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Bioengineering publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Technological Advances for Gait and Balance Assessment

edited by Alessandro Zampogna,

Silvia Del Din

and

Florenc Demrozi

submission deadline 31 Jan 2026 | 5 articles | Viewed by 10956 | Submission Open

Keywords: novel diagnostic devices and wearable sensors; machine learning and artificial intelligence applications; biomechanical analysis; telemedicine and remote monitoring solutions

(This special issue belongs to the Section Biosignal Processing)

Advanced Technology for Implant Polymers in Orthopaedics, Spine, and Trauma

edited by Steven M. Kurtz, Hannah Spece,

Pierangiola Bracco

and

Francisco Javier Medel

submission deadline 31 Jan 2026 | 4 articles | Viewed by 9451 | Submission Open

Keywords: UHMWPE; highly crosslinked UHMWPE; HXLPE; PEEK; PEKK; PAEK; additive manufacturing; AM; 3D printing

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Innovative Bioengineering Paradigms for Cardiac Repair: Cell-Based and Cell-Free Approaches

edited by

Jialiang Liang

and Xingyu He

submission deadline 31 Jan 2026 | 3 articles | Viewed by 7518 | Submission Open

Keywords: cardiac regeneration; cardiac repair; stem cells; tissue engineering; cell transplant; gene delivery; extracellular vesicles; nanotechnology; immunomodulation; lineage reprogramming

(This special issue belongs to the Section Regenerative Engineering)

Disease Diagnosis and Therapy Using Viral Vectors

edited by

Srividhya Venkataraman

and

Kathleen Hefferon

submission deadline 31 Jan 2026 | 1 articles | Viewed by 7163 | Submission Open

Keywords: gene therapy; viral vectors; genetic disease

(This special issue belongs to the Section Cellular and Molecular Bioengineering)

Low-Back Pain: Assessment and Rehabilitation Research

edited by

Giustino Varrassi

and

Giacomo Farì

submission deadline 31 Jan 2026 | 2 articles | Viewed by 5336 | Submission Open

Keywords: chronic pain; wearable technologies; computational modeling; biomechanical analysis; assistive devices; sensor-based functional assessments

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Bioengineering in a Generative AI World

edited by

Yifan Zhao

, Ulas Bagci and Yuxiang Zhou

submission deadline 31 Jan 2026 | 2 articles | Viewed by 5330 | Submission Open

Keywords: generative AI; bioengineering; machine learning; synthetic biology; drug discovery

(This special issue belongs to the Section Biosignal Processing)

New Sights of Machine Learning and Digital Models in Biomedicine

edited by Hatem Alhadainy

submission deadline 31 Jan 2026 | 3 articles | Viewed by 4369 | Submission Open

Keywords: machine learning; biomedical imaging; predictive modeling; medical data analytics; genomics; precision medicine; bioinformatics; machine learning algorithms; computer-aided diagnosis; imaging analysis; clinical decision support; electronic health records (EHR); disease prediction simulation models; virtual patients; drug discovery; health informatics

(This special issue belongs to the Section Biosignal Processing)

Digital Technologies to Improve Diagnostic Cytopathology: Future Outlook

edited by

Enrico Giarnieri

submission deadline 31 Jan 2026 | 1 articles | Viewed by 4155 | Submission Open

Keywords: machine learning; cytopathology; digital cytology; computer-aided diagnosis; virtual reality; natural language process

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Biomedical Engineering and Biomarkers in Plastic and Reconstructive Surgery Applications

edited by Saif Badran and Matthew Wood

submission deadline 31 Jan 2026 | 3 articles | Viewed by 3037 | Submission Open

Keywords: tissue engineering; 3D bioprinting; personalized medicine; metabolic biomarkers; regenerative medicine; advanced biomaterials

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Artificial Intelligence in Neurodegenerative Disorders: Advances in Diagnosis, Prognosis and Treatment

edited by Shayne Chau and Mohd. Farooq Shaikh

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2951 | Submission Open

Keywords: artificial intelligence; neurodegenerative disorders; machine learning in neurology; diagnosis; treatment; prognosis

(This special issue belongs to the Section Biosignal Processing)

