Mitochondria and Stress Responses

Dear Colleagues,

Mitochondria are generally known as the powerhouses of the cell. They play a central role in bioenergetics since they are the site of fatty acid β-oxidation, the tricarboxylic acid cycle, and oxidative phosphorylation. Mitochondria are also involved in various processes like pyrimidine synthesis, steroid hormone production, redox homeostasis, calcium storage, iron metabolism, etc. Mitochondria are involved in aging. They play a role in malignant tumor progression and respiratory chain dysfunctions, are responsible for multiple diseases referred to as mitochondriopathies, and defects in the mitochondrial network dynamics are associated with neurodegenerative disorders. According to this central position of mitochondria, various mechanisms involved in the quality control of the mitochondrial network have been selected during evolution. These mechanisms can operate at the protein level, using chaperones and proteases, at the organelle level (mitophagy), or at the cellular level (cell death). In addition to these responses to mitochondrial stress, mitochondria are also fully involved in the cell response to various stresses, such as DNA damage, viral infection, unbalanced proteostasis, and others. Notably, mitochondria are recognized today as central integrators of cell death and survival signals.

This Topical Collection entitled “Mitochondria and Stress Responses” aims to present articles focused on mitochondrial quality control mechanisms as well as on the role of mitochondria in cell stress responses. For example, articles dealing with subjects including but not restricted to mtUPR response, mitophagy, cell death processes involving mitochondria, and the crosstalk of mitochondria with other organelles are welcome, with an emphasis on recent developments in these fields. Original research and review articles are welcome.

Prof. Dr. Bernard Mignotte
Collection Editor

Manuscript Submission Information

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