Oxidative Stress and Lung Inflammation

Dear Colleagues,

Acute and chronic lung diseases are characterized by a severe inflammatory process in the lung parenchyma causing diffuse alveolar damage and respiratory failure. When acute inflammation does not resolve completely, chronic inflammation develops. Chronic inflammatory responses clean necrotic debris and apoptotic cells from acute inflammation, inhibit infection spread and repair lung tissue damage. Increased oxidant levels and decreased antioxidant defenses can contribute to the progression of lung damage. Oxidative and nitrosative stress can affect proteins, lipids, carbohydrates and nucleic acids that are the main components of cells. Different molecular pathways counteracting oxidative-mediated tissue damage have therefore been hypothesized for different lung pathogenesis.  The study of oxidative stress can provide insights into the etiopathogenesis of lung disease and favor the discovery of new treatments. 

The aim of this Special Issue will focus on the need to explore the pathophysiology and the molecular pathways involved in the development of lung injury as well as the discovery of new anti-inflammatory and antioxidants agents. This Special Issue is open to receive submissions of full research articles and comprehensive review papers.

Dr. Daniela Impellizzeri
Dr. Marika Cordaro
Dr. Ramona D'Amico
Dr. Rosalba Siracusa
Guest Editors

Manuscript Submission Information

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