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Bioengineering publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Wearable Device for Musculoskeletal Disease

edited by Ye(Julie) Li

submission deadline 31 Jul 2025 | Viewed by 84 | Submission Open

Keywords: wearable devices; musculoskeletal diseases; biomechanical sensors; remote rehabilitation; real-time monitoring; injury prediction and prevention

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Digital Technologies to Improve Diagnostic Cytopathology: Future Outlook

edited by

Enrico Giarnieri

submission deadline 31 Jul 2025 | Viewed by 76 | Submission Open

Keywords: machine learning; cytopathology; digital cytology; computer-aided diagnosis; virtual reality; natural language process

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Deep Learning in Medical Applications: Challenges and Opportunities

edited by Richard Bayford

submission deadline 31 Jul 2025 | Viewed by 66 | Submission Open

Keywords: deep learning; medical imaging; healthcare; artificial intelligence

(This special issue belongs to the Section Biosignal Processing)

Advanced Data Processing for Wearable Neurophysiological Monitoring in Real-World Settings

edited by

Vincenzo Ronca

and

Pietro Aricò

submission deadline 31 Jul 2025 | Viewed by 66 | Submission Open

Keywords: wearable neurophysiological signals; artifact removal; real-world monitoring; machine learning for biosignals; human factors; bioinformatics; bioengineering

(This special issue belongs to the Section Biosignal Processing)

Engineering Microalgal Systems for a Greener Future

edited by

Ana F. Esteves

and

Alok Kumar Patel

submission deadline 20 Aug 2025 | 1 articles | Viewed by 824 | Submission Open

Keywords: artificial intelligence; machine learning; bioprocessing; circular bioeconomy; production value addition; biomass valorization; microalgal cultivation systems; sustainable bioprocessing

(This special issue belongs to the Section Biochemical Engineering)

Current Trends in Robotic Rehabilitation Technology

edited by Serena Filoni,

Raffaello Pellegrino

and

Eduardo Palermo

submission deadline 25 Aug 2025 | Viewed by 742 | Submission Open

Keywords: rehabilitation robotics; machine learning and artificial intelligence; neurological diseases; neuroplasticity; virtual reality for rehabilitation

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Bioengineering Platforms for Drug Delivery

edited by Anam Ahsan

submission deadline 25 Aug 2025 | Viewed by 287 | Submission Open

Keywords: biomaterials; drug delivery; nanotechnology; nanobiotechnology; bioengineering platforms; targeted drug delivery; chemotherapy; bioconjugation; disease management; therapeutic agents

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Stem Cell Bioprocessing

edited by Mariana Petronela Hanga and Eirini Theodosiou

submission deadline 25 Aug 2025 | Viewed by 275 | Submission Open

Keywords: bioprocessing of stem cells; microcarriers; biomaterials; stem cell therapy; cultivated meat; ATMPs; extracellular vesicles

(This special issue belongs to the Section Regenerative Engineering)

Mathematical Models for Medical Diagnosis and Testing

edited by

Peiyuan Zhou

and

Andrew K. C. Wong

submission deadline 30 Aug 2025 | 1 articles | Viewed by 578 | Submission Open

Keywords: mathematical modeling; machine learning; artificial intelligence; pattern discovery; medical diagnosis; clinical data analysis; predictive analytics; explainable AI; statistical modeling; anomaly detection; rare disease detection; knowledge discovery; health informatics

(This special issue belongs to the Section Biosignal Processing)

Wearable Sensors and Measurement Systems for Human Physiology Monitoring

edited by

Manob Saikia

submission deadline 31 Aug 2025 | 9 articles | Viewed by 21815 | Submission Open

Keywords: wearable sensor; measurement system; bioinstrumentation; wearable neuroimaging; flexible biosensors; bioelectronics; Internet of Things in healthcare; prototyping; signal processing; physiological measurement; parameters; injury prevention; rehabilitation; wellness monitoring; chronic disease

(This special issue belongs to the Section Biosignal Processing)

