Clostridioides difficile Infection, 3rd Edition

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".

Deadline for manuscript submissions: 15 May 2025 | Viewed by 1797

Special Issue Editor

Special Issue Information

Dear Colleagues,

We have established two successful editions of the Special Issue “Clostridioides difficile Infection”. There are over twenty excellent papers published. These papers shed light on several aspects of this complex disease, including the clinical course of Clostridioides difficile infection (CDI) and the mortality rate in different settings and patient populations, in addition to the risk factors for CDI recurrence and novel therapeutic approaches. This result encouraged us to launch a third edition on the same topic.

As a continuation of the previous Special Issues, this third edition will also deliver an invaluable compendium of the latest studies on any aspects concerning CDI.

Dr. Guido Granata
Guest Editor

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Keywords

  • Clostridioides difficile
  • Clostridioides difficile infection recurrence
  • antimicrobial use
  • host and microbiota interaction
  • CDI

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Published Papers (1 paper)

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Research

12 pages, 1553 KiB  
Article
Demographic Characteristics and Economic Burden of Clostridioides difficile Infection in Korea: A Nationwide Population-Based Study after Propensity Score Matching
by Jae Myung Cha, Jin Young Yoon, Min Seob Kwak, Moonhyung Lee and Young-Seok Cho
Antibiotics 2024, 13(6), 542; https://doi.org/10.3390/antibiotics13060542 - 10 Jun 2024
Cited by 1 | Viewed by 1372
Abstract
Clostridioides difficile infection (CDI) poses a considerable threat to global public health. However, there have been insufficient propensity score-matched data on its demographic characteristics and economic burden. Using nationwide claims data, we assessed longitudinal changes in the demographic characteristics and economic burden of [...] Read more.
Clostridioides difficile infection (CDI) poses a considerable threat to global public health. However, there have been insufficient propensity score-matched data on its demographic characteristics and economic burden. Using nationwide claims data, we assessed longitudinal changes in the demographic characteristics and economic burden of CDI between 2011 and 2019 after propensity score matching. We performed a regression analysis to compare the differences in the length of hospital stay and medical costs between patients with CDI and controls (gastroenteritis and colitis). The CDI hospitalization rate increased 2.9-fold between 2011 and 2019. The CDI group had higher comorbidity index scores and was more frequently diagnosed at tertiary hospitals and in the Seoul region than the control group (all p < 0.001). The annual incidence rate of CDI/10,000 persons significantly increased in both sexes and all age groups. The length of hospital stay and medical costs were 3.3-fold and 5.0-fold greater, respectively, in the CDI than in the control group (both p < 0.001). Although the length of hospital stay decreased, total medical costs increased in all age groups and both sexes between 2011 and 2019 (all p < 0.001). When compared with the control group, the CDI-attributable length of hospital stay and medical cost were greater by 15.3 days and KRW 3413 (×103), respectively, after matching. In conclusion, CDI incidence, particularly among the elderly population with comorbidities, has been increasing. In addition, the length of hospital stay and total medical costs of the CDI group were greater than those of the control group. Full article
(This article belongs to the Special Issue Clostridioides difficile Infection, 3rd Edition)
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