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Tropical Medicine and Infectious Disease, Volume 9, Issue 9

2024 September - 35 articles

Cover Story: Clinicians in resource-limited settings increasingly rely upon point-of-care testing (PoCT) to assess and manage critically ill patients. However, the clinical utility of many PoCT types in the care of children with cerebral malaria (CM) remains unknown. We assessed the frequency of abnormal PoCT results for glucose, lactate, creatinine, electrolytes, and blood gases; the clinical interventions performed in response to these abnormalities; and their association with patient outcomes among 193 Malawian children with CM. We found that the abnormal PoCT results were not often followed by interventions despite the high frequency with which they occurred and their association with poor outcomes. Further investigations are needed to determine whether children with CM would benefit from specific clinical interventions targeting these abnormal results. View this paper
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Articles (35)

  • Case Report
  • Open Access
2 Citations
2,214 Views
5 Pages

Think Vibrio, Think Rare: Non-O1-Non-O139- Vibrio cholerae Bacteremia in Advanced Lung Cancer—A Case Report

  • Andrea Marino,
  • Bruno Cacopardo,
  • Laura Villa,
  • Adriana D’Emilio,
  • Salvatore Piro and
  • Giuseppe Nunnari

Vibrio cholerae, a Gram-negative bacterium, is widely known as the cause of cholera, an acute diarrheal disease. While only certain strains are capable of causing cholera, non-O1/non-O139 V. cholerae strains (NOVC) can lead to non-pathogenic coloniza...

  • Review
  • Open Access
21 Citations
15,038 Views
12 Pages

Antimalarial Mechanisms and Resistance Status of Artemisinin and Its Derivatives

  • Dan Zheng,
  • Tingting Liu,
  • Shasha Yu,
  • Zhilong Liu,
  • Jing Wang and
  • Ying Wang

Artemisinin is an endoperoxide sesquiterpene lactone isolated from Artemisia annua and is often used to treat malaria. Artemisinin’s peroxide bridge is the key structure behind its antimalarial action. Scientists have created dihydroartemisinin...

  • Review
  • Open Access
15 Citations
7,678 Views
20 Pages

WHO promotes the implementation of a comprehensive strategy to control and eliminate schistosomiasis through preventive chemotherapy, snail control, clean water supply, improved sanitation, behaviour change interventions, and environmental management...

  • Review
  • Open Access
1 Citations
3,546 Views
14 Pages

Schistosomiasis in the Military—A Narrative Review

  • Diana Isabela Costescu Strachinaru,
  • Jemima Nyaboke Nyandwaro,
  • Anke Stoefs,
  • Eric Dooms,
  • Peter Vanbrabant,
  • Pierre-Michel François,
  • Mihai Strachinaru,
  • Marjan Van Esbroeck,
  • Emmanuel Bottieau and
  • Patrick Soentjens

Schistosomiasis is a parasitosis caused by trematodes of the genus Schistosoma. Humans are infected when coming into contact with freshwater containing the parasites’ infective stages, which are amplified through freshwater-dwelling snails acti...

  • Article
  • Open Access
3,269 Views
18 Pages

People Who Self-Reported Testing HIV-Positive but Tested HIV-Negative: A Multi-Country Puzzle of Data, Serology, and Ethics, 2015–2021

  • Melissa Metz,
  • Vivian Hope Among,
  • Tafadzwa Dzinamarira,
  • Faith Ussery,
  • Peter Nkurunziza,
  • Janet Bahizi,
  • Samuel Biraro,
  • Francis M. Ogollah,
  • Joshua Musinguzi and
  • Shannon M. Farley
  • + 12 authors

During population-based HIV impact assessments (PHIAs), some participants who self-reported testing HIV-positive (PSRP) tested negative in one or more subsequent survey HIV tests. These unexpected discrepancies between their self-reported results and...

  • Systematic Review
  • Open Access
1,676 Views
17 Pages

Evaluation of Chemokines MIG and IP-10 as Immunological Biomarkers of Human Visceral Leishmaniasis: A Systematic Review

  • Bruna Eduarda Freitas Monteiro,
  • Elis Dionísio da Silva,
  • Walter Lins Barbosa Júnior,
  • Amanda Virginia Batista Vieira,
  • Roberta dos Santos Souza,
  • Maria Karollyne dos Santos Paiva,
  • Pablo Cantalice Santos Farias,
  • Diego Lins Guedes,
  • Gilberto Silva Nunes Bezerra and
  • Zulma Maria de Medeiros

Visceral leishmaniasis (VL) is a neglected tropical disease that is potentially fatal when untreated. Current diagnostic methods have limitations that contribute to ongoing transmission and poor prognosis. Thus, new tests are needed to provide quick,...

  • Article
  • Open Access
11 Citations
4,995 Views
11 Pages

Tolerability and Safety of Miltefosine for the Treatment of Cutaneous Leishmaniasis

  • Nadav Astman,
  • Chen Arbel,
  • Oren Katz,
  • Aviv Barzilai,
  • Michal Solomon and
  • Eli Schwartz

Miltefosine, an orally administered drug, is an important component of the therapeutic arsenal against visceral and mucosal forms of leishmaniasis. However, data regarding the safety and tolerability of miltefosine treatment for cutaneous leishmanias...

  • Article
  • Open Access
5 Citations
4,619 Views
21 Pages

Multidrug-Resistant Proteus mirabilis and Other Gram-Negative Species Isolated from Native Egyptian Chicken Carcasses

  • Bassant Ashraf El-Saeed,
  • Hend Ali Elshebrawy,
  • Amira Ibrahim Zakaria,
  • Adel Abdelkhalek,
  • Kálmán Imre,
  • Adriana Morar,
  • Viorel Herman and
  • Khalid Ibrahim Sallam

Poultry carcasses may be reservoirs for the zoonotic transmission of antimicrobial-resistant bacteria to humans and pose a major public health hazard. During the isolation of Salmonella from poultry and other foods, many of the presumptive typical Sa...

  • Article
  • Open Access
10 Citations
5,764 Views
23 Pages

Enhancing the Interpretability of Malaria and Typhoid Diagnosis with Explainable AI and Large Language Models

  • Kingsley Attai,
  • Moses Ekpenyong,
  • Constance Amannah,
  • Daniel Asuquo,
  • Peterben Ajuga,
  • Okure Obot,
  • Ekemini Johnson,
  • Anietie John,
  • Omosivie Maduka and
  • Faith-Michael Uzoka
  • + 1 author

Malaria and Typhoid fever are prevalent diseases in tropical regions, and both are exacerbated by unclear protocols, drug resistance, and environmental factors. Prompt and accurate diagnosis is crucial to improve accessibility and reduce mortality ra...

  • Brief Report
  • Open Access
2 Citations
2,180 Views
7 Pages

Murine Extraparenchymal Neurocysticercosis: Appropriate Model for Evaluating Anthelminthic and Anti-Inflammatory Treatment Schedules

  • Vinícius Tadeu Oliveira,
  • Tatiane de Camargo Martins,
  • Renato Tavares Conceição,
  • Diego Generoso,
  • Vânia Maria de Vasconcelos Machado,
  • Sabrina Setembre Batah,
  • Alexandre Todorovic Fabro,
  • Marco Antônio Zanini,
  • Edda Sciutto and
  • Pedro Tadao Hamamoto Filho
  • + 1 author

Background: Experimental models of neurocysticercosis (NCC) are helpful for an improved understanding of the pathophysiological mechanisms of human diseases and for testing novel therapeutic approaches. Controlling inflammation without reducing the e...

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Trop. Med. Infect. Dis. - ISSN 2414-6366