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Bioengineering
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Advances in Spinal Biomechanics: Integrating In Vivo, In Vitro, and...
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Advances in Spinal Biomechanics: Integrating In Vivo, In Vitro, and Computational Approaches in the Era of Evolving Spine Technologies

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 96

Special Issue Editor

Prof. Dr. Byung Ho Lee

E-Mail Website
Guest Editor
Severance Hospital, College of Medicine, Yonsei University, Seodaemun-gu, Seoul, Republic of Korea
Interests: cervical spine; biomechanics; C5 palsy; subsidence; radiologic outcomes; freehand pedicle screw insertion technique
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the latest advances in spinal biomechanics, their integration into in vivo clinical research, in vitro experimental studies, and computational modeling. As spinal disorders and surgical interventions become increasingly complex, biomechanical insights are essential to optimize treatment strategies and implant designs. This Special Issue therefore aims to present innovative research on artificial disc replacement, long spinal fusion constructs, regional fixation methods (cervical, thoracic, lumbar), and the biomechanical relevance of sagittal alignment. We welcome original contributions that explore spine biomechanics through finite element modeling, mechanical testing, or clinical evaluation, as well as studies that address the biomechanical performance of surgical techniques and materials in spinal fixation. The scope of this Special Issue includes novel device development, implant validation, the influence of aging, degeneration, and trauma on spinal stability, and the design of innovative research methodologies. It will also serve as a platform for interdisciplinary collaboration among spine surgeons, biomedical engineers, and researchers, with the ultimate goal of enhancing clinical outcomes through biomechanical research.

Prof. Dr. Byung Ho Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • spinal biomechanics
  • computational modelling
  • spinal disorders
  • implants
  • finite element modeling

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Published Papers (1 paper)

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Research

12 pages, 1866 KB  
Article
Biomechanical Effects of Cement Augmentation and Prophylactic Vertebroplasty on Adjacent Segment Stability in Multilevel Spinal Fusion: A Finite Element Analysis
by Jae Won Shin, Dae Hyeon Kim, Ki Mun Kang, Tae Hyun Park, Yu Rim Oh, Sung Jae Lee and Byung Ho Lee
Bioengineering 2025, 12(10), 1071; https://doi.org/10.3390/bioengineering12101071 - 1 Oct 2025
Abstract
Background: Multilevel posterior spinal fusion to T10 often encounters complications such as screw loosening and proximal junctional kyphosis. Cement augmentation or prophylactic vertebroplasty is used to prevent these, but their biomechanical effects remain unclear. Methods: A validated finite element model (T8–pelvis) from CT [...] Read more.
Background: Multilevel posterior spinal fusion to T10 often encounters complications such as screw loosening and proximal junctional kyphosis. Cement augmentation or prophylactic vertebroplasty is used to prevent these, but their biomechanical effects remain unclear. Methods: A validated finite element model (T8–pelvis) from CT data of a 57-year-old male was tested in five configurations: fusion only, fusion with cement augmentation at T10, T10–T11, T10–T11 plus T9 vertebroplasty, and T10–T11 plus T8–T9 vertebroplasty. Range of motion (ROM), intradiscal pressure (IDP), posterior ligament/facet stress, and cement–bone interface stresses were analyzed under a 400 N follower load and 10 N·m moments. Results: Cement augmentation at the upper instrumented vertebra produced <5% changes in ROM, IDP, and posterior ligament/facet stresses compared with fusion only, indicating preserved stability. Prophylactic vertebroplasty redistributed stress proximally, with elevated cement–bone interface stresses localized at T9 when vertebroplasty was performed at a single adjacent level (T9) and distributed to both T8 and T9 when performed at two adjacent levels (T8–9)—with T9 stressed mainly during lateral bending and extension, and T8 during flexion and lateral bending. Conclusion: Cement augmentation alone did not compromise adjacent-level biomechanics, but prophylactic vertebroplasty created abnormal stress concentrations at adjacent interfaces, potentially increasing fracture risk. These findings highlight the need for careful patient selection and further studies in osteoporotic populations. Full article
(This article belongs to the Special Issue Advances in Spinal Biomechanics: Integrating In Vivo, In Vitro, and Computational Approaches in the Era of Evolving Spine Technologies)
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