosynthesis and Degradation of Plant Anthocyanin

edited by

Qinsong Yang

and

Minjie Qian

submission deadline 15 Jun 2026 | 7 articles | Viewed by 14371 | Submission Open

Keywords: anthocyanin; fruit ripening; flowering coloration; leaf coloration; secondary metabolite; molecular mechanism

(This special issue belongs to the Section Plant Science)

From Basics to Applications of Gene Regulatory Networks

edited by

Thomas Ulas

submission deadline 15 Jun 2026 | 3 articles | Viewed by 5234 | Submission Open

Keywords: gene regulatory networks; computational methods; modeling and simulation; disease mechanisms; therapeutic targeting; transcriptomics

(This special issue belongs to the Section Genetics and Genomics)

Pregnancy Health and Complications: Molecular Processes and Mechanisms

edited by

Shibin Cheng

submission deadline 30 Jun 2026 | 6 articles | Viewed by 28189 | Submission Open

Keywords: placenta; uterine; fetus; adverse pregnancy outcome; preterm birth; preeclampsia; gestational diabetes; maternal– fetal interface; immune tolerance; inflammation

(This special issue belongs to the Section Developmental and Reproductive Biology)

New Insights into Skeletal Muscle Metabolism in Pathological and Physiological Conditions

edited by

Cristina Antinozzi

submission deadline 30 Jun 2026 | 9 articles | Viewed by 7245 | Submission Open

Keywords: skeletal muscle; muscle diseases; hormones; physical exercise; muscle physiology; biomarkers; disease prevention; antibodies; pharmacological approaches; cell metabolism

(This special issue belongs to the Section Cell Biology)

Advances in Infection and Genetic Diversity of Zoonotic Parasites, Hosts and Vectors

edited by

Weerachai Saijuntha

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1331 | Submission Open

Keywords: zoonotic parasites; prevalence of infection; helminths; protozoa; vectors; genetic diversity; zoonoses; hosts

(This special issue belongs to the Section Infection Biology)

Plant Stress Physiology: A Trait Perspective

edited by Shuang-Xi Zhou,

Aoxue Wang

and Yanchang Wang

submission deadline 30 Jun 2026 | 2 articles | Viewed by 1025 | Submission Open

Keywords: photosynthetic traits; hydraulic traits; metabolic traits; stoichiometric traits; molecular traits; trait plasticity; trait adjustment; stress adaptation; climate resilience

(This special issue belongs to the Section Plant Science)

Latest Research in Cancer Multi-Omics

edited by Philip Anthony Sutera

submission deadline 30 Jun 2026 | 1 articles | Viewed by 972 | Submission Open

Keywords: cancer; multi-omics; genomics; transcriptomics; proteomics; metabolomics; radiomics; pathomics; precision medicine; artificial intelligence

(This special issue belongs to the Section Bioinformatics)

Metals in Biology (2nd Edition)

edited by

Muhamed Amin

submission deadline 30 Jun 2026 | Viewed by 961 | Submission Open

Keywords: metalloenzymes; iron sulfur cluster; mn cluster; photosystem I; photosystem II

Current Advances in Echinoderm Research (2nd Edition)

edited by

Muyan Chen

and

Xiutang Yuan

submission deadline 30 Jun 2026 | 1 articles | Viewed by 412 | Submission Open

Keywords: echinoderms; sea cucumbers; starfish; brittle stars; sea urchins

Interactions Between Membrane Proteins and Membrane Lipids

edited by

Youzhong Guo

submission deadline 30 Jun 2026 | Viewed by 388 | Submission Open

Keywords: membrane protein; lipid bilayer; enzyme; channel; receptor; transporter; cryo-EM; X-ray crystallography; structural biology; drug target

(This special issue belongs to the Section Biophysics)

Paper Collection: Understanding Immune Systems

edited by

Sigrun Lange

and Jameel M. Inal

submission deadline 30 Jun 2026 | Viewed by 358 | Submission Open

Keywords: immune mechanisms; evolutionary immunology; comparative immunology; innate immunity; adaptive immunity; autoimmunity; chronic inflammation; immune ageing; host– pathogen interactions; vaccinology; regenerative medicine