Advances in Polyhydroxyalkanoate (PHA) Production, 5th Edition

edited by

Martin Koller

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2848 | Submission Open

Keywords: polyhydroxyalkanoate (PHA); biopolyesters; bioprocess design; sustainable development

(This special issue belongs to the Section Biochemical Engineering)

Data Modeling and Algorithms in Biomedical Applications

edited by

Ivan Ganchev Ivanov

submission deadline 31 Jan 2026 | 3 articles | Viewed by 2840 | Submission Open

Keywords: computer models; algorithms; biomedical applications; predictive modeling; machine learning; data analysis; data modeling; AI applications

(This special issue belongs to the Section Biosignal Processing)

New Sights of Mathematical Modeling in Biomedicine: Updates and Direction

edited by

Kayode Oshinubi

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2797 | Submission Open

Keywords: mathematical modeling; machine learning; predictive modeling; data modeling; biological systems

(This special issue belongs to the Section Biosignal Processing)

Printable Biomaterials from Tissue Engineering to Orthopedics: Fabrication, Mechanical Performance, and Biological Behavior

edited by

Gianpaolo Serino

and

Gulden Camci-Unal

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2182 | Submission Open

Keywords: advanced printable biomaterials; biocompatibility; bioactivity; mechanical properties; physical and chemical properties

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Dental Pulp Stem Cells in Clinical Application: Present and Future Perspectives

edited by

Ciro Gargiulo Isacco

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1753 | Submission Open

Keywords: dental pulp stem cells; cell injections; modified cells; cell sheets; cell spheroids; regeneration; damaged tissues; immunomodulation

(This special issue belongs to the Section Regenerative Engineering)

Recent Advances in Periodontal Tissue Engineering

edited by

Atsushi Saito

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1600 | Submission Open

Keywords: periodontal disease; periodontal tissue engineering; periodontal regeneration; biomaterials; soft and hard tissue regeneration

(This special issue belongs to the Section Regenerative Engineering)

Radiation Imaging and Therapy for Biomedical Engineering

edited by Bharat Guthikonda and Stanley Hoang

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1465 | Submission Open

Keywords: radiation imaging; radiation therapy; biomedical engineering; diagnostic technologies; therapeutic innovations

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Metabolic MRI and Beyond: Emerging Technologies and Translational Biomedical Applications

edited by Kejia Cai and Mohan Jayatilake

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1208 | Submission Open

Keywords: metabolic MRI; CEST MRI; deuterium metabolic imaging; hyperpolarized 13C MRI; Arterial Spin Labeling (ASL); artificial intelligence in MRI; MR spectroscopy

(This special issue belongs to the Section Biosignal Processing)

Advances in Spinal Biomechanics: Integrating In Vivo, In Vitro, and Computational Approaches in the Era of Evolving Spine Technologies

edited by

Byung Ho Lee

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1189 | Submission Open

Keywords: spinal biomechanics; computational modelling; spinal disorders; implants; finite element modeling

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Recent Advances in Cardiothoracic Assist Devices

edited by Suvitesh Luthra and

Enrique Berjano

submission deadline 31 Jan 2026 | 1 articles | Viewed by 981 | Submission Open

Keywords: mechanical circulatory support; VAD; OCS; LBE and EVLP; total artificial heart; heart failure; maglev and axial flow pumps; minimally invasive; wireless power; biocompatibility; AI in cardiac devices

(This special issue belongs to the Section Regenerative Engineering)

New Sights of AI Tools and Deep Learning in Biomedicine

edited by

Mirpouya Mirmozaffari

submission deadline 31 Jan 2026 | 1 articles | Viewed by 895 | Submission Open

Keywords: artificial intelligence; machine learning; optimization; healthcare management; operation research; biomedicine

(This special issue belongs to the Section Biosignal Processing)

Advances in Biomolecular Engineering for Regenerative Therapeutics

edited by

Christopher Robinson

, Paul Jordan Christo and

Matthew Chung

submission deadline 31 Jan 2026 | 1 articles | Viewed by 874 | Submission Open

Keywords: regenerative medicine; growth factors; gene therapy; exosomes; extracellular vesicles; proteomics; genomics; CRISPR; stem cells

(This special issue belongs to the Section Regenerative Engineering)

