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Bioengineering publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advancements in Imaging Techniques for Assessing Bone Health and Regeneration

edited by William Querido

submission deadline 31 Dec 2025 | Viewed by 75 | Submission Open

Keywords: bone imaging techniques; multimodal and spectral imaging; high-resolution microscopy and tomography; advanced bone histopathology; bone composition and microarchitecture; machine learning in biomedical imaging

(This special issue belongs to the Section Biosignal Processing)

Biological Wastewater Treatment and Resource Recovery, 2nd Edition

edited by

Omprakash Sarkar

Naresh Kumar Amradi

and J. Shanthi Sravan

submission deadline 31 Dec 2025 | Viewed by 73 | Submission Open

Keywords: wastewater treatment; nutrient recovery; bioenergy generation; biobased products; anaerobic digestion; volatile fatty acids; bioammonium; bioelectricity

(This special issue belongs to the Section Biochemical Engineering)

Advanced Polymeric Materials for Bone, Cartilage, and Skeletal Muscle Regeneration

edited by

Jian Li

submission deadline 31 Dec 2025 | Viewed by 68 | Submission Open

Keywords: polymeric materials; bone regeneration; cartilage repair; skeletal muscle regeneration; 3D bioprinting; drug delivery systems; biodegradable polymers; smart materials

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Bioengineering Technologies for Spine Research

edited by Hyoungmin Kim

submission deadline 31 Dec 2025 | Viewed by 60 | Submission Open

Keywords: spine biomechanics; spinal implants and devices; computational modeling; tissue engineering; biomedical imaging; artificial intelligence; motion analysis; surgical robotics; regenerative medicine; predictive modeling; personalized spine care; translational bioengineering; smart materials; image-guided interventions

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Oral Wound Healing and Material Engineering

edited by

Steven L. Goudy

submission deadline 31 Dec 2025 | Viewed by 60 | Submission Open

Keywords: oral; healing; regeneration; mucosa; bone; biomaterial

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Gene Delivery for Cancer Therapy

edited by Huiyi Liang and Tianqi Nie

submission deadline 10 Jan 2026 | Viewed by 215 | Submission Open

Keywords: gene delivery; drug delivery; nanoparticles; hydrogel; cancer

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Transformative Technologies for Bioengineering and Regenerative Medicine

edited by

Salil Desai

and Joshua Hunsberger

submission deadline 10 Jan 2026 | 1 articles | Viewed by 214 | Submission Open

Keywords: regenerative medicine; tissue engineering; artificial intelligence; digital twins; IIoTs; biomaterials; biomanufacturing; cybersecurity

(This special issue belongs to the Section Regenerative Engineering)

Electrical Impedance Tomography: New Advances in Biomedical Signal Processing

edited by Meng Dai

submission deadline 12 Jan 2026 | 2 articles | Viewed by 1014 | Submission Open

Keywords: electrical impedance tomography (EIT); signal processing; clinical noises; body movement; radiation-free imaging; image reconstruction; machine learning; artificial intelligence; real-time EIT; quantitative EIT

(This special issue belongs to the Section Biosignal Processing)

Development and Application of Extracellular Vesicles for Neurodegenerative Diseases

edited by Mangesh Dattu Hade

submission deadline 12 Jan 2026 | Viewed by 190 | Submission Open

Keywords: extracellular vesicles (EVs); neurodegenerative diseases; exosomes; blood– brain barrier; biomarkers; therapeutic nanocarriers

(This special issue belongs to the Section Regenerative Engineering)

Tumor Mechanobiology and Translational Insights

edited by

Yousef Javanmardi

submission deadline 15 Jan 2026 | Viewed by 227 | Submission Open

Keywords: tumor mechanobiology; tumor microenvironment; mechanotransduction; ECM remodeling; tissue mechanics; translational mechanobiology

(This special issue belongs to the Section Cellular and Molecular Bioengineering)

