Oxidative Stress and Cardioprotection in Ischemia/Reperfusion Injury: Mechanisms, Biomarkers, and Therapeutic Approaches
A Special Issue of Antioxidants (ISSN 2076-3921) belonging to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 928
Editors
Interests: ischemia–reperfusion injury; cardiomyocyte injury; pharmacological cardioprotection; oxidative stress
Interests: medical biotechnology; gene therapy; vascular remodeling; inflammation; oxidative stress
Special Issues, Collections and Topics in MDPI journals
2. Specialized Immunology Laboratory, Clinical Department of Nephrology, Transplantation Medicine and Internal Diseases, Institute of Internal Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland
Interests: ischemia-reperfusion injury; cardiovascular diseases; oxidative stress; pharmacological protection of tissue injury; cardio-renal-metabolic translation medicine; kidney diseases; extracellular matrix remodeling; matrix metalloproteinases
Special Issue Information
Dear Colleagues,
Ischemia/reperfusion (I/R) injury remains a central challenge in cardiovascular medicine, driven by a complex interplay of oxidative stress, inflammatory signaling, mitochondrial dysfunction, and regulated cell death pathways. Despite significant advances in reperfusion therapies, the translation of cardioprotective strategies from bench to bedside continues to face substantial obstacles, underscoring the need for deeper mechanistic insight and innovative therapeutic approaches.
This Special Issue is conceived as a broad, integrative platform for the dissemination of high-quality original research and critical reviews addressing the multifaceted nature of I/R injury. Rather than restricting its scope to a single signaling cascade or therapeutic modality, it deliberately embraces the biological heterogeneity of I/R pathophysiology and encourages contributions that span molecular, cellular, organ-level, and systemic perspectives.
Submissions encompassing both preclinical experimental models and clinical or epidemiological investigations are welcomed, with particular interest in studies that bridge disciplinary boundaries, integrate multi-omics data, or offer novel conceptual frameworks for understanding cardioprotection.
By fostering interdisciplinary dialog between basic scientists, translational researchers, and clinicians, this collection aspires to advance a more comprehensive, mechanistically grounded understanding of I/R injury and to catalyze the development of effective, evidence-based cardioprotective strategies applicable across diverse clinical contexts.
Dr. Anna Krzywonos-Zawadzka
Dr. Agnieszka Jaźwa-Kusior
Prof. Dr. Iwona Bil-Lula
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mitochondrial dysfunction
- reactive oxygen species (ROS)
- cardioprotective strategies
- conditioning strategies
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