Biofabrication Technologies: Novel Tools for More Effective Personalized Medicine and Regenerative Therapies

edited by

Giovanni Vozzi

Paola Nieri

and Mauro Di Stasi

submission deadline 31 Jan 2026 | 2 articles | Viewed by 740 | Submission Open

Keywords: biodegradable polymers; biocompatible polymers; biomedical applications; biomaterials; renewable biomaterials; tissue engineering; regenerative medicine; biofabrication and bioprinting; personalized medicine; 3D tissue models

(This special issue belongs to the Section Regenerative Engineering)

Deep Learning for Medical Applications: Challenges and Opportunities

edited by

Roberta Hlavata

, Robert Hudec and

Patrik Kamencay

submission deadline 31 Jan 2026 | Viewed by 583 | Submission Open

Keywords: deep neural networks; deep learning; machine learning; medical applications; healthcare AI; medical imaging; multimodal data integration; model interpretability

(This special issue belongs to the Section Biosignal Processing)

Emerging Artificial Intelligence Trends for Predictive Analytics and Personalized Healthcare

edited by

Josu Maiora

Maria Begoña Sanz Echevarría

and

Manuel Graña

submission deadline 31 Jan 2026 | Viewed by 471 | Submission Open

Keywords: artificial intelligence; machine learning; deep learning; predictive analytics; wearable sensors; medical devices; medical image analysis

(This special issue belongs to the Section Biosignal Processing)

Neuroimaging Techniques for Central Autonomic System: Methodologies and Applications

edited by Antonio Ferretti and Mauro Gianni Perrucci

submission deadline 31 Jan 2026 | Viewed by 427 | Submission Open

Keywords: integration of EEG; fMRI; fNIRS; or other neuroimaging modalities; fMRI preprocessing; autonomic system; central autonomic network; physiological noise; brainstem; epilepsy; sudep; valsalva maneuver; functional connectivity; integration of neuroimaging and extended-reality protocols

(This special issue belongs to the Section Biosignal Processing)

Dental Biomaterials: Current and Future Perspectives

edited by Sandro Basso Bitencourt,

Emily Vivianne Freitas da Silva

and Natalia Bastos-Bitencourt

submission deadline 31 Jan 2026 | Viewed by 385 | Submission Open

Keywords: dental materials; 3D printing; ceramics; CAD/CAM; bioactivity

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Cardiac Digital Twins and AI: From Multi-Modal Modeling to Medical Implementation

edited by Lei Li,

Rodrigo Weber Dos Santos

and Julia Camps

submission deadline 31 Jan 2026 | Viewed by 321 | Submission Open

Keywords: cardiac digital twins; multi-modal modeling; AI in cardiology; clinical translation; multi-modal data integration; personalized cardiac modeling; real-time simulation; cardiovascular precision medicine

(This special issue belongs to the Section Biosignal Processing)

Robotics and Virtual Reality for Rehabilitation

edited by

Marcos José Navarro-Santana

submission deadline 31 Jan 2026 | Viewed by 289 | Submission Open

Keywords: rehabilitation technology; wearable robotics; telerehabilitation; virtual reality; artificial intelligence; personalized therapy

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Artificial Intelligence in Autoimmune Diseases

edited by

Fulvia Ceccarelli

and

Marco Sciandrone

submission deadline 31 Jan 2026 | Viewed by 240 | Submission Open

Keywords: artificial intelligence; autoimmune diseases; machine learning; personalized medicine; predictive analytics

(This special issue belongs to the Section Biosignal Processing)

Advanced Data Processing for Wearable Neurophysiological Monitoring in Real-World Settings

edited by

Vincenzo Ronca

and

Pietro Aricò

submission deadline 31 Jan 2026 | Viewed by 236 | Submission Open

Keywords: wearable neurophysiological signals; artifact removal; real-world monitoring; machine learning for biosignals; human factors; bioinformatics; bioengineering

(This special issue belongs to the Section Biosignal Processing)