Design and Synthesis of Functional Deuterated Biomaterials

edited by Nageshwar R. Yepuri

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1928 | Submission Open

Keywords: deuterated lipids; deuterated phospholipids; lipid nano particle; lipid nano discs; deuterated fatty acids; deuterated amino acids

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Engineering Stem Cells and Their Derivatives for Wound Healing and Tissue Regeneration

edited by Yueh Hsun Kevin Yang

submission deadline 25 Jan 2026 | Viewed by 58 | Submission Open

Keywords: stem cells; extracellular vesicles; biomaterials; immunoengineering; gene editing; regenerative medicine; wound healing

(This special issue belongs to the Section Regenerative Engineering)

New Sight for the Treatment of Dental Diseases: Updates and Direction

edited by

Angelo Michele Inchingolo

submission deadline 31 Jan 2026 | 4 articles | Viewed by 29285 | Submission Open

(This special issue belongs to the Section Regenerative Engineering)

Technological Advances for Gait and Balance Assessment

edited by Alessandro Zampogna,

Silvia Del Din

and

Florenc Demrozi

submission deadline 31 Jan 2026 | 5 articles | Viewed by 6385 | Submission Open

Keywords: novel diagnostic devices and wearable sensors; machine learning and artificial intelligence applications; biomechanical analysis; telemedicine and remote monitoring solutions

(This special issue belongs to the Section Biosignal Processing)

Advanced Technology for Implant Polymers in Orthopaedics, Spine, and Trauma

edited by Steven M. Kurtz, Hannah Spece,

Pierangiola Bracco

and

Francisco Javier Medel

submission deadline 31 Jan 2026 | 3 articles | Viewed by 6095 | Submission Open

Keywords: UHMWPE; highly crosslinked UHMWPE; HXLPE; PEEK; PEKK; PAEK; additive manufacturing; AM; 3D printing

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Dynamic Insights: Unveiling the Biomechanics of Sport Through Motion Analysis

edited by

Ukadike Chris Ugbolue

and Sang-Hoon Yeo

submission deadline 31 Jan 2026 | 4 articles | Viewed by 5090 | Submission Open

Keywords: artificial intelligence; augmented reality; biomechanics; E-sports; instrumentation; kinesiology; machine learning; motion analysis; performance enhancement; virtual reality; wearable technology

(This special issue belongs to the Section Biomechanics and Sports Medicine)

Medical Imaging Analysis: Current and Future Trends

edited by He Zhao and

Lin Gu

submission deadline 31 Jan 2026 | 5 articles | Viewed by 4100 | Submission Open

Keywords: computer vision; artificial intelligence (AI); multi-modality learning; disease progression monitoring; explainable AI; human-computer interaction

(This special issue belongs to the Section Biosignal Processing)

Disease Diagnosis and Therapy Using Viral Vectors

edited by

Srividhya Venkataraman

and

Kathleen Hefferon

submission deadline 31 Jan 2026 | 1 articles | Viewed by 3200 | Submission Open

Keywords: gene therapy; viral vectors; genetic disease

(This special issue belongs to the Section Cellular and Molecular Bioengineering)

Innovative Bioengineering Paradigms for Cardiac Repair: Cell-Based and Cell-Free Approaches

edited by

Jialiang Liang

and Xingyu He

submission deadline 31 Jan 2026 | 3 articles | Viewed by 3154 | Submission Open

Keywords: cardiac regeneration; cardiac repair; stem cells; tissue engineering; cell transplant; gene delivery; extracellular vesicles; nanotechnology; immunomodulation; lineage reprogramming

(This special issue belongs to the Section Regenerative Engineering)

Bioengineering in a Generative AI World

edited by

Yifan Zhao

, Ulas Bagci and Yuxiang Zhou

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2361 | Submission Open

Keywords: generative AI; bioengineering; machine learning; synthetic biology; drug discovery

