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Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Plant Natural Products: Mechanisms of Action for Promoting Health

edited by

Francisco Les

and

Guillermo Cásedas

submission deadline 31 Jul 2026 | 11 articles | Viewed by 22700 | Submission Open

Keywords: phytochemicals; bioactivity; therapeutics; mechanisms; health promotion; metabolism; enzyme activity; bioactive compounds; pharmacognosy; plant extracts; polyphenols; ethnopharmacology; essential oils; aromatic plants; antioxidants; natural products

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Dendrochronology in Arid and Semiarid Regions

edited by

Zongshan Li

submission deadline 31 Jul 2026 | 6 articles | Viewed by 12509 | Submission Open

Keywords: tree rings; growth– climate response; dendrochronology; dendroecology; dryland regions

(This special issue belongs to the Section Ecology)

Animal Models of Metabolic Diseases

edited by

Júlio Cezar De Oliveira

and

Melvin Khee Shing Leow

submission deadline 31 Jul 2026 | 5 articles | Viewed by 7983 | Submission Open

Keywords: experimental models; metabolic syndrome; insulin resistance; type 2 diabetes mellitus; obesity; dyslipidemia; hypertension; metabolic programming; DOHaD

(This special issue belongs to the Section Physiology)

Reproductive Physiology and Pathology in Livestock

edited by Claudio Gustavo Ustavo Barbeito and

Fabiano José Ferreira De Sant’Ana

submission deadline 31 Jul 2026 | 5 articles | Viewed by 7068 | Submission Open

Keywords: livestock; animal reproduction; reproductive biology; physiology and pathology of reproduction; experimental models; non-conventional species; biotechnology; immunology

(This special issue belongs to the Section Developmental and Reproductive Biology)

Phytoplasmas: Molecular Characterization and Host–Pathogen Interactions (2nd Edition)

edited by

Wei Wei

submission deadline 31 Jul 2026 | 5 articles | Viewed by 6358 | Submission Open

Keywords: molecular diagnosis and epidemiology; host-phytoplasma interactions; genetic diversity; taxonomy and classification; ecology and evolution; insect vectors; disease management; phytoplasma genomics and other omics studies

(This special issue belongs to the Section Microbiology)

Milk Oligosaccharides: Biological Functions and Application Prospects

edited by

Chunsheng Jin

submission deadline 31 Jul 2026 | 3 articles | Viewed by 6137 | Submission Open

Keywords: milk oligosaccharides; colostrum; HMO; gut microbiota; immune modulator; prebiotics

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Human Leukocyte Antigen (HLA)—Antigen Interactions in Vaccine Development

edited by

Apostolos P. Georgopoulos

submission deadline 31 Jul 2026 | 4 articles | Viewed by 6090 | Submission Open

Keywords: HLA; vaccine; antigen; antibody; cancer; binding affinity; biophysical modeling; lymphocytes

Unraveling the Molecular Mechanisms of Development and Stress Tolerance in Vegetables

edited by

Zhansheng Li

Jin Xu

and

Ying Li

submission deadline 31 Jul 2026 | 3 articles | Viewed by 5882 | Submission Open

Keywords: vegetable development; molecular mechanisms; stress tolerance; genetic regulation; epigenetic regulation; biochemical regulation; sustainable agriculture; environmental stress; growth adaptation; crop yield; gene editing; cellular engineering

(This special issue belongs to the Section Plant Science)

Ecological Regulation of Forest and Grassland Pests

edited by

Dun Wang

and Liangjian Qu

submission deadline 31 Jul 2026 | 5 articles | Viewed by 5796 | Submission Open

Keywords: forest and grassland pests; ecological regulation; sustainable IPM; biological control; forest management

(This special issue belongs to the Section Ecology)

The Biodiversity and Ecosystem Dynamics of Deep-Sea Hydrothermal Vents

edited by

Xiang Zeng

and Yadong Zhou

submission deadline 31 Jul 2026 | 4 articles | Viewed by 4697 | Submission Open

Keywords: deep-sea hydrothermal vents; biodiversity; microbiome; biological resources; marine biology

