Special Issue "Novel Advances in Aquaporin Water Channels in the Reproduction of Animals: Morpho-Functional Aspects"

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Physiology".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Alessandra Pelagalli
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Guest Editor
1. Department of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137 Naples, Italy
2. Institute of Biostructures and Bioimaging (IBB), National Research Council (CNR), 80131 Naples, Italy
Interests: MSCs from domestic animal species; MSCs physiology and behavior for translational regenerative medicine; migration and proliferation of MSCs and role of Aquaporin (AQPs); MSCs, conditioned medium and microenvironment in physiological condition
Special Issues, Collections and Topics in MDPI journals
Dr. Giovanna Liguori
E-Mail Website
Guest Editor
Department of Veterinary Medicine and Animal Productions, University of Napoli Federico II, 80100 Naples, Italy
Interests: immunofluorescence; immunohistochemistry; receptors; spermatogenesis; hypothalamus; testis
Prof. Nicola Mirabella
E-Mail Website
Guest Editor
Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80100 Naples, Italy
Interests: marine biology; cell biology; physiology
Dr. Caterina Squillacioti
E-Mail Website
Guest Editor
Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80100 Naples, Italy
Interests: PCR; western blot analysis; gene expression; immunofluorescence; immunohistochemistry; RNA isolation; molecular cell biology; protein expression; proteins; immunoprecipitation

Special Issue Information

Dear Colleagues,

Aquaporins (AQPs) are a family of transmembrane channel proteins widely distributed in humans and animals where they facilitate the transport of water and small solutes inside and outside the cells. The presence of several AQPs reported in different districts of male and female reproductive tract of animals suggests their important role in water homeostasis in order to ensure normal male and female fertility. It is well-known that AQPs can influence different reproductive processes, e.g., spermatogenesis, oocyte transport, estrous cycle and hormonal secretion, completion of successful fertilization, embryo development, pregnancy and birth. Moreover, the study of the AQPs involvement in the mechanisms regulating reproductive functions by sexual hormones or by other factors (nutritional, toxicants, metabolic and environmental conditions) interfering with normal reproductive function, is extremely interesting for functional approaches that should be applied to laboratory, small animals and livestock species.

These findings are confirmed in reproductive disorders and aging where alterations in the expression, function or regulation of AQPs are associated with different cellular and tissue dysfunctions. This Special Issue welcomes original research and review papers addressing innovative morpho-functional aspects of AQPs, including expression, function and regulation in biology and medicine as well as their translational value in pharmacology, in biotechnological and clinical approaches. In detail, the Issue focuses the attention on the functional role of AQPs on the health and fertility preservation of animals including biomedical and livestock species as well as a possible involvement of these proteins in Veterinary Clinician.

We invite you to share your recent findings through this Special Issue.

Prof. Dr. Alessandra Pelagalli
Dr. Giovanna Liguori
Prof. Nicola Mirabella
Dr. Caterina Squillacioti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aquaporins
  • reproductive tract
  • morphology
  • estrous cycle
  • animal physiology
  • hormones
  • spermatogenesis
  • aging
  • fertility dysfunction
  • laboratory animals
  • animals
  • livestock species

Published Papers (1 paper)

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Research

Article
Aquaporins Are Differentially Regulated in Canine Cryptorchid Efferent Ductules and Epididymis
Animals 2021, 11(6), 1539; https://doi.org/10.3390/ani11061539 - 25 May 2021
Cited by 1 | Viewed by 630
Abstract
The efferent ductules and the epididymis are parts of the male reproductive system where spermatozoa mature. Specialized epithelial cells in these ducts contribute to the transport of fluids produced by spermatozoa’s metabolic activity. Aquaporins (AQPs) have been demonstrated to be expressed in the [...] Read more.
The efferent ductules and the epididymis are parts of the male reproductive system where spermatozoa mature. Specialized epithelial cells in these ducts contribute to the transport of fluids produced by spermatozoa’s metabolic activity. Aquaporins (AQPs) have been demonstrated to be expressed in the spermatozoan membrane and testis epithelial cells, where they contribute to regulating spermatozoan volume and transit through environments of differing osmolality. Due to the lack of detailed literature regarding AQP expression in the canine male genital tract, the aim of this study was to investigate both the distribution and expression of AQP7, AQP8, and AQP9 in the efferent ductules and epididymal regions (caput, corpus, and cauda) from normal and cryptorchid dogs by using immunohistochemistry, Western blotting, and real-time reverse transcription polymerase chain reaction (RT-PCR). Our results show different patterns for the distribution and expression of the examined AQPs, with particular evidence of their upregulation in the caput and downregulation in the cauda region of the canine cryptorchid epididymis. These findings are associated with a modulation of Hsp70 and caspase-3 expression, suggesting the participation of AQPs in the luminal microenvironment modifications that are peculiar characteristics of this pathophysiological condition. Full article
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