Redox-Modulating Strategies in Cancer Therapy: Targeted Thioredoxin System Inhibition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Antioxidant Enzyme Systems".

Deadline for manuscript submissions: 15 October 2024 | Viewed by 124

Special Issue Editor

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Guest Editor
School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology (NJUST), Nanjing 210094, China
Interests: redox regulation; reactive oxygen species; thioredoxin; fluorescent probes; anticancer agent
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The mammalian thioredoxin system, including the core components thioredoxins and thioredoxin reductases as well as the related downstream proteins (e.g., the peroxiredoxins and the methionine sulfoxide reductases), play a crucial role in maintaining cellular redox homeostasis and regulating diverse signaling pathways. Tumor cells harbor a different redox microenvironment from that of noncancer cells, and this redox microenvironment is pivotal for tumor initiation, proliferation and metastasis. Thus, interfering with redox signaling in cancer cells has been recognized as an emerging strategy for cancer therapy.

This Special Issue entitled “Redox-Modulating Strategies in Cancer Therapy: Targeted Thioredoxin System Inhibition” aims to report the latest progress in cancer therapy made via inhibiting the thioredoxin system. All relevant studies are welcome. The Special Issue will include but not be limited to the following topics:

  • Novel small molecules targeting the thioredoxin system for cancer therapy;
  • Novel approaches targeting the thioredoxin system for cancer therapy;
  • Novel action mechanisms of redox-interfering molecules;
  • Novel redox-dependent signaling pathways in cancer cells;
  • The clinical development of thioredoxin system inhibitors;
  • Review/commenting articles related to the topic.

Prof. Dr. Jianguo Fang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • redox
  • cancer
  • thioredoxin
  • peroxiredoxin
  • reactive oxygen species

Published Papers

This special issue is now open for submission.
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