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Bioengineering publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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AI-Driven Imaging and Analysis for Biomedical Applications

edited by

Netzahualcoyotl Hernandez-Cruz

, Ulas Bagci and

Zeyu Fu

submission deadline 31 Oct 2026 | 7 articles | Viewed by 8679 | Submission Open

Keywords: biomedical image and video analysis; ultrasound-based image and video analysis; machine learning; multimodal imaging; AI-assisted diagnostics; real-time analysis; generative AI; explainable AI

(This special issue belongs to the Section Biosignal Processing)

Biomedical Imaging and Data Analytics for Disease Diagnosis and Treatment, 3rd Edition

edited by

Cosimo Ieracitano

and

Xuejun Zhang

submission deadline 31 Oct 2026 | 4 articles | Viewed by 8407 | Submission Open

Keywords: artificial intelligence; machine learning; deep learning; biomedical engineering; medical image processing; data analytics

(This special issue belongs to the Section Biosignal Processing)

Orthopedic and Trauma Biomechanics

edited by

Ligia Rusu

Nejc Šarabon

and

Mihnea Ion Marin

submission deadline 31 Oct 2026 | 6 articles | Viewed by 5904 | Submission Open

Keywords: biomechanics; gait; trauma and biomechanics; movement; orthopedic assessment

(This special issue belongs to the Section Biomechanics and Sports Medicine)

Tendon/Ligament and Enthesis Injuries: Repair and Regeneration

edited by Dai Fei Elmer Ker, Jingyu Shi and Bingyang Dai

submission deadline 31 Oct 2026 | 2 articles | Viewed by 4506 | Submission Open

Keywords: tendon; ligament; enthesis; drug delivery; therapeutics; biomaterials; tissue engineering; musculoskeletal animal models

(This special issue belongs to the Section Regenerative Engineering)

Stem Cell Immunoengineering

edited by Yun Chang

submission deadline 31 Oct 2026 | 1 articles | Viewed by 4073 | Submission Open

Keywords: stem cell; immunoengineering; immune cells; genetic and epigenetic programming; biomaterials; delivery system

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Next-Generation Biomaterials and Regenerative Strategies for Precision Tissue Engineering

edited by

Ali R. Djalilian

and

Zohreh Arabpour

submission deadline 31 Oct 2026 | 3 articles | Viewed by 3492 | Submission Open

Keywords: biomaterials; tissue engineering; regenerative medicine; cell therapy; 3D/4D printing; biofabrication

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Machine Learning in Biomedical Research: Application, Innovation and Exploration

edited by

Fangyao Chen

Xianjun Li

and Wu Qiu

submission deadline 31 Oct 2026 | 4 articles | Viewed by 3397 | Submission Open

Keywords: artificial intelligence; machine learning; biomedical data mining; precision medicine and health; disease diagnosis and prediction; drug discovery and screening

(This special issue belongs to the Section Biosignal Processing)

Engineering the Future of Radiotherapy: Innovations and Challenges

edited by

Kalliopi Platoni

and

Vassilis Kouloulias

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3019 | Submission Open

Keywords: radiosurgery; stereotactic radiotherapy; proton therapy; artificial intelligence (AI); flash therapy; image/surface-guided radiotherapy; nanoparticles

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advances in Robotic-Assisted Rehabilitation

edited by

Hongwu Wang

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2508 | Submission Open

Keywords: robotics-assisted rehabilitation; neurological rehabilitation robotics; wearable robotics; exoskeletons and assistive robotics; adaptive control in robotics; human– robot interaction; AI and machine learning in rehabilitation; translational studies in rehabilitation robotics; ethical considerations in rehabilitation robotics

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Oral and Maxillofacial Regeneration and Restoration

edited by

Soo-Hwan Byun

Byoung-Eun Yang

and

Sang-Yoon Park

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1685 | Submission Open

Keywords: bone regeneration; tissue regeneration; digital dentistry; customized restoration; oral and maxillofacial reconstruction