(This special issue belongs to the Section Marine Biology)

The Relationship Between Water Quality and Aquatic Organisms (2nd Edition)

edited by Dong Zhang,

Ming Duan

Miao Wang

Xiangsheng Hong

and Mengmeng Yi

submission deadline 31 Jul 2026 | 3 articles | Viewed by 4371 | Submission Open

Keywords: aquatic animals; water quality; phytoplankton; zooplankton; microorganisms; physiology

The Future of Marine Megafauna

edited by

Vincent L. Bels

and

John R. Turner

submission deadline 31 Jul 2026 | 3 articles | Viewed by 3279 | Submission Open

Keywords: marine biodiversity; marine megafauna; anthropogenic impacts; conservation biology; marine ecosystems; behavioural ecology; marine protected areas (MPAs); ecological resilience; evolutionary biology; species recovery strategies

(This special issue belongs to the Section Zoology)

Osteoblast Differentiation in Health and Disease

edited by

Nadia Calabriso

and Maria Annunziata Carluccio

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2209 | Submission Open

Keywords: osteogenesis; mesenchymal stem cells; osteoblast; osteoblast differentiation; bone diseases; transcription factors; epigenetics; extracellular vesicles; inflammatory mediators; bioactive natural compounds

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Tickborne Diseases and Their Vectors

edited by Moses Sibusiso Mtshali

submission deadline 31 Jul 2026 | 2 articles | Viewed by 1889 | Submission Open

Keywords: ticks; tickborne pathogens; epidemiology of tickborne diseases; zoonotic diseases; molecular diagnosis; genetic diversity; immunology; vector control and mapping

(This special issue belongs to the Section Infection Biology)

Advances in Foodborne Pathogens

edited by Qiming Chen

submission deadline 31 Jul 2026 | 1 articles | Viewed by 918 | Submission Open

Keywords: foodborne pathogens; contamination mechanisms; infection mechanisms; detection assays; risk assessment; antibacterial agents or materials

(This special issue belongs to the Section Microbiology)

Advances in Microbial Enzyme Engineering

edited by

Thanongsak Chaiyaso

and Kamon Yakul

submission deadline 31 Jul 2026 | 1 articles | Viewed by 753 | Submission Open

Keywords: microbial enzyme engineering; lignocellulolytic enzymes; biorefinery applications; protein engineering; enzyme-based biomass conversion; synthetic biology

(This special issue belongs to the Section Microbiology)

Reprogramming Life: Synthetic Biology Approaches for Next-Gen Strain Engineering

edited by Thanaporn Laothanachareon,

Chitwadee Phithakrotchanakoon

and

Nunthaphan Vikromvarasiri

submission deadline 31 Jul 2026 | Viewed by 315 | Submission Open

Keywords: synthetic biology; strain engineering; metabolic pathway redesign; CRISPR/Cas genome editing; microbial cell factories; multi-omics integration; AI-driven metabolic design; sustainable bioproduction

(This special issue belongs to the Section Biotechnology)

Advances in Plant Genomics and Genome Editing

edited by Xuean Cui

submission deadline 31 Jul 2026 | Viewed by 313 | Submission Open

Keywords: plant genomes; plant genomics; genome sequencing; plant genome engineering; CRISPR/Cas; gene knock-out; gene knock-in; base editor; prime editor; genome editing tools; multiplex genome editing; gene expression regulation; plant trait improvement

(This special issue belongs to the Section Genetics and Genomics)

Environmental and Nutritional Stress: Metabolic Consequences and Regulatory Strategies in Animals

edited by

Wenqiang Ma

submission deadline 31 Jul 2026 | Viewed by 97 | Submission Open

Keywords: stress physiology; metabolic dysfunction; environmental stress; nutritional stress; gut microbiota; bioactive compounds

(This special issue belongs to the Section Physiology)

Epilepsy: The Mechanisms of Seizure, Termination, and Biomarker Development

edited by

Keisuke Maeda

submission deadline 31 Jul 2026 | Viewed by 55 | Submission Open

Keywords: epilepsy; epileptogenesis; seizure mechanisms; seizure dynamics; termination; biomarkers; neural excitability; neuroscience