(This special issue belongs to the Section Biosignal Processing)

New Sights of Mathematical Modeling in Biomedicine: Updates and Direction

edited by

Kayode Oshinubi

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1943 | Submission Open

Keywords: mathematical modeling; machine learning; predictive modeling; data modeling; biological systems

(This special issue belongs to the Section Biosignal Processing)

Low-Back Pain: Assessment and Rehabilitation Research

edited by

Giustino Varrassi

and

Giacomo Farì

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1347 | Submission Open

Keywords: chronic pain; wearable technologies; computational modeling; biomechanical analysis; assistive devices; sensor-based functional assessments

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Biomedical Engineering and Biomarkers in Plastic and Reconstructive Surgery Applications

edited by Saif Badran and Matthew Wood

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1317 | Submission Open

Keywords: tissue engineering; 3D bioprinting; personalized medicine; metabolic biomarkers; regenerative medicine; advanced biomaterials

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Digital Technologies to Improve Diagnostic Cytopathology: Future Outlook

edited by

Enrico Giarnieri

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1304 | Submission Open

Keywords: machine learning; cytopathology; digital cytology; computer-aided diagnosis; virtual reality; natural language process

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Data Modeling and Algorithms in Biomedical Applications

edited by

Ivan Ganchev Ivanov

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1052 | Submission Open

Keywords: computer models; algorithms; biomedical applications; predictive modeling; machine learning; data analysis; data modeling; AI applications

(This special issue belongs to the Section Biosignal Processing)

Recent Advances in Periodontal Tissue Engineering

edited by

Atsushi Saito

submission deadline 31 Jan 2026 | 1 articles | Viewed by 988 | Submission Open

Keywords: periodontal disease; periodontal tissue engineering; periodontal regeneration; biomaterials; soft and hard tissue regeneration

(This special issue belongs to the Section Regenerative Engineering)

Radiation Imaging and Therapy for Biomedical Engineering

edited by Bharat Guthikonda and Stanley Hoang

submission deadline 31 Jan 2026 | 1 articles | Viewed by 572 | Submission Open

Keywords: radiation imaging; radiation therapy; biomedical engineering; diagnostic technologies; therapeutic innovations

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Printable Biomaterials from Tissue Engineering to Orthopedics: Fabrication, Mechanical Performance, and Biological Behavior

edited by

Gianpaolo Serino

and

Gulden Camci-Unal

submission deadline 31 Jan 2026 | 1 articles | Viewed by 529 | Submission Open

Keywords: advanced printable biomaterials; biocompatibility; bioactivity; mechanical properties; physical and chemical properties

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Artificial Intelligence in Neurodegenerative Disorders: Advances in Diagnosis, Prognosis and Treatment

edited by Shayne Chau and Mohd. Farooq Shaikh

submission deadline 31 Jan 2026 | Viewed by 392 | Submission Open

Keywords: artificial intelligence; neurodegenerative disorders; machine learning in neurology; diagnosis; treatment; prognosis

(This special issue belongs to the Section Biosignal Processing)

Deep Learning for Medical Applications: Challenges and Opportunities

edited by

Roberta Hlavata

, Robert Hudec and

Patrik Kamencay

submission deadline 31 Jan 2026 | Viewed by 364 | Submission Open

Keywords: deep neural networks; deep learning; machine learning; medical applications; healthcare AI; medical imaging; multimodal data integration; model interpretability

(This special issue belongs to the Section Biosignal Processing)

Neuroimaging Techniques for Central Autonomic System: Methodologies and Applications

edited by Antonio Ferretti and Mauro Gianni Perrucci

submission deadline 31 Jan 2026 | Viewed by 323 | Submission Open

Keywords: integration of EEG; fMRI; fNIRS; or other neuroimaging modalities; fMRI preprocessing; autonomic system; central autonomic network; physiological noise; brainstem; epilepsy; sudep; valsalva maneuver; functional connectivity; integration of neuroimaging and extended-reality protocols