(This special issue belongs to the Section Immunology)

Vector-Borne Diseases: Host Infection Mechanisms, Immune Response and Epidemiology

edited by

Sahatchai Tangtrongsup

and

Nattawooti Sthitmatee

submission deadline 30 Jun 2026 | Viewed by 221 | Submission Open

Keywords: vector-borne pathogens; host– vector– pathogen interactions; immune response to arthropod-borne infections; vector competence and ecology; one health surveillance; emerging zoonoses; tick-borne diseases; animal vector-borne diseases; veterinary public health

(This special issue belongs to the Section Immunology)

Evolution, Genetics, and Conservation of Wildlife Respond to Environmental Changes

edited by Jiang Chang and

Shuping Wang

submission deadline 30 Jun 2026 | 1 articles | Viewed by 196 | Submission Open

Keywords: environmental change; wildlife; rapid evolution; genetic diversity; conservation genomics; environmental DNA; species distribution models; adaptive evolution; eco-evolutionary dynamics

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Advances in Research on Diseases of Plants (2nd Edition)

edited by

Wei Cheng

submission deadline 30 Jun 2026 | 2 articles | Viewed by 168 | Submission Open

Keywords: phytopathogen; plant immunity; plant disease resistance; gene expression/regulation; signal regulation; pathogenesis; virulence; genetic engineering; disease control

(This special issue belongs to the Section Plant Science)

Advances in Biological Breast Cancer Research (2nd Edition)

edited by Anna-Mart Engelbrecht,

Joji Mercier

and

Iman Van Den Bout

submission deadline 30 Jun 2026 | Viewed by 106 | Submission Open

Keywords: breast cancer; breast tumor; breast cancer cells; animal models; cell death; cancer diagnosis; cancer treatment; biomarkers; cancer microenvironment; carcinogens; estrogen receptor; molecular biology; cell biology

(This special issue belongs to the Section Cancer Biology)

Genomics and Bioinformatics in Microorganism from the Class Insecta

edited by Irám Pablo Rodríguez-Sánchez

submission deadline 30 Jun 2026 | Viewed by 73 | Submission Open

Keywords: genomics; bioinformatics; microbial communities; insect microbiomes; multi-omics; metagenomics; transcriptomics; host-microbe interactions; evolutionary dynamicsbiotechnological applications

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Precision Nutrition: Unraveling the Molecular Physiology of Nutrient–Gut–Health Axis in Livestock and Poultry

edited by Shengchen Wang, Tingting Li and Xiaoyan Cui

submission deadline 30 Jun 2026 | Viewed by 71 | Submission Open

Keywords: livestock; poultry; animal production; essential nutrients; bioactive compounds; metabolism; animal health; gut physiology; microbiota; molecular

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Genetic Breeding and Reproduction of Aquatic Animals—2nd Edition

edited by

Huaping Zhu

, Dongmei Ma and

Zaixuan Zhong

submission deadline 30 Jun 2026 | Viewed by 66 | Submission Open

Keywords: genetic breeding; reproduction technology; gene; protein; molecular marker; trait; QTLs; molecular marker; fish; shrimp; crab; shellfish; aquatic animals; transcriptomics; proteomics; metabonomics

(This special issue belongs to the Section Zoology)

Research Advances in Aquatic Omics

edited by

Zhengyong Wen

Qiong Shi

and Haiping Liu

submission deadline 30 Jun 2026 | Viewed by 55 | Submission Open

Keywords: aquatic animals; genomics; transcriptomics; proteomics; metabolomics; genetics; evolutionary biology

(This special issue belongs to the Section Evolutionary Biology)

Biology, Ecology and Management of Invasive Alien Plants (2nd Edition)

edited by

Guoqi Chen

and

Jiang Wang

submission deadline 30 Jun 2026 | Viewed by 49 | Submission Open

Keywords: changes in the composition and distribution of alien plants; invasive mechanisms; invasiveness; invasibility; invasive population; invasive plant interactions with other organisms; impacts on environment; ecosystem services and human health; chemical control; management of invasive plants; utilization of invasive plants