Artificial Intelligence for Computer-Aided Detection in Biomedical Applications

edited by

Lawrence Chan

submission deadline 31 Aug 2025 | 9 articles | Viewed by 17743 | Submission Open

Keywords: artificial intelligence; computer-aided detection; CAD; biomedical applications; biomedical engineering; radiology; medical imaging; bioinformatics; deep learning; machine learning; disease diagnosis

(This special issue belongs to the Section Biosignal Processing)

AI-Powered Diagnosis and Treatment Plans in Dentistry and Orofacial Fields

edited by

Antonino Lo Giudice

, Rosalia Leonardi,

Victor Díaz-Flores García

and

Yolanda Freire

submission deadline 31 Aug 2025 | 11 articles | Viewed by 15851 | Submission Open

Keywords: artificial intelligence; AI; digital dentistry; digital systems; CBCT; CAD-CAM

(This special issue belongs to the Section Biosignal Processing)

Mathematical and Computational Modeling of Cancer Progression

edited by

Leili Shahriyari

and

Pasquale De Luca

submission deadline 31 Aug 2025 | 6 articles | Viewed by 12541 | Submission Open

Keywords: computational oncology; cancer progression; cancer treatments; mechanistic modeling of cancer; integration of machine learning and mechanistic modeling

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advances in Thermal Therapy

edited by Aili Zhang and Kai Yue

submission deadline 31 Aug 2025 | 7 articles | Viewed by 11276 | Submission Open

Keywords: thermal treatments; thermal ablation; hyperthermia; cryosurgery; thermally enhanced treatment

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Inspired by Nature: Advanced Biomaterials and Manufacturing Solutions for Skeletal Tissue Regeneration and Osteoarthritis Treatment

edited by

Elena A. Jones

submission deadline 31 Aug 2025 | 4 articles | Viewed by 11183 | Submission Open

Keywords: bone and cartilage regeneration; osteoarthritis; immunomodulatory and infection-control biomaterials; bioactive matrices; microspheres; nanoparticles; bioinks; biomimetics; delivery methods

(This special issue belongs to the Section Regenerative Engineering)

Fabrication of Biomaterials to Develop Tissue Engineering Scaffolds and Medical Devices

edited by

Iruthaya Pandi Selestin Raja

submission deadline 31 Aug 2025 | 2 articles | Viewed by 5593 | Submission Open

Keywords: tissue engineering; biocompatible polymers; nanomaterials; biofabrication; bioprinting; photobiomodulation patches; smart medical devices; cell– biomaterial interaction

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Applications of Genomic Technology in Disease Outcome Prediction

edited by

Sulev Koks

submission deadline 31 Aug 2025 | 3 articles | Viewed by 4805 | Submission Open

Keywords: genomic technology; disease outcome prediction; genetic analysis; genetic variations; genome-wide association studies (GWAS); genetic risk factors; biomarkers; genetic risk score; next-generation sequencing (NGS); rare genetic variants; personalized medicine; treatment strategies.

(This special issue belongs to the Section Cellular and Molecular Bioengineering)

Cardiovascular Hemodynamic Characterization: Prospects and Challenges

edited by

and

submission deadline 31 Aug 2025 | 2 articles | Viewed by 3543 | Submission Open

Keywords: cardiovascular system; biofluid mechanics; hemodynamics; in-silico modeling; computational fluid dynamics; in-vitro modeling; flow visualization and tracking

New Sights of EEG and Brain Diseases: Updates and Directions

edited by

Carlos Trenado

and Christian Penaloza

submission deadline 31 Aug 2025 | 3 articles | Viewed by 3383 | Submission Open

Keywords: EEG; brain diseases; neuropsychiatric conditions; prosthetics

(This special issue belongs to the Section Biosignal Processing)

Microfluidics and Sensor Technologies in Biomedical Engineering

edited by Ali Asgar Bhagat

submission deadline 31 Aug 2025 | 3 articles | Viewed by 3236 | Submission Open

Keywords: lab-on-a-chip; microfluidics fabrication; MEMS; point-of-care diagnostics; biosensors; materials