(This special issue belongs to the Section Regenerative Engineering)

Biomedical Engineering Approaches for Non-Invasive Monitoring in Hypovolemia and Hypotension

edited by

Eric J. Snider

and

Victor A. Convertino

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1527 | Submission Open

Keywords: physiological monitoring; non-invasive monitoring; blood pressure estimation; advanced monitoring; machine learning; deep learning; artificial intelligence

(This special issue belongs to the Section Biosignal Processing)

Basics and Mechanisms of Different Neuromodulation Devices

edited by

Alaa Abd-Elsayed

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1444 | Submission Open

Keywords: spinal cord stimulation; peripheral nerve stimulation; deep brain stimulation; vagal nerve stimulation; gastric stimulators; sacral stimulators; neuromodulation; basics; mechanism of action

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advancements in Physical Therapy and Rehabilitation: Neuromodulation, MRI-Based Neuroimaging and Functional Restoration Devices

edited by Alessandro Napoli, Laura Krisa and Mahdi Alizadeh

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1043 | Submission Open

Keywords: neuromodulation; neurorestoration; advanced rehabilitation; functional restoration device

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Machine Learning in Ultrasound Imaging

edited by Laura Brattain, Vivek Singh and Md Mostafa Kamal Sarker

submission deadline 31 Oct 2026 | Viewed by 870 | Submission Open

Keywords: computer-aided diagnosis; medical image analysis; image segmentation; procedural guidance; clinical decision support; elastography; contrast-enhanced ultrasound; point-of-care ultrasound (POCUS); multimodal imaging

(This special issue belongs to the Section Biosignal Processing)

Biomedical Engineering Strategies for Scoliosis Treatment

edited by Pier Francesco Costici and Sergio De Salvatore

submission deadline 31 Oct 2026 | Viewed by 328 | Submission Open

Keywords: scoliosis; AIS; gait analysis; posture analysis; spine surgery

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Soft Tissue Reconstruction and Repair

edited by

Michalis P. Katsimpoulas

submission deadline 31 Oct 2026 | Viewed by 310 | Submission Open

Keywords: vascularization; soft tissue reconstruction; biomaterials; tissue engineering; hydrogels

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Gene Therapies for Regenerative Medicine

edited by

Eddie Han Pin Tan

and

Yie Hou Lee

submission deadline 31 Oct 2026 | Viewed by 278 | Submission Open

Keywords: cell therapy; gene therapy; regenerative medicine; gene delivery; stem cell engineering; tissue engineering; biomaterials; cell reprogramming; viral vectors

(This special issue belongs to the Section Cellular and Molecular Bioengineering)

Innovative Tools for Muscular Assessment

edited by Ross Alan Bogey

submission deadline 31 Oct 2026 | Viewed by 269 | Submission Open

Keywords: muscle force; muscle power; sarcopenia; muscle function; aging and atrophy

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Periodontics and Implant Dentistry—2nd Edition

edited by

Sergio Alexandre Gehrke

submission deadline 31 Oct 2026 | Viewed by 263 | Submission Open

Keywords: periodontics; implantology; technological advances; periodontal health; dental implants; digital planning; guided tissue regeneration; laser therapy; biomaterials; minimally invasive therapies; 3D printing; artificial intelligence; cone beam computed tomography (CBCT); biomodulation; peri-implantitis; tissue engineering; sustainability in dentistry; stem cells; bioprinting; oral rehabilitation

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

AI-Powered Diagnosis and Treatment Plans in Dentistry and Orofacial Fields, 2nd Edition

edited by

Antonino Lo Giudice

, Rosalia Leonardi,

Victor Díaz-Flores García

and

Yolanda Freire

submission deadline 31 Oct 2026 | Viewed by 254 | Submission Open

Keywords: artificial intelligence; AI; digital dentistry; digital systems; CBCT; CAD-CAM

(This special issue belongs to the Section Biosignal Processing)