Targeting Biofilm-Associated Infections: Mechanistic Insights, Challenges, and Therapeutic Innovations

edited by

Zhaojun Jia

and Jianglong Yan

submission deadline 31 Jan 2026 | Viewed by 198 | Submission Open

Keywords: biofilm formation; antimicrobial resistance; biofilm disruption; bacterial infections; biomedical device-associated infections (BAIs); immunomodulatory biomaterials; antibacterial materials; antibacterial surface modification; photocatalytic disinfection; sonodynamic antibacterial therapy

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Biomechanical Assessment in Rehabilitation and Performance

edited by

Eleftherios Paraskevopoulos

and

Dimitris G. Mandalidis

submission deadline 31 Jan 2026 | Viewed by 170 | Submission Open

Keywords: motion capture analysis; postural control assessment; gait analysis; wearable sensor technologies; muscle activation studies; joint kinematics; sports injuries; sports therapy

(This special issue belongs to the Section Biomechanics and Sports Medicine)

Neuro-Bioengineering Innovations: Integrative Approaches for Diagnostics, Implants and Regenerative Therapies

edited by Frank D. Vrionis,

Maohua Lin

, Yufei Tang and Mohsen Ahmadi

submission deadline 31 Jan 2026 | Viewed by 148 | Submission Open

Keywords: machine learning; artificial intelligence; spinal cord; neural interface technologies; implantable micro-devices; neuroimaging; explainable AI; finite element modeling; physics-informed neural networks (PINNs); bioinformatics; smart sensors; muscle modeling; biomechanics

(This special issue belongs to the Section Biosignal Processing)

MRI Techniques for Disease Detection

edited by Christine Fernandez-Maloigne

submission deadline 31 Jan 2026 | Viewed by 145 | Submission Open

Keywords: MRI; disease detection; artificial intelligence; deep learning

(This special issue belongs to the Section Biosignal Processing)

Intelligent Healthcare and Auditory Health: Machine Learning-Based Multimodal Biomedical Data Mining for Diagnosis

edited by

Meihong Wu

and

Yunfeng Wu

submission deadline 31 Jan 2026 | Viewed by 144 | Submission Open

Keywords: computer-aided diagnosis; speech signal processing; auditory information processing; neurodegenerative diseases; wearable devices; health informatics; multimodal fusion; telemedicine; rehabilitation engineering; noise-robust algorithms; acoustic feature extraction; cognitive impairment screening; end-to-end speech enhancement

(This special issue belongs to the Section Biosignal Processing)

Integrative Approaches: The Intersection of Brain–Computer Interfaces and Retinal Health

edited by Mouayad Masalkhi

submission deadline 31 Jan 2026 | Viewed by 136 | Submission Open

Keywords: brain– computer interfaces; retinal disorders; ophthalmology; visual prosthetics; assistive technologies; neurotechnology

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advancing Care in Neuroimmunology: The Role of Digital Tools in Multiple Sclerosis and Related Disorders

edited by

Tjalf Ziemssen

submission deadline 31 Jan 2026 | Viewed by 133 | Submission Open

Keywords: multiple sclerosis (MS); neuromyelitis optica spectrum disorders (NMOSD); autoimmune encephalitides; neuroimmunological diseases; mobile health (mHealth) applications; wearable sensors; telemedicine; artificial intelligence (AI)-based diagnostic support; digital biomarkers

(This special issue belongs to the Section Biosignal Processing)

Technologies for the Regeneration of Bone Tissue

edited by

Yvonne Reinwald

Ying Yang

Ruchi Mishra Tiwari

and Yanny Marliana Baba Ismail

submission deadline 31 Jan 2026 | Viewed by 132 | Submission Open

Keywords: bone tissue; regenerative medicine; immunomodulation; angiogenesis; growth factors; mechanical stimulation

(This special issue belongs to the Section Regenerative Engineering)

Advanced Imaging Techniques for Neuroscience

edited by Dhairya A. Lakhani

submission deadline 31 Jan 2026 | Viewed by 128 | Submission Open

Keywords: machine learning; functional MRI (fMRI); resting-state fMRI; ultra-high-field MRI; connectomics; MR spectroscopy; molecular imaging; MR perfusion; high-grade glioma; ischemic stroke; vessel wall imaging; neurodegenerative disease; PET/MR

(This special issue belongs to the Section Biosignal Processing)

