Beyond Borders—Tackling Neglected Tropical Viral Diseases

Special Issue Editor

Special Issue Information

Dear Colleagues,

Neglected tropical diseases (NTDs) encompass a diverse group of conditions that disproportionately affect populations living in poverty, primarily in tropical and subtropical regions. Among these NTDs, viral infections play a significant role, causing devastating health, social, and economic consequences.

This Special Issue aims to explore innovative strategies, research, and collaborative efforts specifically focused on neglected tropical viral diseases.

We invite contributions that delve into neglected tropical viral diseases (dengue, Zika, chikungunya, yellow fever, and other related infections).

We invite submissions that aim to do the following:

  • Explore the epidemiology of neglected tropical viral diseases and emphasize cross-border collaboration;
  • Share advancements in diagnostic tools, antiviral therapies, and vaccine development;
  • Discuss vector-borne viral NTDs and effective approaches to control mosquito populations;
  • Highlight community-based programs that raise awareness, promote preventive measures, and empower local populations;
  • Explore the impact of climate variability on disease transmission and adaptation strategies;
  • Share successful examples of international collaboration in tackling viral NTDs.

By transcending borders and fostering collaboration, we can accelerate progress in tackling neglected tropical viral diseases. This Special Issue aims to contribute to a world where no one suffers needlessly due to preventable infections.

Dr. Jelena Prpić
Guest Editor

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Keywords

  • dengue
  • Zika
  • chikungunya 
  • yellow fever 
  • antiviral therapies 
  • vector control 
  • viral NTDs 
  • transmission and epidemiology

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Published Papers (2 papers)

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Research

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6 pages, 383 KiB  
Communication
Factors Contributing to In-Hospital Mortality in Dengue: Insights from National Surveillance Data in Mexico (2020–2024)
by Eder Fernando Ríos-Bracamontes, Oliver Mendoza-Cano, Agustin Lugo-Radillo, Ana Daniela Ortega-Ramírez and Efrén Murillo-Zamora
Trop. Med. Infect. Dis. 2024, 9(9), 202; https://doi.org/10.3390/tropicalmed9090202 - 3 Sep 2024
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Abstract
This study aimed to identify the factors associated with all-cause in-hospital mortality in laboratory-confirmed dengue cases from 2020 to mid-2024. A nationwide retrospective cohort study was conducted in Mexico and data from 18,436 participants were analyzed. Risk ratios (RRs) and 95% confidence intervals [...] Read more.
This study aimed to identify the factors associated with all-cause in-hospital mortality in laboratory-confirmed dengue cases from 2020 to mid-2024. A nationwide retrospective cohort study was conducted in Mexico and data from 18,436 participants were analyzed. Risk ratios (RRs) and 95% confidence intervals (CIs), estimated using generalized linear regression models, were used to evaluate the factors associated with all-cause in-hospital mortality risk. The overall case–fatality rate was 17.5 per 1000. In the multiple model, compared to dengue virus (DENV) 1 infections, DENV-2 (RR = 1.81, 95% CI 1.15–2.86) and DENV-3 (RR = 1.87, 95% CI 1.19–2.92) were associated with increased mortality risk. Patient characteristics, such as increasing age (RR = 1.02, 95% CI 1.01–1.03), type 2 diabetes mellitus (RR = 2.07, 95% CI 1.45–2.96), and chronic kidney disease (RR = 3.35, 95% CI 2.03–5.51), were also associated with an increased risk of a fatal outcome. We documented the influence of both the virus and individual susceptibility on mortality risk, underscoring the need for a comprehensive public health strategy for dengue. Full article
(This article belongs to the Special Issue Beyond Borders—Tackling Neglected Tropical Viral Diseases)
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Review

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27 pages, 1625 KiB  
Review
Suppression of Interferon Response and Antiviral Strategies of Bunyaviruses
by Yingying He, Min Shen, Xiaohe Wang, Anqi Yin, Bingyan Liu, Jie Zhu and Zhenhua Zhang
Trop. Med. Infect. Dis. 2024, 9(9), 205; https://doi.org/10.3390/tropicalmed9090205 - 7 Sep 2024
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Abstract
The order Bunyavirales belongs to the class of Ellioviricetes and is classified into fourteen families. Some species of the order Bunyavirales pose potential threats to human health. The continuously increasing research reveals that various viruses within this order achieve immune evasion in the [...] Read more.
The order Bunyavirales belongs to the class of Ellioviricetes and is classified into fourteen families. Some species of the order Bunyavirales pose potential threats to human health. The continuously increasing research reveals that various viruses within this order achieve immune evasion in the host through suppressing interferon (IFN) response. As the types and nodes of the interferon response pathway are continually updated or enriched, the IFN suppression mechanisms and target points of different virus species within this order are also constantly enriched and exhibit variations. For instance, Puumala virus (PUUV) and Tula virus (TULV) can inhibit IFN response through their functional NSs inhibiting downstream factor IRF3 activity. Nevertheless, the IFN suppression mechanisms of Dabie bandavirus (DBV) and Guertu virus (GTV) are mostly mediated by viral inclusion bodies (IBs) or filamentous structures (FSs). Currently, there are no effective drugs against several viruses belonging to this order that pose significant threats to society and human health. While the discovery, development, and application of antiviral drugs constitute a lengthy process, our focus on key targets in the IFN response suppression process of the virus leads to potential antiviral strategies, which provide references for both basic research and practical applications. Full article
(This article belongs to the Special Issue Beyond Borders—Tackling Neglected Tropical Viral Diseases)
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