2026 September - 18 articles
Background/Objectives: Microbial exopolysaccharides (EPS) are complex biopolymers that mimic the native extracellular matrix and have emerged as promising biomaterials for tissue regeneration. Methods: This study aimed to evaluate the therapeutic pot...
Background/Objectives: The objective of this study was to determine the secondary metabolites of the aqueous fraction of a methanolic extract of Salvia brandegeei root and their antimicrobial, antioxidant, anti-inflammatory and antinociceptive proper...
Background/Objectives: Non-medical use of GHB poses a public health risk due to the risk of overdose. GHB exhibits nonlinear toxicokinetics mediated by monocarboxylate transporters (MCTs), and previous studies have demonstrated sex-related difference...
Background: Due to drug efficacy, adverse reactions, and individual differences, clinicians face significant challenges in drug selection for the treatment of depression. However, the study on predicting antidepressant treatment response based on pha...
Background: The cerebellum integrates sensory information to maintain balance and posture, allowing movement guidance. Perinatal damage to this brain region correlates with an increased incidence of Autism Spectrum Disorder (ASD), a major neurodevelo...
Background: Rosuvastatin, a potent lipid-lowering statin, and curcumin, a bioactive naturally occurring polyphenolic phytochemical, both show pleiotropic antioxidant and anti-inflammatory properties. In addition, curcumin shows also antimicrobial, an...
Background/Objectives: Tryptophol and tyrosol are prominent secondary metabolites with diverse biological activities. Acetylation has been proposed as a strategy to modify the physicochemical properties of these compounds. Despite the proven neuropro...
Background/Objectives: Duloxetine is a serotonin–norepinephrine reuptake inhibitor used for psychiatric and chronic pain conditions. It enhances serotonergic and noradrenergic neurotransmission by inhibiting the reuptake of serotonin and norepi...
Background/Objectives: The pharmacological management of inflammation remains a clinical challenge, driving the demand for advanced topical formulations. This study utilizes a “smart-NADES” (natural deep eutectic solvent) paradigm to deve...
Background/Objectives. The use of antibiotic pastes in the Lesion Sterilization Tissue Repair (LSTR) technique has increased due to their ability to disinfect necrotic primary teeth without mechanical instrumentation. Tri-antibiotic mixtures (TAP) an...
Background: PRMT5, or protein arginine methyltransferase 5, is recognized as an epigenetic regulator that suppresses gene transcription through symmetric dimethylation of histone arginine residues, including histone H4 arginine 3 (H4R3me2s) and histo...
Background/Objectives: The non-neuronal cardiac cholinergic system (NNCCS) is known to synthesize ACh independently of the parasympathetic nervous system, thereby regulating cardiac homeostasis, which includes sustainability of energy metabolism, ant...
Background: The objective of this study was to evaluate the efficacy and safety of CAR-T immunotherapy in inducing remission in patients with Acute Lymphoblastic Leukemia (ALL). Methods: The search strategy was conducted in the BVS, Embase, PubMed, a...
Neurodegenerative diseases (NDs) such as Alzheimer’s, Parkinson’s, and Huntington’s disease are progressive and currently incurable conditions characterized by the deterioration of neuronal structure and function. Its incidence is i...
Xanthotoxin (8-methoxypsoralen) belongs to the group of naturally occurring furanocoumarin (furocoumarin) compounds and is a product of plant secondary metabolism. Analysis of the available literature indicates that xanthotoxin exhibits a broad spect...
Background: Prostate cancer remains one of the most prevalent malignancies worldwide, with high mortality in advanced and metastatic stages. Drug repurposing offers a cost-effective and time-efficient strategy to identify new therapeutic options. Obj...
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Background/Objectives: In this study, we present an analysis of ayahuasca, a psychedelic preparation containing N,N-dimethyltryptamine (DMT) and β-carbolines, such as harmine (HRM), a reversible monoamine oxidase A (MAO-A) inhibitor that enables...
