Application of Cells, Bio-Nanovesicles and Bio-Nanoparticles for Regenerative Therapy

Dear Colleagues,

Cells with therapeutic uses have attracted a lot of interest in the field of regenerative medicine. The native origin of cell therapies is not yet fully understood, and more research is needed to allow their therapeutic potential to be fully exploited. Cells for use in therapy can be obtained in vitro from different tissue sources and show heterogeneity regarding their fate, phenotype, and functions. Thus, it has become necessary to establish new methods and create standards for comparing these distinct populations of cells that have uses in therapy. As therapeutic cells’ functions are mainly supported by paracrine pathways that consist of several regulatory factors (such as cytokines and growth factors) and nucleic acids that can be secreted or packaged into extracellular vesicles, cellular communication can be induced by the exosomal contents, consisting of proteins, DNA, and RNA cargo (especially microRNA and long non-coding RNA), as well as metabolomes. The role and composition of exosomal contents vary depending on the source of the exosome. The identification of these factors may open the way for the use of cell-free therapeutic tools to repair and treat injured tissues.

The aim of this Special Issue is to highlight the recent developments regarding the therapeutic properties and mechanisms of cell-based and cell-free therapy. Original research, systematic reviews, and review articles are welcome.

Dr. Prakash Gangadaran
Guest Editor

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