Cardiovascular Bioprostheses

Dear Colleagues,

Cardiovascular bioprostheses represent a rapidly evolving field at the intersection of basic science, translational research, and clinical application. Advances in biomaterials, tissue engineering, biomechanics, and immunomodulation have significantly improved the performance and durability of heart valve substitutes, vascular grafts, and other cardiovascular implants. However, major challenges remain with respect to long-term functionality, biocompatibility, degeneration, and patient-specific optimization.

This Special Issue aims to provide a comprehensive platform for cutting-edge research on cardiovascular bioprostheses, with a strong emphasis on translation and bench-to-bedside approaches. We welcome contributions spanning fundamental research, preclinical development, and clinical validation, highlighting how mechanistic insights and innovative experimental models can be effectively translated into improved therapeutic solutions. Particular attention is given to interdisciplinary strategies that integrate engineering, biology, and medicine to accelerate clinical impact.

In line with responsible and sustainable research practices, the implementation of the 3R principles (Replacement, Reduction, and Refinement) in cardiovascular research is emphasized. Novel in vitro models, computational approaches, and advanced testing platforms that reduce reliance on animal experiments while enhancing predictive power are especially encouraged.

By bringing together basic researchers, engineers, translational scientists, and clinicians, this Special Issue seeks to foster innovation, collaboration, and critical discussion to advance the next generation of cardiovascular bioprostheses.

Dr. Mareike Barth
Guest Editor

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