Nerve Regeneration

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 515

Special Issue Editors


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Guest Editor
Istituto Zooprofilattico Sperimentale della Sicilia, Palermo, Italy
Interests: regenerative surgery; tissue imaging; laparoscopic surgery; nerve regeneration

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Guest Editor
Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Human Anatomy, “Sapienza” University of Rome, Via A. Borelli 50, 00161 Rome, Italy
Interests: cell death; autophagy; cancer growth; organ homeostasis; tissue regeneration
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Guest Editor
Department of Molecular and Translational Medicine, Center of Emphasis in Diabetes and Metabolism, Texas Tech University Health Sciences Center, 5001 El Paso Drive, El Paso, TX 79905, USA
Interests: tissue engineering; inflammation; nerve regeneration; stem cells; gene therapy; cardiac tissue
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nerve regeneration is a critical process involving the repair and restoration of damaged nerves, which is essential for functional recovery in patients with traumatic nerve injuries, neurodegenerative diseases, and other neurological disorders. As a complex and intricate biological process, nerve regeneration presents significant challenges in terms of understanding the underlying mechanisms, developing effective therapeutic strategies, and achieving successful clinical outcomes.

This Special Issue aims to provide a platform for researchers, clinicians, and experts in the field of bioengineering to share the latest advances, cutting-edge technologies, and innovative approaches in nerve regeneration research. Topics of interest include, but are not limited to, nerve tissue engineering, biomaterials for nerve repair, stem cell-based therapies, nerve guidance conduits, neuroprosthetics, and bioelectronic medicine.

By bringing together multidisciplinary perspectives and collaborative efforts, this Special Issue seeks to advance our knowledge and capabilities in promoting nerve regeneration and improving the quality of life for patients with neurological disorders. We invite researchers to contribute original research articles, reviews, and perspectives that address the challenges and opportunities in nerve regeneration, with the ultimate goal of translating scientific discoveries into clinical applications.

Dr. Luca Cicero
Dr. Claudia Giampietri
Dr. Munmun Chattopadhyay
Guest Editors

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Keywords

  • nerve regeneration
  • neuroengineering
  • biomaterials
  • stem cells
  • neuroprosthetics
  • biomedical devices

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Published Papers (1 paper)

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Research

14 pages, 1327 KiB  
Article
Exploration of Cytokines That Impact the Therapeutic Efficacy of Mesenchymal Stem Cells in Alzheimer’s Disease
by Herui Wang, Chonglin Zhong, Yi Mi, Guo Li, Chenliang Zhang, Yaoyao Chen, Xin Li, Yongjun Liu and Guangyang Liu
Bioengineering 2025, 12(6), 646; https://doi.org/10.3390/bioengineering12060646 - 12 Jun 2025
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Abstract
Current therapies for Alzheimer’s disease (AD) includes acetylcholinesterase inhibitors, NMDA receptor antagonists, and amyloid beta (Aβ)/Tau-targeting drugs. While these drugs improve cognitive decline and target the pathological mechanisms, their outcomes still are still in debate. Mesenchymal stem cells (MSCs) offer a regenerative approach [...] Read more.
Current therapies for Alzheimer’s disease (AD) includes acetylcholinesterase inhibitors, NMDA receptor antagonists, and amyloid beta (Aβ)/Tau-targeting drugs. While these drugs improve cognitive decline and target the pathological mechanisms, their outcomes still are still in debate. Mesenchymal stem cells (MSCs) offer a regenerative approach by modulating neuroinflammation and promoting neuroprotection. Although the paracrine of MSCs is efficient in various AD preclinical studies and the exosomes of MSCs have entered clinical trials, the key cytokines driving the efficacy remain unclear. Here, we evaluated human umbilical cord-derived MSCs (hUC-MSCs) and employed gene-silenced MSCs (siHGF-MSCs, siTNFR1-MSCs, siBDNF-MSCs) in APP/PS1 AD mice to investigate specific mechanisms. hUC-MSCs significantly reduced Aβ/Tau pathology and neuroinflammation, with cytokine-specific contributions: silencing HGF predominantly reduced Aβ/Tau clearance, although silencing TNFR1 or BDNF showed modest effects; silencing TNFR1 or BDNF more prominently weakened anti-neuroinflammation, while silencing HGF exerted a weaker influence. All three cytokines partially contributed to oxidative stress reduction and cognitive improvements. Our study highlights MSC-driven AD alleviation as a multifactorial strategy and reveals specific cytokines alleviating different aspects of AD pathology. Full article
(This article belongs to the Special Issue Nerve Regeneration)
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