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BioTech, Volume 13, Issue 3

2024 September - 17 articles

Cover Story: This study applied machine learning (ML) to predict the disease severity in 344 unvaccinated patients with confirmed COVID-19, aiming to explain the differences in disease outcomes. By integrating the demographic and clinical data from questionnaires and medical records, various ML algorithms were applied to select the model with the highest predictive accuracy for a web-based prognostic tool. Of the 111 factors analyzed, age, sex, hypertension, obesity, and cancer comorbidities were significantly associated with severe COVID-19 outcomes. This tool supports personalized treatment strategies and encourages vaccination for vulnerable groups, although vaccination was not mandatory at the time of the study. The findings highlight ML’s potential in COVID-19 prognosis and improving therapeutic approaches. View this paper
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Articles (17)

  • Article
  • Open Access
3 Citations
3,404 Views
18 Pages

23 September 2024

Viruses and viroids pose a significant challenge in citriculture, and their control is crucial for plant health. This study evaluated the effectiveness of in vitro thermotherapy combined with a meristem tip culture for eliminating citrus exocortis vi...

  • Article
  • Open Access
1 Citations
3,473 Views
13 Pages

Clinical Evaluation of AMNIODERM+® Wound Dressing Containing Non-Viable Human Amniotic Membrane: Retrospective-Perspective Clinical Trial

  • Iveta Schmiedova,
  • Petr Slama,
  • Alena Dembickaja,
  • Beata Kozova,
  • Vendula Hyneckova,
  • Sona Gogolkova,
  • Elen Stastna,
  • Michal Zahradnicek,
  • Stefan Savic and
  • Emil Martinka
  • + 2 authors

19 September 2024

Chronic wounds result from the body’s inability to heal, causing pain, pathogen entry, limited treatment options, and societal burden. Diabetic foot ulcers are particularly challenging, often leading to severe complications like leg amputation....

  • Article
  • Open Access
6 Citations
2,945 Views
14 Pages

Simultaneous Production of Biogas and Electricity from Anaerobic Digestion of Pine Needles: Sustainable Energy and Waste Management

  • Deepak Sharma,
  • Rishi Mahajan,
  • Vikas Baghel,
  • Saurabh Bansal,
  • Vishal Ahuja and
  • Gunjan Goel

5 September 2024

Power scarcity and pollution can be overcome with the use of green energy forms like ethanol, biogas, electricity, hydrogen, etc., especially energy produced from renewable and industrial feedstocks. In hilly areas, pine needles are the most abundant...

  • Review
  • Open Access
37 Citations
10,161 Views
27 Pages

2 September 2024

Biobanking plays a pivotal role in biomedical research by providing standardized processing, precise storing, and management of biological sample collections along with the associated data. Effective data management is a prerequisite to ensure the in...

  • Article
  • Open Access
2,042 Views
16 Pages

1 September 2024

This study introduces the intelligent learning engine (ILE) optimization technology, a novel approach designed to revolutionize screening processes in bioinformatics, cheminformatics, and a range of other scientific fields. By focusing on the efficie...

  • Article
  • Open Access
7 Citations
4,210 Views
14 Pages

21 August 2024

Seven auxin-producing endophytic bacterial strains (Azospirillum spp., Methylobacterium symbioticum, Bacillus spp.), and two different combinations of these strains were used to verify their influence on tomato during germination and development in h...

  • Article
  • Open Access
2 Citations
8,237 Views
14 Pages

Principle Investigation and Method Standardization of Inhibition Zone Assay Based on Antimicrobial Peptides Extracted from Black Soldier Fly Larvae

  • Wenyue Shen,
  • Ranxia Xue,
  • Yanxia Liu,
  • Shibo Sun,
  • Xi Chen,
  • Dongye Sun,
  • Han Ouyang,
  • Yuxin Li,
  • Jianqiang Xu and
  • Weiping Xu
  • + 2 authors

9 August 2024

The black soldier fly is a valuable resource insect capable of transforming organic waste while producing antimicrobial peptides (AMPs). The inhibition zone assay (IZA) is a method used to demonstrate the antimicrobial activity of AMPs. This study ai...

  • Article
  • Open Access
2 Citations
5,589 Views
22 Pages

CleanUpRNAseq: An R/Bioconductor Package for Detecting and Correcting DNA Contamination in RNA-Seq Data

  • Haibo Liu,
  • Kai Hu,
  • Kevin O’Connor,
  • Michelle A. Kelliher and
  • Lihua Julie Zhu

3 August 2024

RNA sequencing (RNA-seq) has become a standard method for profiling gene expression, yet genomic DNA (gDNA) contamination carried over to the sequencing library poses a significant challenge to data integrity. Detecting and correcting this contaminat...

  • Article
  • Open Access
2 Citations
5,574 Views
14 Pages

Molecular Insight into the Response of Lactic Acid Bacteria to Bile Acids

  • Caren N. Moreno,
  • Jorge N. Gomez,
  • María P. Taranto,
  • Ana E. Ledesma and
  • Ana Y. Bustos

2 August 2024

Bile acids (BAs) are the main endogenous modulators of the composition and metabolic activity of the intestinal microbiota. In the present work, the effect of conjugated (glycodeoxycholic, glycocholic, taurodeoxycholic, taurocholic acids) and free BA...