Advancements in Drug Design and Delivery for Neuropsychological Disorders: Integrating Bioinformatics and Nanotechnology

edited by

Tahmineh Mokhtari

submission deadline 31 Jan 2026 | Viewed by 123 | Submission Open

Keywords: neuropsychological disorders; drug design; drug delivery; bioinformatics; nanotechnology; computational drug design; targeted therapies; neuropharmacology; nanomedicine; bioengineering

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Motor Control Techniques: Integrating Motor Neuroscience and Applied Mathematics

edited by

Osmar Pinto Neto

submission deadline 31 Jan 2026 | Viewed by 117 | Submission Open

Keywords: motor control; computational neuroscience; neural oscillations; electromyography (EMG); neuromodulation (tDCS; TMS); Bayesian models; motor learning and adaptation; biomechanics; rehabilitation engineering; Parkinson's disease

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Biomedical Materials Expansion in Tissue Regeneration: Material and Tissue Evaluation

edited by

Osamu Yamamoto

and Takahiro Kawai

submission deadline 31 Jan 2026 | Viewed by 100 | Submission Open

Keywords: polymers; metals; gels; collagen; in vivo/in vitro evaluation; cells; animal model; clinical trial; biological tissue regeneration

(This special issue belongs to the Section Regenerative Engineering)

Emerging Applications and Insights for Life and Biomaterial Sciences Through Correlated Volume and Electron Microscopy Advances

edited by

Eduardo Rosa-Molinar

and Mark Sanders

submission deadline 10 Feb 2026 | Viewed by 153 | Submission Open

Keywords: resin electron microscopy; volume electron microscopy; correlated electron microscopy; in situ electron microscopy; analytical electron microscopy; correlated cryo-electron tomography

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Bioengineering Platforms for Drug Delivery

edited by Anam Ahsan

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2066 | Submission Open

Keywords: biomaterials; drug delivery; nanotechnology; nanobiotechnology; bioengineering platforms; targeted drug delivery; chemotherapy; bioconjugation; disease management; therapeutic agents

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Wearable Devices for Neurotechnology

edited by Basilio Vescio and

Fabiano Bini

submission deadline 25 Feb 2026 | Viewed by 247 | Submission Open

Keywords: wearable devices; neurotechnology; brain– computer interfaces; EEG; wearable gait analysis

(This special issue belongs to the Section Biosignal Processing)

Recent Advancements in Wound Healing and Repair

edited by

Wing Sum Siu

submission deadline 28 Feb 2026 | 6 articles | Viewed by 21085 | Submission Open

Keywords: wound healing; wound repair; bioactive dressings; stem cell therapy; tissue engineering; chronic wounds; biomaterials; imaging technologies; nanoparticles; antibacterial properties; biopolymers; wound dressing; cell and molecular biology

(This special issue belongs to the Section Regenerative Engineering)

Musculoskeletal Function in Health and Disease

edited by Adrian Paul Harrison and Else Marie Bartels

submission deadline 28 Feb 2026 | 6 articles | Viewed by 15893 | Submission Open

Keywords: musculoskeletal disorders; muscle injury; pre-habilitation and rehabilitation; healthcare; wearable technology; quality of life; sport science; sport medicine

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Physical Therapy and Rehabilitation

edited by

Seong-Gil Kim

and Jin-Seop Kim

submission deadline 28 Feb 2026 | 8 articles | Viewed by 15602 | Submission Open

Keywords: physical therapy; rehabilitation; exercise prescription; manual therapy; telerehabilitation; telehealth; virtual reality; wearable devices; musculoskeletal rehabilitation; neurological rehabilitation; post-operative recovery; chronic pain management; injury prevention; multidisciplinary rehabilitation; patient-centered care; personalized rehabilitation; functional recovery; mobility improvement; pain alleviation; mental health in rehabilitation; long-term wellness

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Application of Artificial Intelligence in Complex Diseases

edited by Yan Zhu

submission deadline 28 Feb 2026 | 6 articles | Viewed by 14257 | Submission Open

Keywords: artificial intelligence; machine learning; complex diseases; healthcare; diagnostics; predictive modeling; medical imaging; ethics in AI

(This special issue belongs to the Section Biosignal Processing)

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