(This special issue belongs to the Section Plant Science)

Breaking Barriers in Metabolic Health: Novel Insights into Obesity and Metabolic Disorders

edited by Aijun Qiao

submission deadline 30 Jun 2026 | Viewed by 49 | Submission Open

Keywords: metabolic disorders; pathogenesis and mechanisms; biomarkers

(This special issue belongs to the Section Medical Biology)

Cytochrome P450s Across Biological Systems: From Molecular Mechanisms to Biotechnological and Biomedical Applications

edited by

Pradeepraj Durairaj

submission deadline 30 Jun 2026 | Viewed by 48 | Submission Open

Keywords: cytochrome P450 (CYP450); drug metabolism; xenobiotic metabolism; biocatalysis and biotransformation; orphan enzymes; redox biology; structural biology; synthetic biology; enzyme engineering; multi-omics approaches

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Yeasts Biotechnological Applications

edited by

Pornthap Thanonkeo

submission deadline 30 Jun 2026 | Viewed by 43 | Submission Open

Keywords: biofuel and feed production; biological control; waste treatment and utilization; yeast metabolites; enzyme technology; yeast strain development; process development

(This special issue belongs to the Section Biotechnology)

The Plasticity of Autonomic Ganglia

edited by

Miguel Angel Morales

submission deadline 30 Jun 2026 | Viewed by 39 | Submission Open

Keywords: acetylcholine; GABA; co-transmission; neuroplasticity; transmitter segregation; synapse; gLTP; binge-eating disorders; dysautonomia; heart disease

(This special issue belongs to the Section Neuroscience)

Nutritional Physiology of Animals

edited by

Bai Xue

Yuhong Gao

and Jia Zhou

submission deadline 30 Jun 2026 | Viewed by 37 | Submission Open

Keywords: animals; nutrition; feed additives; novel feed resources; physiology; digestibility; metabolism; stress; reproduction; multi-omics

(This special issue belongs to the Section Physiology)

Biosynthesis and Regulation of Plant Tissue-Specific Metabolites

edited by

Xiumin Fu

submission deadline 30 Jun 2026 | Viewed by 24 | Submission Open

Keywords: underground tissue metabolites; root; root exudates; genetic regulation; rhizosphere microbial interaction; environmental response

(This special issue belongs to the Section Plant Science)

Immune Response Regulation in Animals (2nd Edition)

edited by

Rong Gao

and

Hua-Ji Qiu

submission deadline 30 Jun 2026 | Viewed by 17 | Submission Open

Keywords: immunoregulation of animals; vaccination; immunomodulators; immune memory; cytokine; biotechnology; immune response; molecular networks

(This special issue belongs to the Section Immunology)

Research on the Interaction Mechanism Between Animal Intestine and Its Microbiota

edited by

Zongjie Li

and Xiaomin Guo

submission deadline 1 Jul 2026 | Viewed by 185 | Submission Open

Keywords: animal disease; innate immunity; gut microbiota; gut barrier; immune homeostasis

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Feature Papers in 'Conservation Biology and Biodiversity' (2nd Edition)

edited by

Ettore Randi

submission deadline 1 Jul 2026 | Viewed by 22 | Submission Open

Keywords: population genomics and diversity; heterozygosity; inbreeding; hybridization; adaptive introgression; natural selection; speciation; bottleneck and population fragmentation; genetic drift; gene flow; extinction risk; evolvability; paleogenomics; phylogeography; conservation units; ecotypes; phylogenetics and systematics; eDNA; non-invasive genetic sampling; environmental monitoring

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Microbial Responses, Pollutant Toxicity Mechanisms, and Human Health Implications

edited by

Chao Song

, Zhongquan Jiang and

Jiale Chen

submission deadline 10 Jul 2026 | Viewed by 132 | Submission Open

Keywords: heavy metal and emerging pollutants; microbiology and plant physiology; aquatic biology; environmental chemistry; anthropogenic disturbances; machine learning; pangenome analysis; computational toxicology; human health

