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Bioengineering
Special Issues
Tissue Engineering for Skin Repair and Regeneration
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Tissue Engineering for Skin Repair and Regeneration

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (10 December 2023) | Viewed by 8041

Special Issue Editors

Dr. Agata Janowska

E-Mail Website
Guest Editor
Department of Dermatology, University of Pisa, Pisa, Italy
Interests: clinical dermatology; dermatopathology; melanoma; dermatosurgery
Dr. Teresa Oranges

E-Mail Website
Co-Guest Editor
Department of Dermatology, University of Pisa, Via Roma 67, 56126 Pisa, Italy
Interests: C-reactive protein; temperature; pH; SENSORS; biosensors; wound healing; chronic pruritus; itch; pruritus; wounds; itch in wounds; itch management
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Regenerative medicine and tissue engineering allow the replacement, repair or regeneration of damaged tissues such as skin wounds, burns or surgical dehiscence. Tissue engineering represents an evolution of the classic surgery allowing the possibility of associating the potentiality of living cell transplantation with the technology of artificial structures. The aim of these technologies is to find alternative materials that ensure biocompatibility, low immunogenicity and bioactive properties and to create a skin substitute that is easy to handle, durable and efficacious.

Thus, the aim of this Special Issue is to report new treatments and current advances in Wound Healing, considering cellular mechanisms and pathological outcomes. The scientific contributions on these topics may be submitted in the form of original articles and reviews. We look forward to receiving your contributions. Topics of interest for this Special Issue” Tissue Engineering for Skin Repair and Regeneration” include, but are not limited to, the following:

  • tissue engineering; 
  • drug delivery;
  • new dressings;
  • stem cell therapy;
  • 3D printed skin.

Dr. Agata Janowska
Dr. Teresa Oranges
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

18 pages, 10612 KiB  
Article
Modified Sol–Gel Synthesis of Mesoporous Borate Bioactive Glasses for Potential Use in Wound Healing
by Farzad Kermani, Hossein Sadidi, Ali Ahmadabadi, Seyed Javad Hoseini, Seyed Hasan Tavousi, Alireza Rezapanah, Simin Nazarnezhad, Seyede Atefe Hosseini, Sahar Mollazadeh and Saeid Kargozar
Bioengineering 2022, 9(9), 442; https://doi.org/10.3390/bioengineering9090442 - 5 Sep 2022
Cited by 21 | Viewed by 3449
Abstract
In this study, we successfully utilized nitrate precursors for the synthesis of silver (Ag)-doped borate-based mesoporous bioactive glass (MBGs) based on the 1393B3 glass formulation in the presence of a polymeric substrate (polyvinyl alcohol (PVA)) as a stabilizer of boric acid. The X-ray [...] Read more.
In this study, we successfully utilized nitrate precursors for the synthesis of silver (Ag)-doped borate-based mesoporous bioactive glass (MBGs) based on the 1393B3 glass formulation in the presence of a polymeric substrate (polyvinyl alcohol (PVA)) as a stabilizer of boric acid. The X-ray diffraction (XRD) analysis confirmed the glassy state of all the MBGs. The incorporation of 7.5 mol% Ag into the glass composition led to a decrease in the glass transition temperature (Tg). Improvements in the particle size, zeta potential, surface roughness, and surface area values were observed in the Ag-doped MBGs. The MBGs (1 mg/mL) had no adverse effect on the viability of fibroblasts. In addition, Ag-doped MBGs exhibited potent antibacterial activity against gram-positive and gram-negative species. In summary, a modified sol–gel method was confirmed for producing the Ag-doped 1393B3 glasses, and the primary in vitro outcomes hold promise for conducting in vivo studies for managing burns. Full article
(This article belongs to the Special Issue Tissue Engineering for Skin Repair and Regeneration)
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14 pages, 2626 KiB  
Article
3D-Printed PCL Scaffolds Combined with Juglone for Skin Tissue Engineering
by Musa Ayran, Akif Yahya Dirican, Elif Saatcioglu, Songul Ulag, Ali Sahin, Burak Aksu, Alexa-Maria Croitoru, Denisa Ficai, Oguzhan Gunduz and Anton Ficai
Bioengineering 2022, 9(9), 427; https://doi.org/10.3390/bioengineering9090427 - 30 Aug 2022
Cited by 26 | Viewed by 3795
Abstract
Skin diseases are commonly treated with antihistamines, antibiotics, laser therapy, topical medications, local vitamins, or steroids. Since conventional treatments for wound healing (skin allografts, amnion, xenografts, etc.) have disadvantages such as antigenicity of the donor tissue, risk of infection, or lack of basement [...] Read more.
Skin diseases are commonly treated with antihistamines, antibiotics, laser therapy, topical medications, local vitamins, or steroids. Since conventional treatments for wound healing (skin allografts, amnion, xenografts, etc.) have disadvantages such as antigenicity of the donor tissue, risk of infection, or lack of basement membrane, skin tissue engineering has become a popular new approach. The current study presents the design and fabrication of a new wound-dressing material by the addition of Juglone (5-hydroxy-1,4-naphthoquinone) to a 25% Polycaprolactone (PCL) scaffold. Juglone (J) is a significant allelochemical found in walnut trees and, in this study is used as a bioactive material. The effects of different amounts of J (1.25, 2.5, 5, 7.5, and 10 mg) on the biocompatibility, mechanical, chemical, thermal, morphological, and antimicrobial properties of the 3D-printed 25% PCL scaffolds were investigated. The addition of J increased the pore diameter of the 25% PCL scaffold. The maximum pore size (290.72 ± 14 µm) was observed for the highest amount of J (10 mg). The biocompatibility tests on the scaffolds demonstrated biocompatible behavior from the first day of incubation, the 25% PCL/7.5 J scaffold having the highest viability value (118%) among all of the J-loaded scaffolds. Drug release of J into phosphate buffered saline (PBS) at pH 7.4 showed that J was completely released from all 25% PCL/J scaffolds within 7 days of incubation. Full article
(This article belongs to the Special Issue Tissue Engineering for Skin Repair and Regeneration)
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