Cytochrome P450s Across Biological Systems: From Molecular Mechanisms to Biotechnological and Biomedical Applications
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 2
Special Issue Editor
Interests: cytochrome p450 (cyp450); drug metabolism; xenobiotic-metabolizing enzymes; membrane proteins; biocatalysis; biotransformation; redox biology; pharmacogenomics; transcriptomics and proteomics; microbial biotechnology
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Special Issue Information
Dear Colleagues,
Cytochrome P450 enzymes (CYPs) constitute a highly diverse and evolutionarily conserved superfamily of heme-containing monooxygenases found across all domains of life. CYPs are renowned for their ability to catalyze diverse oxidation reactions critical to metabolism, hormone biosynthesis, and xenobiotic detoxification. Beyond their established role in human drug metabolism, recent advances have uncovered their broad physiological functions and remarkable catalytic versatility, fueling applications in biotechnology and synthetic biology.
This Special Issue aims to bring together cutting-edge research and reviews that deepen our understanding of CYP molecular mechanisms, regulatory networks, and biological roles, while highlighting their biotechnological and biomedical applications. We seek contributions that bridge fundamental biology with translational and applied sciences across diverse organisms and systems.
We welcome studies on the following topics:
- Structural and mechanistic insights into CYP catalysis and substrate specificity;
- Regulatory mechanisms controlling CYP expression and activity;
- Roles of CYPs in health, disease, and pharmacogenomics;
- Evolutionary diversity and adaptation of CYP enzymes;
- Engineering CYPs for improved catalysis and novel applications;
- Biotechnological uses in drug synthesis, green chemistry, and bioremediation;
- Computational approaches to predict and model CYP function.
We invite original research, reviews, perspectives, and methodological papers spanning biochemistry, molecular biology, pharmacology, biotechnology, and computational biology.
This Special Issue highlights innovative advances that deepen fundamental understanding and drive translational potential of cytochrome P450 enzymes.
Dr. Pradeepraj Durairaj
Guest Editor
Manuscript Submission Information
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Keywords
- cytochrome P450 (CYP450)
- drug metabolism
- xenobiotic metabolism
- biocatalysis and biotransformation
- orphan enzymes
- redox biology
- structural biology
- synthetic biology
- enzyme engineering
- multi-omics approaches
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