(This special issue belongs to the Section Biosignal Processing)

Engineered Analysis of Tissue Mechanics and Blood Flow for Cardiovascular Host-Device Interaction

edited by Karen May-Newman

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2607 | Submission Open

Keywords: solid– fluid mechanics; stress; strain; shear; flow; thrombus formation; hemocompatibility; medical device

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Ultrasound Elastography in Biomedicine: Principles, Techniques and Applications

edited by Abbas Samani

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2353 | Submission Open

Keywords: ultrasound elastography; motion tracking; inverse problems; quasi-static elastography; strain imaging; stiffness imaging; dynamic elastography; shear wave elastography; transient elastography; instrumentation; clinical applications

(This special issue belongs to the Section Biosignal Processing)

New Sights of Deep Learning and Biomedical Image Processing: Updates, Applications, and Directions

edited by Yuxuan Cheng and Lin Shan

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2332 | Submission Open

Keywords: deep learning; biomedical imaging; optical coherence tomography; microscopy; X-ray; CT; MRI; ultrasound; endoscopy; laparoscopy; cystoscopy; image classification; image segmentation; biomarker detection; image registration; multimodal medical imaging

(This special issue belongs to the Section Biosignal Processing)

Computational Biofluid Dynamics

edited by

Tinghui Zheng

Peng Wu

and Jun Wen

submission deadline 31 Aug 2025 | 4 articles | Viewed by 2129 | Submission Open

Keywords: biofluids; cardiovascular and pulmonary systems; machine learning; critical care

(This special issue belongs to the Section Biosignal Processing)

Application of Artificial Intelligence in Complex Diseases

edited by Yan Zhu

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1933 | Submission Open

Keywords: artificial intelligence; machine learning; complex diseases; healthcare; diagnostics; predictive modeling; medical imaging; ethics in AI

(This special issue belongs to the Section Biosignal Processing)

Recent Advances in Genomics Research

edited by Chien-Wei (Masaki) Lin

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1260 | Submission Open

Keywords: genomics data analysis; NGS; AI; machine learning; multi-omics integration; single-cell sequencing; precision medicine

(This special issue belongs to the Section Cellular and Molecular Bioengineering)

Biomechanics and Mechanobiology in Cell and Tissue Engineering

edited by

Aaron Baker

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1203 | Submission Open

Keywords: biomechanics; mechanobiology; tissue engineering; cell engineering; vascular; cardiovascular; neuroengineering; stem cells; cancer; osteoarthritis; bone

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Recent Advances in Cancer Bioinformatics

edited by

Pritam Kumar Panda

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1161 | Submission Open

Keywords: cancer bioinformatics; computational modeling; cancer biophysics; single-cell sequencing; whole exome sequencing (WES); whole genome sequencing (WGS); RNA sequencing (RNA-seq); tumor heterogeneity; cancer genomics; personalized medicine; predictive modeling; cancer pathways; oncogenesis; tumor microenvironment; bioinformatics tools; omics integration

(This special issue belongs to the Section Biosignal Processing)

Advancing Treatment for Brain Tumors

edited by

Min D. Tang-Schomer

and Joanna J. Gell

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1091 | Submission Open

Keywords: brain tumor model; tumor microenvironment; brain microenvironment; personalized medicine; xenograft model; molecular profiling; glioblastoma; ependymoma; medulloblastoma; astrocytoma; pediatric brain tumor

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Multiclass Prediction and Assisted Diagnosis of Mental Disorders Based on Eye Movement and Other Physiological Signals

edited by Quan Wang

submission deadline 31 Aug 2025 | 1 articles | Viewed by 613 | Submission Open

Keywords: physiological signals; mental disorders; eye movement

(This special issue belongs to the Section Biosignal Processing)

Machine Learning and Artificial Intelligence in Pediatric Healthcare

edited by

Hammad Ashraf Ganatra

submission deadline 31 Aug 2025 | Viewed by 610 | Submission Open

Keywords: artificial intelligence; machine learning; pediatrics; natural language processing; diagnostics