Advances in Non-Invasive and Hybrid Brain–Computer Interfaces: Signal Processing, AI, and Emerging Semantic Decoding

edited by

Luca Mesin

submission deadline 31 Oct 2026 | Viewed by 245 | Submission Open

Keywords: brain– computer interface (BCI); electroencephalography (EEG); non-invasive BCI; hybrid BCI (EEG– EMG); EEG signal processing; artifact removal; time– frequency analysis; EEG decoding; deep learning for EEG; cross-subject generalization; domain adaptation; semantic decoding; intention recognition

(This special issue belongs to the Section Biosignal Processing)

Bioengineering Born from Medical-Engineering Collaboration

edited by

Satoshi Komasa

submission deadline 31 Oct 2026 | Viewed by 203 | Submission Open

Keywords: medical-engineering collaboration; clinical needs; regenerative medicine; biomaterials; tissue engineering; medical device development

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advanced Technique for Endoscopic Diagnosis in Biomedical Engineering

edited by Changseok Bang

submission deadline 31 Oct 2026 | Viewed by 161 | Submission Open

Keywords: endoscopic diagnosis; gastroenterology; novel technique; precision medicine; minimally invasive; patient- friendly; state-of-the-art technology; gastrointestinal disorders; diagnostic accuracy; artificial intelligence; research innovation

(This special issue belongs to the Section Biosignal Processing)

Application of Bioengineering to Implant Dentistry—2nd Edition

edited by Umadevi Kandalam

submission deadline 31 Oct 2026 | Viewed by 156 | Submission Open

Keywords: implant dentistry; restorative dentistry; bioengineering; biomaterials; craniofacial regeneration; tissue engineering; biomechanics

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Artificial Intelligence in Cardiovascular Disease: From Diagnosis to Intervention and Quality Improvement

edited by

Dimitrios E. Magouliotis

, Serge Sicouri and Alexandra Bekiaridou

submission deadline 31 Oct 2026 | Viewed by 156 | Submission Open

Keywords: artificial intelligence; machine learning; cardiovascular imaging; risk stratification; clinical decision support; predictive modeling; perioperative outcomes; quality improvement

(This special issue belongs to the Section Biosignal Processing)

Imaging-Guided Advanced Nanomaterials for Precision Cancer Immunotherapy

edited by

Praveen Kumar Panangattukara Prabhakaran

and

Dong-Kwon Lim

submission deadline 31 Oct 2026 | Viewed by 145 | Submission Open

Keywords: cancer immunotherapy; nanomedicine; bioimaging; molecular imaging; imaging-guided immunotherapy; advanced nanomaterials; tumor microenvironment; immune modulation; immune-responsive nanomaterials; combination immunotherapy; translational nanotechnology

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Deep Learning for Positron Emission Tomography (PET) Imaging and Signal Analysis

edited by

Siwei Xie

and

Zhen Cheng

submission deadline 31 Oct 2026 | Viewed by 120 | Submission Open

Keywords: deep learning; positron emission tomography (PET) * image reconstruction; signal analysis; molecular imaging

(This special issue belongs to the Section Biosignal Processing)

Advances in Ocular Diagnosis and Therapy

edited by

Karanjit S. Kooner

submission deadline 31 Oct 2026 | Viewed by 46 | Submission Open

Keywords: glaucoma; cataracts; macular degeneration; uveitis; artificial intelligence; retinal imaging; corneal imaging; teleophthalmology; ocular drug delivery; ocular micro-devices; ocular gene and stem cell therapy; ocular biomarkers

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advances in MRI Techniques and Neuropsychiatric Applications

edited by Haoyang Xing and Neil Roberts

submission deadline 31 Oct 2026 | Viewed by 42 | Submission Open

Keywords: magnetic resonance imaging (MRI); neuroimaging; disease assessment; neuromodulation

(This special issue belongs to the Section Biosignal Processing)

