HIV Testing, Prevention and Care Interventions

A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366).

Deadline for manuscript submissions: 31 July 2024 | Viewed by 4209

Special Issue Editors


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Guest Editor
Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Quito, Ecuador
Interests: HIV testing; HIV treatment; pharmacology; infectious diseases; global health; neglected diseases; pharmacogenetics

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Guest Editor
College of Public Health, University of South Florida, Tampa, FL 33612, USA
Interests: HIV testing; HIV epidemiology; infectious diseases; global health; neglected diseases; virology
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Special Issue Information

Dear Colleagues,

Infection by human immunodeficiency virus (HIV) is a growing problem all around the world that, if not diagnosed and treated early, might cause acquired immunodeficiency syndrome (AIDS), the most advanced stage of HIV infection. Worldwide strategy promoted by the World Health Organization (WHO) and the United Nations UNAIDS focuses on 95% of people living with HIV knowing their status, 95% of people diagnosed with HIV being on antiretroviral therapy, and 95% of people on ART achieving viral suppression. It is well known that risk factors for HIV include having vaginal or anal sex with someone who is HIV positive or whose HIV status you do not know; having sex with many partners; and injecting drugs and sharing needles, syringes, or other drug equipment with others. For example, the Centers for Disease Control and Prevention (CDC) in the US recommends that everyone 13 to 64 years of age get tested for HIV at least once as part of routine health care and that people at higher risk for HIV get tested more often. If you are over 64 years of age and at risk for HIV, your health care provider may recommend HIV testing. Additionally, the CDC recommends that all pregnant women get tested for HIV so that they can begin taking HIV medicines if they are HIV positive. In addition, to achieve viral suppression, it is crucial to the laboratory monitoring of this parameter in the person living with HIV.

However, full access to testing is not possible everywhere, not necessarily due to lack of resources, as there are legal, cultural, and even religious barriers, plus the stigma, of course. For those reasons, this Special Issue is primarily focused on sharing experiences and pitfalls in one’s own reality to overcome HIV testing barriers, and those strategies to set proper prevention and care interventions.

In addition, this Special Issue aims to be enriched with quantitative data, rather than descriptive studies, to provide additional tools for decision makers on the important public health aspects concerning HIV-infected people, particularly to ensure that HIV is completely controlled and improve awareness in the HIV-negative population.

Prof. Dr. Enrique Terán
Dr. Ricardo Izurieta
Guest Editors

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Keywords

  • HIV testing
  • HIV stigma
  • HIV prevention
  • HIV care

Published Papers (2 papers)

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Research

12 pages, 394 KiB  
Article
Risk Screening Tools Could Potentially Miss HIV-Positive Individuals Who Seek Testing Services: A Secondary Program Data Analysis on the Performance Characteristics of an Adolescent and Adult HIV Risk Screening Tool in Uganda
by Marvin Lubega, Katherine Guerra, Megan Ginivan, Yewande Kamuntu, George Senyama, Andrew Musoke, Fiona Gambanga, Shaukat Khan, Geoffrey Taasi, Sylivia Nalubega and John Bosco Junior Matovu
Trop. Med. Infect. Dis. 2024, 9(2), 37; https://doi.org/10.3390/tropicalmed9020037 - 01 Feb 2024
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Abstract
Improving HIV testing efficiency saves financial and material resources for health. We conducted a secondary data analysis of routinely collected HIV risk-screening program data in Uganda, from October to November 2019, to determine the performance characteristics of the adolescent and adult HIV risk [...] Read more.
Improving HIV testing efficiency saves financial and material resources for health. We conducted a secondary data analysis of routinely collected HIV risk-screening program data in Uganda, from October to November 2019, to determine the performance characteristics of the adolescent and adult HIV risk screening tools in public health facilities. A total of 19,854 clients had been screened for HIV testing eligibility and tested for HIV. The overall positivity rate (cluster-weighted prevalence of HIV) among those screened was 4.5% (95% CI: 4.1–4.8) versus 3.71% (95% CI: 3.06–4.50) among those not screened. The sensitivity and specificity of the risk screening tool were 91% (95% CI: 89–93) and 25% (24.2–26), respectively. With screening, the number needed to test to identify one PLHIV was reduced from 27 to 22. Although risk screening would have led to a 24.5% (4825/19,704) reduction in testing volume, 9.3% (68/732) of PLHIV would have been missed and be misclassified as not eligible for testing. The cost saving per PLHIV identified was minimally reduced by 3% from USD 69 without screening to USD 66.9 with screening. Since the treatment-adjusted prevalence of HIV is dropping globally, overzealous use of risk screening tools to determine who to test or not carries the potential of missing PLHIV due to their limited specificity. We recommend the use of scientifically validated HIV risk screening tools, and a need to explore the use of HIV self-testing as a test for tirage to minimize misclassification of people who seek HIV testing services. Full article
(This article belongs to the Special Issue HIV Testing, Prevention and Care Interventions)
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13 pages, 6748 KiB  
Article
Patterns of Rising HIV Positivity in Northern Madagascar: Evidence of an Urgent Public Health Concern
by Kyle E. Robinson, Jackson K. Long, Mamantsara Fardine, Adriantiana M. Stephano, Andrew Walsh and Eric P. Grewal
Trop. Med. Infect. Dis. 2024, 9(1), 19; https://doi.org/10.3390/tropicalmed9010019 - 11 Jan 2024
Cited by 1 | Viewed by 1690
Abstract
Despite over two decades of progress against HIV/AIDS in adjacent sub-Saharan Africa, HIV rates and deaths due to AIDS are exponentially rising in Madagascar. Furthermore, a growing body of evidence suggests that, due to a scarcity of general-population screening data, even the startling [...] Read more.
Despite over two decades of progress against HIV/AIDS in adjacent sub-Saharan Africa, HIV rates and deaths due to AIDS are exponentially rising in Madagascar. Furthermore, a growing body of evidence suggests that, due to a scarcity of general-population screening data, even the startling increase demonstrated by official models vastly underestimates the true population prevalence of HIV. We aimed to implement a real-world HIV screening and treatment protocol to serve a general population stemming from across northern Madagascar. In collaboration with the Malagasy Ministry of Health, we provided point-of-care HIV screening and confirmatory testing for over 1000 participants from 73 towns, villages, and cities. We recorded an overall HIV prevalence of 2.94%. Notably, we observed a 13.1% HIV prevalence rate among urban populations and showed that proximity to a major route of travel was significantly associated with HIV risk. We also observed a link between HIV risk and various occupations, including those associated with increased mobility (such as mining). Importantly, all HIV-positive individuals were initiated on antiretroviral therapy in concordance with local health authorities. To our knowledge, this study marks the largest primary test data-based HIV study to date among Madagascar’s general population, showing a greatly higher HIV prevalence (2.9%) than previously reported modeling-based figures (0.4%). Our rates aligned with the pattern of higher prevalence demonstrated in smaller general-population screening studies occurring more commonly prior to political strife in the mid-2000s. These findings demonstrate evidence of a growing HIV epidemic in northern Madagascar and underscore the need for future investment into more comprehensive HIV screening and control initiatives in Madagascar. Full article
(This article belongs to the Special Issue HIV Testing, Prevention and Care Interventions)
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