Advancements in Bioreactors for Tissue Engineering
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".
Deadline for manuscript submissions: 1 December 2025 | Viewed by 81
Special Issue Editors
Interests: anticancer drug
Interests: bioengineering; biomedical engineering; tissue engineering; microfabrication; bioreactors for tissue culture; microactuators fabrication
Special Issues, Collections and Topics in MDPI journals
Interests: bioprocess engineering; fermentation; biocatalysis; metabolic engineering; stem cell and tissue engineering; microfluidic bioreactors and biochips for high throughput screening and biodiagnostics
Special Issue Information
Dear Colleagues,
Tissue engineering is at a pivotal moment, with bioreactors at the heart of its evolution. As the demand for functional, implantable tissues grows, so does the need for advanced bioreactor technologies capable of mimicking the complexity of the human body. In recent years, the field has seen a surge in innovative bioreactor systems that integrate perfusion, mechanical stimulation, biochemical gradients, and real-time monitoring—bringing engineered tissues closer than ever to clinical translation.
This Special Issue, Advancements in Bioreactors for Tissue Engineering, aims at bringing together the latest breakthroughs in bioreactor design and application. We invite contributions that push the boundaries of how bioreactors cultivate complex tissues, including skin, cardiac, vascular, liver, cartilage, bone, lung, and prostate. We are particularly interested in emerging frontiers bridging the gap between traditional tissue engineering and regenerative medicine.
Yet, despite these advancements, major hurdles remain. How can we ensure scalable and reproducible tissue production? How do we integrate real-time, non-destructive monitoring to assess tissue quality and function? Can we harness computational fluid modeling to dynamically adapt bioreactor conditions to evolving tissue needs? Addressing these challenges is crucial for transitioning engineered tissues from the lab to the clinic.
This Special Issue invites researchers from bioengineering, bioprocessing, and regenerative medicine to share their cutting-edge work and bold ideas. We seek original research articles and comprehensive reviews that explore the following topics:
- Innovative bioreactor designs for scalable tissue production;
- Advanced perfusion and mechanical stimulation strategies to enhance tissue maturation;
- Real-time monitoring and sensing technologies for assessing tissue functionality;
- Integration of bioprocess principles into tissue engineering workflows;
- Computational modeling approaches to optimize bioreactor performance;
- In vivo bioreactors as next-generation strategies for tissue development.
By bringing together pioneering research, this Special Issue aims at accelerating the development of bioreactor technologies that will shape the future of tissue engineering. Join us in driving innovation and bringing engineered tissues closer to real-world applications!
We look forward to your contributions.
Dr. Emma Petiot
Prof. Dr. Giovanni Vozzi
Prof. Dr. Shang-Tian Yang
Guest Editors
Dr. Mikhael Hadida
Dr. Mauro Di Stasi
Guest Editor Assistants
Manuscript Submission Information
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Keywords
- tissue engineering
- perfusion bioreactors
- bioprocessing
- mechanical stimulation
- fluid shear stress
- oxygen regulation
- real-time monitoring
- scalable tissue production
- computational modeling
- smart bioreactors
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