(This special issue belongs to the Section Biosignal Processing)

Advances and Innovations in Wound Repair and Regeneration

edited by

Shiva Akbarzadeh

submission deadline 31 Aug 2025 | Viewed by 537 | Submission Open

Keywords: engineered skin graft; three-dimensional skin printing; skin grafting in animal models; dermal substitutes

(This special issue belongs to the Section Regenerative Engineering)

The Next Generation of Tissue Engineering

edited by Tetsuya Imamura

submission deadline 31 Aug 2025 | 1 articles | Viewed by 478 | Submission Open

Keywords: tissue engineering; mesenchymal stem cells; engineered cell sheets; biofabricated cell structures

(This special issue belongs to the Section Regenerative Engineering)

Surrogate Biomedical Data Generation

edited by

Saeid Sanei

and Tracey KM Lee

submission deadline 31 Aug 2025 | Viewed by 395 | Submission Open

Keywords: surrogate; augmentation; deep learning; machine learning; biomedical images; biomedical signals; edge systems; testing

(This special issue belongs to the Section Biosignal Processing)

Transforming Regenerative Medicine: Innovations in Bioengineered Extracellular Vesicles

edited by

Byeong-Cheol Ahn

and

Prakash Gangadaran

submission deadline 31 Aug 2025 | Viewed by 373 | Submission Open

Keywords: extracellular vesicles (EVs); targeted drug delivery; chemical modification; genetic modification; ligand attachment; click chemistry; multifunctional peptides; hybrid exosome-liposome; bioengineering; regenerative medicine; therapeutic applications; biomanufacturing

(This special issue belongs to the Section Regenerative Engineering)

IoT Technology in Bioengineering Applications: Second Edition

edited by Mihaela Hnatiuc and Larbi Boubchir

submission deadline 31 Aug 2025 | Viewed by 329 | Submission Open

Keywords: robotic device; signal processing; image processing; communication protocol; embedded system; smart sensors; cloud/FOG; predictive methods; monitoring; process optimization; diagnosis; implant; tele surgery; teleconsultation; telemonitoring

(This special issue belongs to the Section Biosignal Processing)

Extended Reality Technologies, Medical Robotics Solutions, and Deep Learning in Translational Medicine—2nd Edition

edited by

Fabrizio Cutolo

submission deadline 31 Aug 2025 | Viewed by 224 | Submission Open

Keywords: extended reality interfaces for surgical navigation and surgical training; extended reality interfaces for translational medicine; computer vision solutions for healthcare; smart sensors for image-guided surgery; visual and multimodal tracking algorithms in translational medicine; wearable-friendly human-computer interaction solutions in healthcare

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Recent Trends and Future Directions in Biosignal Processing and Applications: State-of-the-Art Reviews

edited by

Andrea Cataldo

and Raissa Schiavoni

submission deadline 31 Aug 2025 | Viewed by 212 | Submission Open

Keywords: biosignal processing; biomedical engineering healthcare; biosignals; signal processing; data analysis; biomedical imaging; biosensors; wearable sensors; artificial intelligence (AI); machine learning (ML); predictive modeling; personalized medicine; early disease detection

(This special issue belongs to the Section Biosignal Processing)

New Sights of Image Processing and Digital Models in Biomedicine

edited by Seyed Jalalddelin Mousavirad and

Diego Oliva

submission deadline 31 Aug 2025 | Viewed by 209 | Submission Open

Keywords: image processing and computer vision; deep learning; artificial intelligence; biomedicine

(This special issue belongs to the Section Biosignal Processing)

Innovative Approaches: Harnessing Virtual Reality for Assessment and Rehabilitation in Stroke and Aging-Related Disorders

edited by Gauthier Everard and

Charles Sebiyo Batcho

submission deadline 31 Aug 2025 | Viewed by 186 | Submission Open

Keywords: virtual reality; assessment; rehabilitation; stroke; neurorehabilitation; older adults; kinematics; cognition