(This special issue belongs to the Section Biosignal Processing)

Emerging Artificial Intelligence Trends for Predictive Analytics and Personalized Healthcare

edited by

Josu Maiora

Maria Begoña Sanz Echevarría

and

Manuel Graña

submission deadline 31 Jan 2026 | Viewed by 315 | Submission Open

Keywords: artificial intelligence; machine learning; deep learning; predictive analytics; wearable sensors; medical devices; medical image analysis

(This special issue belongs to the Section Biosignal Processing)

New Sights of AI Tools and Deep Learning in Biomedicine

edited by

Mirpouya Mirmozaffari

submission deadline 31 Jan 2026 | Viewed by 244 | Submission Open

Keywords: artificial intelligence; machine learning; optimization; healthcare management; operation research; biomedicine

(This special issue belongs to the Section Biosignal Processing)

Dental Pulp Stem Cells in Clinical Application: Present and Future Perspectives

edited by

Ciro Gargiulo Isacco

submission deadline 31 Jan 2026 | Viewed by 213 | Submission Open

Keywords: dental pulp stem cells; cell injections; modified cells; cell sheets; cell spheroids; regeneration; damaged tissues; immunomodulation

(This special issue belongs to the Section Regenerative Engineering)

New Sights of Machine Learning and Digital Models in Biomedicine

edited by Hatem Alhadainy

submission deadline 31 Jan 2026 | Viewed by 212 | Submission Open

Keywords: machine learning; biomedical imaging; predictive modeling; medical data analytics; genomics; precision medicine; bioinformatics; machine learning algorithms; computer-aided diagnosis; imaging analysis; clinical decision support; electronic health records (EHR); disease prediction simulation models; virtual patients; drug discovery; health informatics

(This special issue belongs to the Section Biosignal Processing)

Robotics and Virtual Reality for Rehabilitation

edited by

Marcos José Navarro-Santana

submission deadline 31 Jan 2026 | Viewed by 207 | Submission Open

Keywords: rehabilitation technology; wearable robotics; telerehabilitation; virtual reality; artificial intelligence; personalized therapy

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advances in Biomolecular Engineering for Regenerative Therapeutics

edited by

Christopher Robinson

and Paul Jordan Christo

submission deadline 31 Jan 2026 | Viewed by 173 | Submission Open

Keywords: regenerative medicine; growth factors; gene therapy; exosomes; extracellular vesicles; proteomics; genomics; CRISPR; stem cells

(This special issue belongs to the Section Regenerative Engineering)

Advanced Data Processing for Wearable Neurophysiological Monitoring in Real-World Settings

edited by

Vincenzo Ronca

and

Pietro Aricò

submission deadline 31 Jan 2026 | Viewed by 152 | Submission Open

Keywords: wearable neurophysiological signals; artifact removal; real-world monitoring; machine learning for biosignals; human factors; bioinformatics; bioengineering

(This special issue belongs to the Section Biosignal Processing)

Targeting Biofilm-Associated Infections: Mechanistic Insights, Challenges, and Therapeutic Innovations

edited by

Zhaojun Jia

and Jianglong Yan

submission deadline 31 Jan 2026 | Viewed by 133 | Submission Open

Keywords: biofilm formation; antimicrobial resistance; biofilm disruption; bacterial infections; biomedical device-associated infections (BAIs); immunomodulatory biomaterials; antibacterial materials; antibacterial surface modification; photocatalytic disinfection; sonodynamic antibacterial therapy

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Biofabrication Technologies: Novel Tools for More Effective Personalized Medicine and Regenerative Therapies

edited by

Giovanni Vozzi

Paola Nieri

and Mauro Di Stasi

submission deadline 31 Jan 2026 | Viewed by 112 | Submission Open

Keywords: biodegradable polymers; biocompatible polymers; biomedical applications; biomaterials; renewable biomaterials; tissue engineering; regenerative medicine; biofabrication and bioprinting; personalized medicine; 3D tissue models

