Advanced 3D Cell Culture Technologies and Formats, 2nd Edition
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 35
Special Issue Editors
Interests: 3D cell culture; bioreactors; tissue engineering; biomaterials; stem cells; cell expansion and differentiation; dynamic cultivation; hypoxia
Special Issues, Collections and Topics in MDPI journals
Interests: biotechnology; bioengineering; bioprocess engineering; 3D cell culture; tissue engineering; bioreactors; stem cell manufacturing; stem cells; biomaterials; scaffolds
Special Issue Information
Dear Colleagues,
Approved cells and cellular products (i.e., extracellular vesicles) for cell-based therapy applications carry considerable promise for the treatment of a broad variety of diseases and several (stem) cell therapies. However, the therapeutic potential of cells is not fully exploited at present.
Traditional cell culture conditions do not represent the physiological conditions of the native cellular environment. For example, two-dimensional plastic surfaces are widely used as standard conditions. However, these conditions are proven to result in non-physiological behavior of the cells, cell damage, or genetic instability. By contrast, different 3D culture formats have been found to enhance the therapeutic potential of cells and cellular products for cell-based therapies. However, the generation of 3D cultures requires advanced culture technologies, such as novel culture plate geometries, materials, and formats, and scaffold-based and scaffold-free approaches. Some approaches also require integration or combination with dynamic bioreactor systems.
Therefore, the aim of this Special Issue is to highlight these recent advances in 3D cell culture technologies to increase the therapeutic potential of cells and cellular products.
We invite you to contribute original research articles, reviews, and methods regarding novel 3D cell culture technologies that result in an increased therapeutic potential of cells and cellular products (e.g., extracellular vesicles) for cell-based therapy applications. Potential topics might include, but are not limited to, the following:
- 3D culture approaches (aggregates/spheroids/organoids, influence of biomaterials, and biomaterial functionalization);
- Novel bioreactor systems or novel applications of existing systems for the generation and culture of 3D cell cultures or the production of cells and cell-based products from 3D cultures.
This is the second edition of the Special Issue “Advanced 3D Cell Culture Technologies and Formats” https://www.mdpi.com/journal/bioengineering/special_issues/cell_culture_tech
Prof. Dr. Cornelia Kasper
Prof. Dr. Dominik Egger
Guest Editors
Manuscript Submission Information
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Keywords
- 3D cell culture
- bioreactors
- tissue engineering
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Related Special Issue
- Advanced 3D Cell Culture Technologies and Formats in Bioengineering (7 articles)
