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Bioengineering
Special Issues
Tissue Engineering and Regenerative Medicine Strategies for Biomedical Engineering
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Tissue Engineering and Regenerative Medicine Strategies for Biomedical Engineering

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 733

Special Issue Editors

Dr. Hun Jin Jeong

E-Mail Website
Guest Editor
Columbia University Irving Medical Center, New York, NY, USA
Interests: tissue engineering; 3D bioprinting; mechanobiology; biofabrication; microfluidics
Dr. Solaiman Tarafder

E-Mail Website
Guest Editor
Department of Mechanical Engineering, South Dakota State University, Brookings, SD 57007, USA
Interests: biomaterials; tissue engineering; cartilage; meniscus; tendon
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The fields of tissue engineering and regenerative medicine are gaining considerable attention as promising areas, not only for creating three-dimensional engineered tissues for the reconstruction of damaged tissues but also for investigating the complex physiological interactions between tissues through various strategies, such as 3D bioprinting, microfluidic devices, and bioactive molecules. Furthermore, the recent success of mRNA vaccines in clinical applications has inspired discussions on new, promising approaches in regenerative medicine.

In this Special Issue, we aim to present recent comprehensive research in the fields of regenerative medicine and tissue engineering, encompassing areas such as 3D printing, microfluidic devices, and targeted biomolecular delivery systems. But this Issue is not limited to these topics alone. Additionally, we welcome a comprehensive review article that summarizes the strategies for regenerative medicine in specific disorders affecting large populations worldwide, as this will provide valuable insights. Both original research articles and reviews are encouraged, and all submissions will undergo a peer-review process and be published in an open-access format.

Dr. Hun Jin Jeong
Dr. Solaiman Tarafder
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • regenerative medicine
  • bioprinting
  • microfluidics
  • tissues on chip

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Published Papers (2 papers)

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Review

18 pages, 1011 KiB  
Review
Assessing Implantation Sites for Pancreatic Islet Cell Transplantation: Implications for Type 1 Diabetes Mellitus Treatment
by Vinícius Gabriel Silvério Scholl, Leonardo Todeschini Justus, Otávio Simões Girotto, Kelly Karine Pasqual, Matheus Henrique Herminio Garcia, Fernando Gonçalves da Silva Petronio, Aline Flores de Moraes, Sandra Maria Barbalho, Adriano Cressoni Araújo, Lucas Fornari Laurindo, Cristina Pires Camargo and Maria Angélica Miglino
Bioengineering 2025, 12(5), 499; https://doi.org/10.3390/bioengineering12050499 - 9 May 2025
Viewed by 322
Abstract
Type 1 diabetes mellitus (T1DM) involves the destruction of pancreatic β-cells, requiring ongoing insulin therapy. A promising alternative for management is pancreatic islet transplantation, or the bioartificial pancreas. Here, we examine the primary implantation sites for the bioartificial pancreas, highlighting their anatomical, physical, [...] Read more.
Type 1 diabetes mellitus (T1DM) involves the destruction of pancreatic β-cells, requiring ongoing insulin therapy. A promising alternative for management is pancreatic islet transplantation, or the bioartificial pancreas. Here, we examine the primary implantation sites for the bioartificial pancreas, highlighting their anatomical, physical, and immunological characteristics in the context of T1DM treatment. Traditionally used for islet transplantation, the liver promotes metabolic efficiency due to portal drainage; however, it presents issues such as hypoxia and inflammatory responses. The omentum offers excellent vascularization but has limited capacity for subsequent transplants. The renal subcapsular space is advantageous when combined with kidney transplants; however, its use is limited due to low vascularization. The subcutaneous space is notable for its accessibility and lower invasiveness, although its poor vascularization poses significant challenges. These challenges can be mitigated with bioengineering strategies. The gastrointestinal submucosa provides easy access and good vascularization, which makes it a promising option for endoscopic approaches. Additionally, the intrapleural space, which remains underexplored, offers benefits such as increased oxygenation and reduced inflammatory response. Selecting the ideal site for bioartificial pancreas implantation should balance graft support, complication reduction, and surgical accessibility. Bioengineered devices and scaffolds can address the limitations of traditional sites and enhance T1DM management. Full article
(This article belongs to the Special Issue Tissue Engineering and Regenerative Medicine Strategies for Biomedical Engineering)
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28 pages, 3184 KiB  
Review
Bioengineered Approaches for Esophageal Regeneration: Advancing Esophageal Cancer Therapy
by Jae-Seok Kim, Hyoryung Nam, Eun Chae Kim, Hun-Jin Jeong and Seung-Jae Lee
Bioengineering 2025, 12(5), 479; https://doi.org/10.3390/bioengineering12050479 - 30 Apr 2025
Viewed by 170
Abstract
Esophageal cancer (EC) is the eighth leading cause of cancer-related deaths globally, largely due to its late-stage diagnosis and aggressive progression. Esophagectomy remains the primary treatment, typically requiring organ-based reconstruction techniques such as gastric pull-up or colonic interposition. However, these reconstruction methods often [...] Read more.
Esophageal cancer (EC) is the eighth leading cause of cancer-related deaths globally, largely due to its late-stage diagnosis and aggressive progression. Esophagectomy remains the primary treatment, typically requiring organ-based reconstruction techniques such as gastric pull-up or colonic interposition. However, these reconstruction methods often lead to severe complications, significantly reducing the quality of life of patients. To address these limitations, tissue engineering has emerged as a promising alternative, offering bioengineered patch-type and tubular-type scaffolds designed to restore both structural integrity and functional regeneration. Recent advancements in three-dimensional (3D) biofabrication—including 3D bioprinting, electrospinning, and other cutting-edge techniques—have facilitated the development of patient-specific constructs with improved biocompatibility. Despite significant advancements, critical challenges persist in achieving mechanical durability, multilayered cellular organization, and physiological resilience post-transplantation. Ongoing research continues to address these limitations and enhance clinical applicability. Therefore, this review aims to examine recent advancements in esophageal tissue engineering, with a focus on key biofabrication techniques, preclinical animal models, and the major translational challenges that must be addressed for successful clinical application. Full article
(This article belongs to the Special Issue Tissue Engineering and Regenerative Medicine Strategies for Biomedical Engineering)
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