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Antibiotics
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Advancements in the Control and Diagnosis of Antimicrobial Resistance in...
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Advancements in the Control and Diagnosis of Antimicrobial Resistance in Infectious Diseases

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 2580

Special Issue Editors

Dr. Soyoun Shin

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Guest Editor
Daejeon & Chungcheong reference Lab., Seegene Medical Foundation, Daejeon 35203, Republic of Korea
Interests: molecular microbiology; antimicrobial resistance; infectious diseases
Dr. Alicia Galar

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Guest Editor
Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain
Interests: antimicrobial resistance; therapeutic drug monitoring; antimicrobial stewardship; vaccines; prosthetic-device-related infections; infective endocarditis; infections in patients with heart diseases and pneumonia

Special Issue Information

Dear Colleagues,

The global increase in antimicrobial and antiviral resistance poses a significant threat to human efforts to combat infectious diseases. The importance of proper stewardship in addressing antimicrobial and antiviral resistance is becoming increasingly evident. Understanding the mechanisms underlying antimicrobial and antiviral resistance, as well as developing advanced laboratory diagnostics for early detection, is crucial for effectively controlling and preventing these resistance phenomena.

For this Special Issue, we invite research contributions addressing the following themes:

  1. Epidemiology of antimicrobial and antiviral resistance;
  2. Viral infection in immunocompromised patients;
  3. Control and prevention of antimicrobial and antiviral resistance;
  4. Strategies of antimicrobial stewardship to combat antimicrobial and antiviral resistance;
  5. Advanced laboratory diagnostics of antimicrobial and antiviral resistance;
  6. Mechanism of antimicrobial resistance antiviral resistance.

Dr. Soyoun Shin
Dr. Alicia Galar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • infectious diseases
  • antimicrobial resistance
  • laboratory diagnostics

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

16 pages, 817 KiB  
Article
The Impact of Antibiotic Resistance in Childhood Campylobacter Infections Before and After the COVID-19 Pandemic in the Southeast Region of Romania
by Cristina Chiurtu, Elena Mocanu, Bogdan Florentin Nitu, Ana Maria Iancu, Cristina Maria Mihai, Mara Andreea Cambrea, Raluca Mihai, Mihaela Mavrodin, Anca Daniela Pînzaru and Ramona Mihaela Stoicescu
Antibiotics 2025, 14(2), 170; https://doi.org/10.3390/antibiotics14020170 - 10 Feb 2025
Viewed by 726
Abstract
The world has changed forever as a result of the COVID-19 pandemic. Antimicrobial resistance is a primary global health concern that places a significant financial and health burden on nations. Patients with Campylobacter-caused infections were the subject of the retrospective investigation. The data [...] Read more.
The world has changed forever as a result of the COVID-19 pandemic. Antimicrobial resistance is a primary global health concern that places a significant financial and health burden on nations. Patients with Campylobacter-caused infections were the subject of the retrospective investigation. The data show that children aged 1–6 are the most commonly affected by Campylobacter enteritis. Resistance levels fluctuated over the course of the two periods. Nine isolates were sensitive to macrolides, and only one was responsive to tetracycline, which indicated inadequate sensitivity across all classes throughout the pandemic. This pattern raises serious concerns about the potential impact on public health. Tetracyclines and fluoroquinolones rank highest in terms of bacterial resistance. Regardless of the species, macrolides remain a practical and sufficient treatment for Campylobacter enteritis. Reassurance is still provided by much lower numbers in the post-pandemic period. There is no evidence to support the alarming claims made in the international literature about macrolides in Romania. Full article
(This article belongs to the Special Issue Advancements in the Control and Diagnosis of Antimicrobial Resistance in Infectious Diseases)
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12 pages, 282 KiB  
Article
Detection of Chlamydia trachomatis and Neisseria gonorrhoeae (and Its Resistance to Ciprofloxacin): Validation of a Molecular Biology Tool for Rapid Diagnosis and Treatment
by María Paz Peris, Henar Alonso, Cristina Escolar, Alexander Tristancho-Baró, María Pilar Abad, Antonio Rezusta and Ana Milagro
Antibiotics 2024, 13(11), 1011; https://doi.org/10.3390/antibiotics13111011 - 28 Oct 2024
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Abstract
Background and Objectives: Neisseria gonorrhoeae and Chlamydia trachomatis can cause similar clinical syndromes and may coexist in infections. In emergency medicine, empirical treatment targeting both pathogens is often employed, potentially contributing to antibiotic resistance. Gonococcal resistance has emerged against first-line antimicrobials, necessitating [...] Read more.
Background and Objectives: Neisseria gonorrhoeae and Chlamydia trachomatis can cause similar clinical syndromes and may coexist in infections. In emergency medicine, empirical treatment targeting both pathogens is often employed, potentially contributing to antibiotic resistance. Gonococcal resistance has emerged against first-line antimicrobials, necessitating prior testing for fluoroquinolone susceptibility. Certest Biotec developed two molecular diagnostic products for simultaneous detection: VIASURE C. trachomatis & N. gonorrhoeae Real-Time PCR Detection Kit and VIASURE Neisseria gonorrhoeae Ciprofloxacin-Resistant Real-Time PCR Detection Kit. To evaluate these products, clinical performance assessments were conducted at the Clinical Microbiology Laboratory of Miguel Servet University Hospital in Zaragoza, Spain. Results and Conclusions: Both VIASURE assays under study demonstrated high clinical sensitivity and specificity compared to reference molecular assays and Sanger sequencing. These kits offer an accurate diagnosis, facilitating appropriate treatment choices while addressing concerns about emerging antibiotic resistance. Methods: A total of 540 clinical samples from 540 patients already characterized as positive or negative for CT and NG by a molecular assay and by antibiotic susceptibility testing for ciprofloxacin using a concentration gradient diffusion method were used for the clinical evaluation. In cases where sensitivity results were unavailable, conventional PCR and Sanger sequencing were employed. Full article
(This article belongs to the Special Issue Advancements in the Control and Diagnosis of Antimicrobial Resistance in Infectious Diseases)
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