(This special issue belongs to the Section Neuroscience)

Animal Cognition and Decision Strategies: From Behaviour to Computation

edited by

HaDi MaBouDi

and

Alice Bridges

submission deadline 31 Jul 2026 | Viewed by 54 | Submission Open

Keywords: animal models; bio-inspired computation; brain– behaviour mapping; cognitive mechanisms; cognitive neuroscience; cognitive strategies; comparative cognition; computational modelling; decision-making; learning and adaptation; naturalistic behaviour; neural computation; neuroethology

(This special issue belongs to the Section Neuroscience)

Regulation of Gene Expression in Immune Cell Development and Function

edited by Bon Quy Trinh

submission deadline 31 Jul 2026 | Viewed by 33 | Submission Open

Keywords: noncoding RNA; enhancer; silencer; transposable element; epigenetics; chromatin structure and architecture; innate immunology; adaptive immunology; development; functions

(This special issue belongs to the Section Immunology)

Ferroptosis: Mechanisms and Human Disease

edited by Chan-Yen Kuo

submission deadline 15 Aug 2026 | 3 articles | Viewed by 7024 | Submission Open

Keywords: ferroptosis; systemic diseases; inflammatory response; mitochondrial-dependent redox homeostasis; microenvironment

(This special issue belongs to the Section Cell Biology)

Role of CARD9 in Health and Diseases

edited by Zuberwasim Sayyad and Nikhil Sharma

submission deadline 15 Aug 2026 | Viewed by 72 | Submission Open

Keywords: CARD9; innate immunity; pattern recognition receptors; autophagy; apoptosis; inflammasome; reactive oxygen species; post-translational modifications; gut microbiota; inflammation and cancer

The Role of Autophagy and Macrophages in Modulating Immune Responses in Atherosclerosis

edited by

Kumar Prabhash Jha

and Aatira Vijay

submission deadline 25 Aug 2026 | Viewed by 72 | Submission Open

Keywords: atherosclerosis; macrophages; autophagy; immune regulation; chronic inflammation; plaque stability; lipid metabolism; efferocytosis; immunometabolism

Population Genetics and Conservation of Amphibians and Reptiles

edited by

Fang Yan

submission deadline 25 Aug 2026 | Viewed by 31 | Submission Open

Keywords: conservation genetics; local adaptation; genetic diversity; amphibian; reptile; environmental change

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Animal Models of Arthritis

edited by Nevena Arsenović-Ranin and Biljana Bufan

submission deadline 30 Aug 2026 | 4 articles | Viewed by 9230 | Submission Open

Keywords: animal models; rheumatoid arthritis; osteoarthritis; inflammation; immunopathology; pathological features; joints; treatment; drug screening; traditional medicine

(This special issue belongs to the Section Medical Biology)

Bone Cell Biology

edited by Yohei Abe and

Giulia Lanzolla

submission deadline 31 Aug 2026 | 7 articles | Viewed by 14026 | Submission Open

Keywords: osteoclast; osteoblast; osteocyte; bone density; macrophage; RANK; transcription factor; cell signaling

(This special issue belongs to the Section Cell Biology)

Editorial Board Members’ Collection Series: Pathology of Cancer and Cardiovascular Disease

edited by

Mridula Chopra

Helen L. Fillmore

and

Maurizio Forte

submission deadline 31 Aug 2026 | 2 articles | Viewed by 7518 | Submission Open

Keywords: cancer; cardiovascular disease; biomarkers; gut microbiome; inflammation; health policy; diet and lifestyle

Lipid Metabolism in Plant Growth and Development

edited by Xiaohong Yu and Yingqi Cai

submission deadline 31 Aug 2026 | 2 articles | Viewed by 3772 | Submission Open

Keywords: lipid metabolism; lipid engineering; plant growth; plant development; lipid biosynthesis; lipid signaling; lipid transport; membrane structure; energy storage; plant– microbe interactions; stress response; nutrition value; cellular process

