Oxidative Stress in Cell Senescence—2nd Edition

Dear Colleagues,

Following the success of the first edition, we are pleased to launch the second volume of the Special Issue "Oxidative Stress in Cell Senescence". Oxidative stress remains a central driver of cellular senescence and age-related functional decline, influencing key processes such as genome stability, mitochondrial function, proteostasis, inflammation, and tissue regeneration. Increasing evidence also highlights the complex interplay between redox imbalance, metabolic reprogramming, epigenetic regulation, and the senescence-associated secretory phenotype (SASP), emphasizing their contribution to aging and numerous chronic diseases.

At the same time, growing interest has focused on innovative strategies aimed at modulating oxidative stress and delaying senescence, including natural compounds, bioelectrical stimulation, biomaterials, nanotechnology, and regenerative medicine approaches. Understanding these mechanisms is essential for identifying novel therapeutic targets and improving healthy aging.

This Special Issue welcomes original research articles, reviews, and perspectives addressing molecular and cellular mechanisms linking oxidative stress to senescence in different biological systems. Contributions exploring stem cell biology, tissue repair, inflammation, redox signaling, mitochondrial dysfunction, biomarkers of senescence, and emerging therapeutic interventions are particularly encouraged.

We look forward to receiving your valuable contributions and to further advancing this rapidly evolving field. 

Dr. Sara Cruciani
Guest Editor

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