Advances in Biomolecular Engineering for Regenerative Therapeutics

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 848

Special Issue Editors


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Guest Editor

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Guest Editor
Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Interests: regenerative medicine; gene therapy; stem cells; platelet-rich plasma
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Guest Editor Assistant
Department of Pain Medicine, Division of Anesthesia, Critical Care and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Interests: cancer pain; education; neuromodulation

Special Issue Information

Dear Colleagues,

The field of regenerative medicine is rapidly transforming, driven by innovations and developments in biomolecular engineering. This Special Issue of Bioengineering aims to highlight cutting-edge research at the intersection of molecular design, biomaterials science, and therapeutic delivery systems that collectively enhance tissue repair and regeneration. We invite original research articles, reviews, and perspectives that explore the development and application of engineered biomaterials, bioactive scaffolds, and molecular delivery platforms—such as growth factors, gene and RNA therapies, and extracellular vesicles—that modulate the cellular microenvironment to activate endogenous healing pathways.

Contributions that integrate omics-guided discovery, synthetic biology, or biophysical cues to design next-generation regenerative therapeutics are especially encouraged. This Special Issue seeks to provide a platform for interdisciplinary work that bridges molecular bioengineering with translational application across musculoskeletal, neural, cardiovascular, and other tissue systems. By showcasing innovative strategies and mechanistic insights, this collection will inform the development of safer, more effective, and better targeted regenerative solutions.

We welcome submissions from academia, clinical researchers, and industry partners working to redefine the future of regenerative medicine through molecular-level innovation.

Dr. Christopher Robinson
Dr. Paul Jordan Christo
Guest Editors

Dr. Matthew Chung
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • regenerative medicine
  • growth factors
  • gene therapy
  • exosomes
  • extracellular vesicles
  • proteomics
  • genomics
  • CRISPR
  • stem cells

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Published Papers (1 paper)

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Review

16 pages, 3513 KB  
Review
Tinkering with Blood: Optimizing the Coagulation System for Therapeutic Purposes
by Eduardo Anitua and Sabino Padilla
Bioengineering 2025, 12(12), 1301; https://doi.org/10.3390/bioengineering12121301 - 26 Nov 2025
Viewed by 538
Abstract
Blood is a multitask, fluid tissue that is considered as an endless goldmine for regenerative therapies. This connective tissue carries myriad multidomain proteins as the workhorse of biological functions integrated in complex molecular networks. Among them, the coagulation system stands out, with platelets [...] Read more.
Blood is a multitask, fluid tissue that is considered as an endless goldmine for regenerative therapies. This connective tissue carries myriad multidomain proteins as the workhorse of biological functions integrated in complex molecular networks. Among them, the coagulation system stands out, with platelets and plasma coagulation proteins playing multiple roles in clotting, defense and tissue repair, the latter of which is the final byproduct process stemming from the hemostatic–inflammatory, cell-reprogramming and inflammation resolution after a tissue injury. By mimicking coagulation and hemostasis but lacking inflammatory properties, platelet-rich plasma (PRP) is emerging as an innovative autologous therapy operating as a local delivery system of growth factors. Processing of the patient blood to manufacture PRP encompasses blood anticoagulation; blood deconstruction through centrifugation and fractionation; and activation of plasma, endowing the applied product with anti-inflammatory, trophic, antifibrotic and antialgic properties in a context-dependent manner. However, the field of PRPs faces controversies due to the heterogeneity of their biological compositions and modalities of application. Moreover, there are some drawbacks derived from patient age and some other conditions, all impinging negatively on PRP clinical outcomes. Standardization of the manufacturing process, elaboration of guidelines of application and use of allogenic PRPs are emerging as possible solutions to surmount these pitfalls. Full article
(This article belongs to the Special Issue Advances in Biomolecular Engineering for Regenerative Therapeutics)
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