(This special issue belongs to the Section Plant Science)

Cellular and Molecular Biology of Liver Diseases

edited by Matthew McMillin

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1204 | Submission Open

Keywords: drug-induced liver injury; cholestasis; hepatitis; metabolic dysfunction-associated steatotic liver disease; alcohol-associated liver disease

(This special issue belongs to the Section Cell Biology)

Regenerative Biology: Regeneration After Spinal Cord and Peripheral Nerve Injury

edited by

Alexandre Leite Rodrigues de Oliveira

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1079 | Submission Open

Keywords: neuronal regeneration; peripheral nerve repair; spinal cord injury; axonal growth; neuroplasticity; glial cells; molecular signaling pathways; stem cells in nerve regeneration; neuroinflammation; animal models of nerve injury

(This special issue belongs to the Section Neuroscience)

Host–Microbiome–Environment Interactions in Domestic and Wild Animals

edited by

Cesar A. Rosales-Nieto

and Cesar A. Meza-Herrera

submission deadline 31 Aug 2026 | 1 articles | Viewed by 995 | Submission Open

Keywords: animal microbiome; environmental microbiota; host– microbiota interactions; wildlife microbiology; livestock health and productivity; microbiome and conservation; One Health approach; gut microbiota dynamics; microbial ecology; microbiome and reproduction; habitat– host microbiome linkages; multi-omics integration

(This special issue belongs to the Section Microbiology)

Microbiology and Metabolomics in Reproductive Biology

edited by

Giuseppina Campisciano

submission deadline 31 Aug 2026 | Viewed by 327 | Submission Open

Keywords: maternal microbiome; metabolome; pregnancy outcomes; fetal development; biomarkers; immune function; metabolic health; disease prediction; therapeutic interventions; maternal and child health

(This special issue belongs to the Section Developmental and Reproductive Biology)

Advances in Cardiac and Vascular Biology: From Mechanisms to Pathophysiology

edited by

Hanqiang Deng

and

Haodi Wu

submission deadline 31 Aug 2026 | Viewed by 187 | Submission Open

Keywords: cardiovascular biology; molecular mechanisms; cellular signaling; epigenomic regulation; vascular remodeling; metabolic reprogramming; cardiac pathophysiology

(This special issue belongs to the Section Physiology)

Bone Mechanics: From Cells to Organs, to Function

edited by

Viviana Toro-Ibacache

submission deadline 31 Aug 2026 | Viewed by 106 | Submission Open

Keywords: bone mechanics; bone remodeling; mechanotransduction; structural analysis; functional morphology; bioengineering

(This special issue belongs to the Section Physiology)

Advances in Leishmaniasis and Chagas Disease: Biology, Epidemiology, Treatment and Control (2nd Edition)

edited by

Fernando Almeida-Souza

Flávia de Oliveira Cardoso

and

Kátia Da Silva Calabrese

submission deadline 31 Aug 2026 | Viewed by 106 | Submission Open

Keywords: leishmaniasis; Chagas disease; immunopathogeny; diagnosis; epidemiology; control; vaccine

Biophysics of Exposome: Molecular Mechanisms of Action

edited by

Judith Klein-Seetharaman

and Madhavi K. Ganapathiraju

submission deadline 31 Aug 2026 | Viewed by 89 | Submission Open

Keywords: computational biology; systems biology; mass spectrometry; protein– ligand networks; protein– protein interaction networks; metabolomics; proteomics; surface plasmon resonance; protein structure prediction; molecular docking; target fishing; machine learning; artificial intelligence

Fruits and Seeds of Tropical Plants: Conservation of Species, Ecological Importance and Quality Valorization

edited by Edna Ursulino Alves and Silvanda De Melo Silva

submission deadline 31 Aug 2026 | Viewed by 69 | Submission Open

Keywords: climate change; nature conservation; biodiversity; plant propagation; postharvest quality; metabolic profile; orchard management and quality

