Oxidative Stress and Hearing Loss

Dear Colleagues,

Disabling hearing loss affects 466 million people worldwide (WHO, March 2022). It is heterogeneous in its causes, which can be genetic and/or environmental, such as exposure to noise or ototoxics and aging. It irreversible because the cell types fundamental to hearing, which are auditory neurons, hair cells and supporting cells, do not regenerate in mammals. Although the causes are diverse, when considering the biochemical and molecular mechanisms that lead to the death of these specialized cells, common cues are found. Loss of redox balance leading to the oxidation of molecules essential for cell function and survival is one of the main common mechanisms. Nowadays, the implication of oxidative stress in inner ear damage is well established, however, further research is needed to better understand the exact molecular mechanisms and to prevent redox-mediated forms of hearing loss.

In this Special Issue we want to address these basic aspects from a broad perspective. We will welcome reviews on general redox molecular mechanisms, including those focused on hearing physiopathology, plus original manuscripts focused on understanding how the redox balance is maintained and how the redox balance is lost in the hearing organ, as well as those that address preclinical studies of new molecules aimed at the protection and repair of hearing. We will also welcome complementary manuscripts on related sensory and neural structures, such as the olfactory sensory epithelium and the nervous system.

Dr. Isabel Varela-Nieto
Dr. Francis Rousset
Guest Editors

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