Innovative Biomaterials and Advanced Technologies in Bone Tissue Regeneration

edited by

Natalia Di Pietro

submission deadline 1 Nov 2026 | 4 articles | Viewed by 8424 | Submission Open

Keywords: biomaterials; bone tissue regeneration; tissue engineering; scaffolds; prosthetics; dental implants; osseointegration; numerical studies; biomechanics; digital dentistry

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Biotechnological Advances for Waste and Wastewater Valorisation: From Bioprocesses to Sustainable Resource Recovery

edited by Marco Gottardo, Andrea Pietrelli and Angela Marchetti

submission deadline 1 Nov 2026 | Viewed by 210 | Submission Open

Keywords: bioelectrochemical systems; sustainable bioprocesses; waste-to-value conversion; circular resource management; integrated biorefineries; biohydrogen production; added-value products

(This special issue belongs to the Section Biochemical Engineering)

Advanced Biomaterials for 3D Bioprinting and Tissue Engineering

edited by Fuke Wang and

Sirawit Pruksawan

submission deadline 16 Nov 2026 | Viewed by 45 | Submission Open

Keywords: 3D/4D printing; bioprinting; tissue engineering; bioactive materials

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Smart Polymer Hydrogels for Advanced Biomedical Applications

edited by

Yongfeng Gao

submission deadline 20 Nov 2026 | Viewed by 316 | Submission Open

Keywords: smart hydrogels; stimuli-responsive polymers; drug delivery systems; tissue engineering; regenerative medicine; biosensors; biocompatibility; controlled release; biomedical materials; supramolecular hydrogels

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Next-Generation Spine Surgery: Innovation at the Intersection of Biology and Engineering

edited by

Najib E. El Tecle

submission deadline 20 Nov 2026 | Viewed by 264 | Submission Open

Keywords: spinal reconstruction; smart implants; robotic surgery; biomechanical modeling

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advanced 3D Cell Culture Technologies and Formats—3rd Edition

edited by

Cornelia Kasper

and

Janina Bahnemann

submission deadline 25 Nov 2026 | Viewed by 156 | Submission Open

Keywords: 3D cell culture; bioreactors; tissue engineering

(This special issue belongs to the Section Regenerative Engineering)

Explainable Artificial Intelligence (XAI) in Medical Imaging

edited by

Quincy A. Hathaway

and

Yashbir Singh

submission deadline 30 Nov 2026 | 3 articles | Viewed by 12895 | Submission Open

Keywords: Explainable Artificial Intelligence (XAI); medical imaging; SHAP/LIME/Grad-CAM

(This special issue belongs to the Section Biosignal Processing)

Microalgae Biotechnology and Microbiology: Prospects and Applications

edited by Dora Allegra Carbone and Michael Melkonian

submission deadline 30 Nov 2026 | 5 articles | Viewed by 7091 | Submission Open

Keywords: microalgae; bacteria; photobioreactor; bioengineering; biomass; wastewater; compounds

(This special issue belongs to the Section Biochemical Engineering)

Computational Intelligence for Healthcare

edited by

Jiaojiao Wang

, Chee Wei Tan and Qingpeng Zhang

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3935 | Submission Open

Keywords: artificial intelligence; big data analytics; generative models; pathogen tracking and tracing; chronic disease prediction and management; predictive modeling; bioinformatics; pandemic preparedness; IoT-enabled biosensors; health disparities and ethics; multi-modal data fusion

(This special issue belongs to the Section Biosignal Processing)

Advances in Peptide Delivery: Strategies, Formulations, and Therapeutic Applications

edited by

Qi Xiang

submission deadline 30 Nov 2026 | 1 articles | Viewed by 857 | Submission Open

Keywords: peptide therapeutics; drug delivery systems; bioavailability; formulation strategies; nanoparticles; cell-penetrating peptides (CPPs); non-invasive delivery; targeted delivery; stability enhancement; pharmacokinetics