(This special issue belongs to the Section Biosignal Processing)

The Encapsulation of Bioactive Molecules: The Current and Future Potential for Biotechnology Applications

edited by

Edward Weaver

submission deadline 31 Aug 2025 | Viewed by 162 | Submission Open

Keywords: encapsulation; delivery system; targeted delivery; bioactive molecule; viral vector

(This special issue belongs to the Section Biochemical Engineering)

New Sight of Deep Learning in Bioengineering: Updates and Future Directions (2nd Edition)

edited by

Tao Zhang

submission deadline 31 Aug 2025 | Viewed by 154 | Submission Open

Keywords: deep learning; biomedicine; robotics and biomechanics; biomedical imaging; biosignal processing

(This special issue belongs to the Section Biosignal Processing)

Advancements in Human–Machine Interaction and Robotics: From Biomechanics to Cognitive Neuroscience

edited by Jiejunyi Liang

submission deadline 31 Aug 2025 | Viewed by 148 | Submission Open

Keywords: human-machine interaction; robotics; biomechanics; cognitive neuroscience; anthropomorphic robotic systems

Augmented Reality, Virtual Reality and Extended Reality Solutions for Biomedical Applications

edited by

Vera Gramigna

and Arrigo Palumbo

submission deadline 31 Aug 2025 | Viewed by 132 | Submission Open

Keywords: augmented reality (AR); virtual reality (VR); extended reality (XR); biomedicine; human– robot interaction; technology in healthcare; medical imaging; surgical simulation; surgical navigation; robotic-assisted surgery; rehabilitation technology; neurological disorders’ treatment; pain management; personalized healthcare; artificial intelligence (AI) in medicine; human– computer interaction in healthcare; digital health technologies

(This special issue belongs to the Section Biosignal Processing)

Bio-Scaffold Engineering for Soft Tissue Regenerative Medicine

edited by Zhonggang Feng

submission deadline 31 Aug 2025 | Viewed by 124 | Submission Open

Keywords: bio-scaffold engineering; decellularization; 3D bio-printing; hydrogel; polymer; natural materials; electrospinning; mechanical environment; cellular homeostasis; simulation

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Microfluidic Platform for Bioengineering and Translational Research

edited by

Sudip K. Das

submission deadline 31 Aug 2025 | Viewed by 116 | Submission Open

Keywords: microfluidic devices; biosensors; disease diagnosis; organ-on-chip platforms; drug discovery; tissue engineering

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

New Trends in Biomechanical Modeling in Musculoskeletal Disorders and Diseases

edited by

Philippe Gorce

submission deadline 31 Aug 2025 | Viewed by 113 | Submission Open

Keywords: musculoskeletal disorders; musculoskeletal diseases; injury biomechanics; muscle biomechanics dynamic and kinematic modeling; gait and posture; muscle electromyography; motion analysis; postural control and balance; occupational health; occupational ergonomics; sport medicine; sport performance; quality of life

(This special issue belongs to the Section Biomechanics and Sports Medicine)

Computational Intelligence for Healthcare

edited by

Jiaojiao Wang

, Chee Wei Tan and Qingpeng Zhang

submission deadline 31 Aug 2025 | Viewed by 100 | Submission Open

Keywords: artificial intelligence; big data analytics; generative models; pathogen tracking and tracing; chronic disease prediction and management; predictive modeling; bioinformatics; pandemic preparedness; IoT-enabled biosensors; health disparities and ethics; multi-modal data fusion

(This special issue belongs to the Section Biosignal Processing)

Tendon/Ligament and Enthesis Injuries: Repair and Regeneration

edited by Dai Fei Elmer Ker, Jingyu Shi and Bingyang Dai

submission deadline 31 Aug 2025 | Viewed by 99 | Submission Open

Keywords: tendon; ligament; enthesis; drug delivery; therapeutics; biomaterials; tissue engineering; musculoskeletal animal models

(This special issue belongs to the Section Regenerative Engineering)

Advancing Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Through Computer-Aided Drug Design

edited by