(This special issue belongs to the Section Regenerative Engineering)

Advances in Polyhydroxyalkanoate (PHA) Production, 5th Edition

edited by

Martin Koller

submission deadline 31 Jan 2026 | Viewed by 110 | Submission Open

Keywords: polyhydroxyalkanoate (PHA); biopolyesters; bioprocess design; sustainable development

(This special issue belongs to the Section Biochemical Engineering)

Cardiac Digital Twins and AI: From Multi-Modal Modeling to Medical Implementation

edited by Lei Li,

Rodrigo Weber Dos Santos

and Julia Camps

submission deadline 31 Jan 2026 | Viewed by 76 | Submission Open

Keywords: cardiac digital twins; multi-modal modeling; AI in cardiology; clinical translation; multi-modal data integration; personalized cardiac modeling; real-time simulation; cardiovascular precision medicine

(This special issue belongs to the Section Biosignal Processing)

MRI Techniques for Disease Detection

edited by Christine Fernandez-Maloigne

submission deadline 31 Jan 2026 | Viewed by 73 | Submission Open

Keywords: MRI; disease detection; artificial intelligence; deep learning

(This special issue belongs to the Section Biosignal Processing)

Dental Biomaterials: Current and Future Perspectives

edited by Sandro Basso Bitencourt,

Emily Vivianne Freitas da Silva

and Natalia Bastos-Bitencourt

submission deadline 31 Jan 2026 | Viewed by 71 | Submission Open

Keywords: dental materials; 3D printing; ceramics; CAD/CAM; bioactivity

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Neuro-Bioengineering Innovations: Integrative Approaches for Diagnostics, Implants and Regenerative Therapies

edited by Frank D. Vrionis,

Maohua Lin

, Yufei Tang and Mohsen Ahmadi

submission deadline 31 Jan 2026 | Viewed by 70 | Submission Open

Keywords: machine learning; artificial intelligence; spinal cord; neural interface technologies; implantable micro-devices; neuroimaging; explainable AI; finite element modeling; physics-informed neural networks (PINNs); bioinformatics; smart sensors; muscle modeling; biomechanics

(This special issue belongs to the Section Biosignal Processing)

Advancements in Drug Design and Delivery for Neuropsychological Disorders: Integrating Bioinformatics and Nanotechnology

edited by

Tahmineh Mokhtari

submission deadline 31 Jan 2026 | Viewed by 61 | Submission Open

Keywords: neuropsychological disorders; drug design; drug delivery; bioinformatics; nanotechnology; computational drug design; targeted therapies; neuropharmacology; nanomedicine; bioengineering

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Intelligent Healthcare and Auditory Health: Machine Learning-Based Multimodal Biomedical Data Mining for Diagnosis

edited by

Meihong Wu

and

Yunfeng Wu

submission deadline 31 Jan 2026 | Viewed by 56 | Submission Open

Keywords: computer-aided diagnosis; speech signal processing; auditory information processing; neurodegenerative diseases; wearable devices; health informatics; multimodal fusion; telemedicine; rehabilitation engineering; noise-robust algorithms; acoustic feature extraction; cognitive impairment screening; end-to-end speech enhancement

(This special issue belongs to the Section Biosignal Processing)

Recent Advances in Cardiothoracic Assist Devices

edited by Suvitesh Luthra and

Enrique Berjano

submission deadline 31 Jan 2026 | Viewed by 55 | Submission Open

Keywords: mechanical circulatory support; VAD; OCS; LBE and EVLP; total artificial heart; heart failure; maglev and axial flow pumps; minimally invasive; wireless power; biocompatibility; AI in cardiac devices

(This special issue belongs to the Section Regenerative Engineering)

Technologies for the Regeneration of Bone Tissue

edited by

Yvonne Reinwald