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Machine Learning and Artificial Intelligence for Biostatistics

edited by Muktar Beshir Ahmed and

Mehdi Neshat

submission deadline 30 Nov 2026 | Viewed by 509 | Submission Open

Keywords: artificial intelligence; machine learning; biostatistics; medical image analysis; biosignal processing; bioinformatics; deep learning; biomedical data science; clinical prediction; statistical learning

(This special issue belongs to the Section Biosignal Processing)

AI- and ML-Assisted Biosensing and Microfluidics Applications in Biotechnology

edited by

Rossana Madrid

submission deadline 30 Nov 2026 | Viewed by 236 | Submission Open

Keywords: artificial intelligence; biosensors; microfluidics; agriculture; food safety; point-of-care applications

(This special issue belongs to the Section Biosignal Processing)

Artificial Intelligence (AI) in Bioengineering: Second Edition

edited by William C. Tang

submission deadline 30 Nov 2026 | Viewed by 207 | Submission Open

Keywords: artificial intelligence; bioengineering; computational models; intelligent algorithms; biologically inspired systems; healthcare; diagnostics; personalized medicine; medical imaging analysis; biomedical signal processing; drug discovery and development; smart prosthetics and assistive technologies; clinical decision-making

(This special issue belongs to the Section Biosignal Processing)

Bioengineering Liver Transplantation—3rd Edition

edited by

Monique M. A. Verstegen

submission deadline 30 Nov 2026 | Viewed by 203 | Submission Open

Keywords: liver regeneration; liver stem cells and organoids; liver tissue engineering; graft repair; bioscaffolds; bioprinting

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Wearable and Portable Sensors for Cardiovascular Care

edited by

Laura Burattini

and

Agnese Sbrollini

submission deadline 30 Nov 2026 | Viewed by 162 | Submission Open

Keywords: wearable sensors; portable monitoring systems; cardiovascular care; biomedical signal processing; ECG and PPG; continuous and remote monitoring; telecardiology; clinical decision support

(This special issue belongs to the Section Biosignal Processing)

Orthopaedic Bioengineering and Tissue Regeneration: Second Edition

edited by

David Putzer

submission deadline 30 Nov 2026 | Viewed by 118 | Submission Open

Keywords: orthopaedic bioengineering; implant surfaces; biological response of implant surfaces; bone remodelling; bioprinted scaffolds

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Stem Cell Therapy in Disease and Regenerative Medicine

edited by

Rishi Man Chugh

and Rajnikant Sharma

submission deadline 30 Nov 2026 | Viewed by 72 | Submission Open

Keywords: stem cell therapy; regenerative medicine; tissue repair and regeneration; immunomodulation; fibrosis and chronic disease; infection and host response; translational and precision medicine

(This special issue belongs to the Section Regenerative Engineering)

Bioengineering Approaches to Microalgae-Based Systems

edited by

Eduardo Jacob-Lopes

and Mariane Bittencourt Fagundes

submission deadline 1 Dec 2026 | Viewed by 205 | Submission Open

Keywords: metabolic engineering; cellular systems; bioprocess and bioproducts; multi-scale strategies; modeling and optimization; sustainable biotechnology; translational applications

(This special issue belongs to the Section Biochemical Engineering)

Rehabilitative Assessment Approaches for Disabilities

edited by

Saeid Sanei

and Tracey KM Lee

submission deadline 30 Dec 2026 | Viewed by 182 | Submission Open

Keywords: biosignal processing; deep learning; body sensor networks; gait; EEG; EMG; machine learning; rehabilitative assessment; vision techniques

(This special issue belongs to the Section Biosignal Processing)

Artificial Intelligence in Plastic and Reconstructive Surgery: Innovations and Clinical Applications

edited by Cesar Abraham Gomez-Cabello and

Antonio Jorge Forte

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2617 | Submission Open

Keywords: artificial intelligence; machine learning; plastic surgery; reconstructive surgery; surgical planning; risk stratification; outcome prediction; postoperative monitoring

(This special issue belongs to the Section Biosignal Processing)

Transcranial Direct Current Stimulation: Bridging Bioengineering and Neuroscience for Brain Health

edited by