Nanotechnology-Based Antimicrobials and Drug Delivery Systems

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Novel Antimicrobial Agents".

Deadline for manuscript submissions: 15 October 2025 | Viewed by 229

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Department of Mechanics, University Politehnica of Bucharest, BN 002, 313 Splaiul Independentei, Sector 6, 060042 Bucharest, Romania
Interests: numerical simulation of ultrasound propagation; nondestructive ultrasonic technique for biomaterials; sound propagation simulation; nonlinear vibrations; plate vibrations; vibrations in aeronautical structures; finite elements analysis
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Special Issue Information

Dear Colleagues,

It is well known that the growing prevalence of antibiotic-resistant bacteria represents a serious global concern. In this context, the nanotechnology-based antimicrobials and drug delivery systems that use nanoscale materials to enhance the efficacy and precision of treatments for infectious diseases has attracted the attention of researchers. These materials could be used either to directly kill pathogens or to deliver drugs more efficiently. Nanoparticles, such as zinc oxide and silver, or polymers, such as chitosan, are recognized for their remarkable antimicrobial properties. They can disrupt bacterial membranes, produce reactive oxygen species, or bind to bacterial DNA, effectively killing pathogens. Moreover, nanocarriers such as liposomes, dendrimers, and polymeric nanoparticles are used in drug delivery to improve solubility, stability, and targeted delivery of pharmaceuticals, reducing side effects and improving therapeutic outcomes. On the other hand, nanotechnology also enables controlled drug release and improved targeting of specific tissues, leading to improved treatment precision. This approach holds particular promise in combating antibiotic-resistant bacteria and improving the bioavailability of drugs in complex diseases. Therefore, this Special Issue welcomes manuscripts and review papers that address these aspects

Prof. Dr. Mihai Valentin Predoi
Dr. Simona Liliana Iconaru
Dr. Carmen Steluta Ciobanu
Guest Editors

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Keywords

  • antimicrobial agents
  • nanocarriers
  • antimicrobial coatings
  • polymers nanocomposite
  • drug delivery systems

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Published Papers (1 paper)

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Research

29 pages, 16106 KiB  
Article
Development of Chrome-Doped Hydroxyapatite in a PVA Matrix Enriched with Amoxicillin for Biomedical Applications
by Steluta Carmen Ciobanu, Daniela Predoi, Simona Liliana Iconaru, Krzysztof Rokosz, Steinar Raaen, Coralia Bleotu and Mihai Valentin Predoi
Antibiotics 2025, 14(5), 455; https://doi.org/10.3390/antibiotics14050455 - 30 Apr 2025
Abstract
Background/Objectives: In this paper, we report the development of the first chrome-doped hydroxyapatite in a poly (vinyl alcohol) (PVA) matrix enriched with amoxicillin for biomedical applications. The development of chromium-doped hydroxyapatite coatings in a PVA matrix enriched with amoxicillin aims to provide [...] Read more.
Background/Objectives: In this paper, we report the development of the first chrome-doped hydroxyapatite in a poly (vinyl alcohol) (PVA) matrix enriched with amoxicillin for biomedical applications. The development of chromium-doped hydroxyapatite coatings in a PVA matrix enriched with amoxicillin aims to provide new biomaterials with improved physico-chemical and biological properties, making them promising candidates for biomedical applications. Methods: Through ultrasound studies, we obtained valuable information on the stability of the samples. X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, metallographic microscopy (MM), and atomic force microscopy (AFM) were employed for the characterization of the samples. The biocompatibility of the CrHApAPV and CrHApAPV-Ax coatings was assessed using the MG63 human osteoblast-like cell line. To evaluate the cytotoxic potential of these coatings, the cell viability was quantified using the MTT assay after 24 h of incubation. The antibacterial activity of the coatings was evaluated with the aid of the reference strain Pseudomonas aeruginosa ATCC 27853 (P. aeruginosa). Results: The XRD patterns of CrHApAPV and CrHApAPV-Ax samples were examined to evaluate the effects of PVA and amoxicillin on the lattice parameters, unit cell volume, and average crystallite sizes. The results of the in vitro antibacterial assay demonstrated that both the CrHApAPV and CrHApAPV-Ax coatings exhibited very good antibacterial properties for all the tested time intervals. Conclusions: Our results underline the stability of the analyzed samples. Moreover, our physico-chemical and biological studies highlight that CrHApAPV and CrHApAPV-Ax coatings could be considered promising materials for biomedical uses. Full article
(This article belongs to the Special Issue Nanotechnology-Based Antimicrobials and Drug Delivery Systems)
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