  • Article
  • Open Access
5 Citations
2,565 Views
14 Pages

Removal of Cadmium (II) from Aqueous Solution Using Galdieria sulphuraria CCMEE 5587.1

  • Hari Lal Kharel,
  • Lina Jha,
  • Melissa Tan and
  • Thinesh Selvaratnam

1 August 2024

The release of cadmium into the environment is a significant global concern due to its toxicity, non-biodegradability, and persistence in nature. There is an urgent need for effective, eco-friendly, and cost-effective systems for removing Cd because...

  • Feature Paper
  • Review
  • Open Access
22 Citations
7,707 Views
31 Pages

Hydroponics with Microalgae and Cyanobacteria: Emerging Trends and Opportunities in Modern Agriculture

  • Prabhaharan Renganathan,
  • Edgar Omar Rueda Puente,
  • Natalia V. Sukhanova and
  • Lira A. Gaysina

22 July 2024

The global population is expected to reach 9.5 billion, which means that crop productivity needs to double to meet the growing population’s food demand. Soil degradation and environmental factors, such as climate events, significantly threaten...

  • Article
  • Open Access
2,276 Views
14 Pages

Strategies for Increasing the Throughput of Genetic Screening: Lessons Learned from the COVID-19 Pandemic within a University Community

  • Fernanda Miguel,
  • A. Raquel Baleizão,
  • A. Gabriela Gomes,
  • Helena Caria,
  • Fátima N. Serralha and
  • Marta C. Justino

11 July 2024

Amidst the COVID-19 pandemic, the Polytechnic University of Setúbal (IPS) used its expertise in molecular genetics to establish a COVID-19 laboratory, addressing the demand for community-wide testing. Following standard protocols, the IPS COVI...

  • Article
  • Open Access
2,149 Views
14 Pages

An Efficient and Rapid Protocol for Somatic Shoot Organogenesis from Juvenile Hypocotyl-Derived Callus of Castor Bean cv. Zanzibar Green

  • Danaya V. Demidenko,
  • Nataliya V. Varlamova,
  • Taisiya M. Soboleva,
  • Aleksandra V. Shitikova and
  • Marat R. Khaliluev

Aseptic seedlings of different ages derived from surface-sterilized mature seeds were applied as an explant source. Various explants such as 7- and 21-day-old hypocotyl fragments, 42-day-old nodal stem segments, and transverse nodal segments of stem,...

  • Article
  • Open Access
1 Citations
2,768 Views
13 Pages

Rutin, a flavonoid phytochemical compound, plays a vital role in human health. It is used in treating capillary fragility and has anti-Alzheimer, anti-inflammatory, and antioxidant effects. In this study, Ti-Mo-Ni-O nanotubes (NTs) were used, for the...

  • Article
  • Open Access
1,979 Views
15 Pages

Systemic Effects of Photoactivated 5,10,15,20-tetrakis(N-methylpyridinium-3-yl) Porphyrin on Healthy Drosophila melanogaster

  • Ana Filošević Vujnović,
  • Sara Čabrijan,
  • Martina Mušković,
  • Nela Malatesti and
  • Rozi Andretić Waldowski

Porphyrins are frequently employed in photodynamic therapy (PDT), a non-invasive technique primarily utilized to treat subcutaneous cancers, as photosensitizing agents (PAs). The development of a new PA with improved tissue selectivity and efficacy i...

  • Article
  • Open Access
4 Citations
3,604 Views
14 Pages

A Machine Learning-Based Web Tool for the Severity Prediction of COVID-19

  • Avgi Christodoulou,
  • Martha-Spyridoula Katsarou,
  • Christina Emmanouil,
  • Marios Gavrielatos,
  • Dimitrios Georgiou,
  • Annia Tsolakou,
  • Maria Papasavva,
  • Vasiliki Economou,
  • Vasiliki Nanou and
  • Nikolaos Drakoulis
  • + 7 authors

Predictive tools provide a unique opportunity to explain the observed differences in outcome between patients of the COVID-19 pandemic. The aim of this study was to associate individual demographic and clinical characteristics with disease severity i...

  • Article
  • Open Access
3 Citations
2,085 Views
12 Pages

Influence of Critical Parameters on the Extraction of Concentrated C-PE from Thermotolerant Cyanobacteria

  • Ariadna H. Vergel-Suarez,
  • Janet B. García-Martínez,
  • German L. López-Barrera,
  • Néstor A. Urbina-Suarez and
  • Andrés F. Barajas-Solano

24 June 2024

This work aimed to identify the influence of pH, molarity, w/v fraction, extraction time, agitation, and either a sodium (Na2HPO4·7H2O-NaH2PO4·H2O) or potassium buffer (K2HPO4-KH2PO4) used in the extraction of C-phycoerythrin (C-PE) fro...

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BioTech - ISSN 2673-6284