2026 December - 13 articles
Justicia spicigera Schltdl. (Acanthaceae), commonly known as “muicle,” is a medicinal plant used in Mexico to treat diabetes, anemia, gastrointestinal disorders, inflammation, and infections. Its phytochemical composition and the biologic...
Cancer remains a significant global health challenge, underscoring the need for active therapeutic strategies that target the key molecular determinants of tumor progression. Naringenin, a flavonoid prevalent in the diet and abundant in citrus fruits...
Background/Objectives: In precision medicine, patient genetic data is increasingly being used to inform physicians’ prescribing of medication, yet current resources to access gene-drug interaction data are often difficult and unintuitive to use...
Introduction: The Mediterranean diet is consistently associated with a reduced risk of chronic diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions. These protective effects are largely attributed to its high intake...
Background: Gastrointestinal graft-versus-host disease (GI-GVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation. Conditioning directly injures the intestinal epithelium, whereas antibiotics, nutri...
Background: Lipid nanoparticle (LNP) systems have emerged as leading platforms for nucleic acid delivery, with high transfection, biocompatibility, and clinical success in RNA therapeutics. However, oral nucleic acid delivery remains a major challeng...
Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia, yet in children and adolescents it remains off-label and underused, constrained by safety concerns and scarce pediatric-specific evidence. Its benefits may extend be...
Background/Objectives: Cancer causes high premature death worldwide, with 35 million new cases expected by 2050. Multidrug resistance (MDR), driven by genetic and epigenetic changes, hampers chemotherapy. In this study, polymeric nanoparticles (NPs)...
Background/Objectives: Multidrug-resistant Salmonella enterica in poultry production poses a persistent challenge for antimicrobial stewardship and food safety. This study integrated phenotypic susceptibility testing, whole-genome sequencing, structu...
Oncolytic viruses (OVs) can selectively lyse tumor cells and remodel the immunosuppressive tumor microenvironment. However, monotherapy is limited by low response rates, systemic delivery barriers and antiviral-mediated viral clearance. Combinatorial...
In many immune-mediated kidney diseases, tissue injury is driven by dysregulated B-cell immunity, with autoantibodies and complement acting as key effectors at the glomerulus. Corticosteroids and conventional immunosuppressants control these diseases...
Nanocarrier platforms can improve cancer therapy through enhanced selectivity and reduced systemic toxicity. Yet mononuclear phagocyte system (MPS) clearance sharply limits delivery; in preclinical models, often less than 1% of the injected dose reac...
Cannabinoid signaling has attracted increasing interest in diabetes because the endocannabinoid system regulates energy balance, glucose and lipid metabolism, inflammation, and tissue homeostasis. However, its therapeutic relevance remains uncertain....