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Energy Metabolism, Genetics and Development in Drosophila

edited by

Do-Hwan Lim

submission deadline 31 Aug 2026 | Viewed by 58 | Submission Open

Keywords: Drosophila; energy metabolism; development; epigenetics; non-coding RNAs; metabolic disease; growth; signaling pathway

(This special issue belongs to the Section Bioinformatics)

Research Progress on Metabolic Pathways in Neurodegenerative Diseases

edited by Ali H. Rafati

submission deadline 31 Aug 2026 | Viewed by 46 | Submission Open

Keywords: neurodegeneration; metabolic dysfunction; mitochondrial impairment; oxidative stress; glucose metabolism; lipid metabolism; autophagy; neuroinflammation; biomarkers; therapeutic targets

(This special issue belongs to the Section Neuroscience)

Current Status and Future Perspectives on Lipid Biology and Beyond

edited by

Jasmina Debeljak Martacic

and

Slavica Ranković

submission deadline 31 Aug 2026 | Viewed by 35 | Submission Open

Keywords: lipids; fatty acids (FAs); omega-3 (FA); omega-6 (FA); cancer; cell biology; oxylipins; oxidative stress; lipidomics; lipid nanoparticles; personalized lipid-based therapies

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Biosynthesis of Metabolites from Microorganisms, or Microorganism-Host Interaction? (Volume II)

edited by

Fengli Zhang

Zhiqiang Liu

and

Michel Denis

submission deadline 1 Sep 2026 | 6 articles | Viewed by 15005 | Submission Open

Keywords: biosynthesis; biological activity; biosynthesis regulation; microbial metabolites; microbe– host reaction

(This special issue belongs to the Section Microbiology)

Viral Infections in Animals: Pathogenesis and Immunity

edited by

Yang Li

submission deadline 1 Sep 2026 | 1 articles | Viewed by 1133 | Submission Open

Keywords: virus– host interactions; antiviral immunity; mechanisms of viral pathogenesis

(This special issue belongs to the Section Immunology)

Latest Discoveries in Non-Model Organisms and Non-Translational Biology

edited by

Malgorzata Kloc

and

Jacek Z. Kubiak

submission deadline 8 Sep 2026 | Viewed by 71 | Submission Open

Keywords: basic biological research; non-translational biology; non-clinical biology; fundamental science; non-model organisms; model organisms; scientific curiosity– driven research; biological diversity; experimental biology; theoretical biology

Feature Papers on Developmental and Reproductive Biology

edited by

Jacek Z. Kubiak

submission deadline 15 Sep 2026 | 8 articles | Viewed by 18300 | Submission Open

Keywords: embryo/fetus development; reproductive biology; gametogenesis; differentiation; growth; homeostasis; regeneration; aging; cell cycle regulation; stem cells; organoids

(This special issue belongs to the Section Developmental and Reproductive Biology)

Plant Breeding: From Biology to Biotechnology

edited by Juwu Gong

submission deadline 30 Sep 2026 | 5 articles | Viewed by 6527 | Submission Open

Keywords: plant breeding; biotechnology; molecular marker-assisted selection; genetic engineering; genome editing; tissue culture; phenotype; genetics; omics

(This special issue belongs to the Section Biotechnology)

Molecular Basis of Bone Homeostasis and Skeletal Diseases

edited by

Weirong Xing

submission deadline 30 Sep 2026 | 3 articles | Viewed by 4895 | Submission Open

Keywords: osteoclast; osteoblast; bone; skeletal disease; bone formation; bone resorption; osteoporosis; osteopetrosis; human genetics; mouse genetics

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Signalling Pathways in Cancer and Disease

edited by

Ahmed Elbediwy

and

Nadine Wehida

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2439 | Submission Open

Keywords: cancer; signalling; metastasis; tumorigenesis; cancer targeting

(This special issue belongs to the Section Cancer Biology)

Research Advancements in Oral Biology

edited by

Jelena R. Roganović

and Nina Petrović

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2305 | Submission Open

Keywords: oral biology; oral tissue regeneration; artificial intelligence (AI) in dentistry; genomics and proteomics in dentistry; dental research; salivary diagnostics

(This special issue belongs to the Section Medical Biology)

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