Plant Natural Products: Mechanisms of Action for Promoting Health

edited by

Francisco Les

and

Guillermo Cásedas

submission deadline 31 Jul 2026 | 9 articles | Viewed by 12954 | Submission Open

Keywords: phytochemicals; bioactivity; therapeutics; mechanisms; health promotion; metabolism; enzyme activity; bioactive compounds; pharmacognosy; plant extracts; polyphenols; ethnopharmacology; essential oils; aromatic plants; antioxidants; natural products

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Dendrochronology in Arid and Semiarid Regions

edited by

Zongshan Li

submission deadline 31 Jul 2026 | 6 articles | Viewed by 11339 | Submission Open

Keywords: tree rings; growth– climate response; dendrochronology; dendroecology; dryland regions

(This special issue belongs to the Section Ecology)

Reproductive Physiology and Pathology in Livestock

edited by Claudio Gustavo Ustavo Barbeito and

Fabiano José Ferreira De Sant’Ana

submission deadline 31 Jul 2026 | 3 articles | Viewed by 5143 | Submission Open

Keywords: livestock; animal reproduction; reproductive biology; physiology and pathology of reproduction; experimental models; non-conventional species; biotechnology; immunology

(This special issue belongs to the Section Developmental and Reproductive Biology)

Human Leukocyte Antigen (HLA)—Antigen Interactions in Vaccine Development

edited by

Apostolos P. Georgopoulos

submission deadline 31 Jul 2026 | 2 articles | Viewed by 4753 | Submission Open

Keywords: HLA; vaccine; antigen; antibody; cancer; binding affinity; biophysical modeling; lymphocytes

Ecological Regulation of Forest and Grassland Pests

edited by

Dun Wang

and Liangjian Qu

submission deadline 31 Jul 2026 | 4 articles | Viewed by 4663 | Submission Open

Keywords: forest and grassland pests; ecological regulation; sustainable IPM; biological control; forest management

(This special issue belongs to the Section Ecology)

Unraveling the Molecular Mechanisms of Development and Stress Tolerance in Vegetables

edited by

Zhansheng Li

Jin Xu

and

Ying Li

submission deadline 31 Jul 2026 | 2 articles | Viewed by 4568 | Submission Open

Keywords: vegetable development; molecular mechanisms; stress tolerance; genetic regulation; epigenetic regulation; biochemical regulation; sustainable agriculture; environmental stress; growth adaptation; crop yield; gene editing; cellular engineering

(This special issue belongs to the Section Plant Science)

Animal Models of Metabolic Diseases

edited by

Júlio Cezar De Oliveira

and

Melvin Khee Shing Leow

submission deadline 31 Jul 2026 | 5 articles | Viewed by 4482 | Submission Open

Keywords: experimental models; metabolic syndrome; insulin resistance; type 2 diabetes mellitus; obesity; dyslipidemia; hypertension; metabolic programming; DOHaD

(This special issue belongs to the Section Physiology)

The Future of Marine Megafauna

edited by

Vincent L. Bels

and

John R. Turner

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2296 | Submission Open

Keywords: marine biodiversity; marine megafauna; anthropogenic impacts; conservation biology; marine ecosystems; behavioural ecology; marine protected areas (MPAs); ecological resilience; evolutionary biology; species recovery strategies

(This special issue belongs to the Section Zoology)

Osteoblast Differentiation in Health and Disease

edited by

Nadia Calabriso

and Maria Annunziata Carluccio

submission deadline 31 Jul 2026 | 2 articles | Viewed by 1562 | Submission Open

Keywords: osteogenesis; mesenchymal stem cells; osteoblast; osteoblast differentiation; bone diseases; transcription factors; epigenetics; extracellular vesicles; inflammatory mediators; bioactive natural compounds

(This special issue belongs to the Section Biochemistry and Molecular Biology)

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