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Sci, Volume 5, Issue 4

December 2023 - 10 articles

Cover Story: Chronic inflammation is associated with cancer, as it promotes the growth of tumors through proangiogenic factors. These factors are initiated by polarized leukocytes, which rely on the TIPE2 protein for their mobility. Inhibiting TIPE2 could offer a therapeutic approach for solid tumor cancers, but no inhibitors have been developed due to the protein's large cavity size. Researchers used structure-based and fragment-based drug design methods to identify potential small molecule inhibitors. Through computational screening, three hit compounds were discovered, including C2-F14, which demonstrated strong binding affinity and promising properties for further development. View this paper
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Articles (10)

  • Review
  • Open Access
39 Citations
22,046 Views
26 Pages

15 December 2023

In recent years, generative transformers have become increasingly prevalent in the field of artificial intelligence, especially within the scope of natural language processing. This paper provides a comprehensive overview of these models, beginning w...

  • Article
  • Open Access
7 Citations
6,062 Views
16 Pages

The Perceptions of Generation Z University Students about Their Futures: A Qualitative Study

  • Gül Dikeç,
  • Simge Öztürk,
  • Neslihan Taşbaşı,
  • Damla Figenergül and
  • Bilal Buğrahan Güler

8 December 2023

This study explored the future-oriented perceptions of Generation Z students in a foundation university. This study was conducted using qualitative research and a phenomenological design. The study sample consisted of 11 university students over the...

  • Review
  • Open Access
10 Citations
4,005 Views
19 Pages

Cooperating and Competing Digital Twins for Industrie 4.0 in Urban Planning Contexts

  • Otthein Herzog,
  • Matthias Jarke and
  • Siegfried Zhiqiang Wu

28 November 2023

Digital twins are emerging as a prime analysis, prediction, and control concepts for enabling the Industrie 4.0 vision of cyber-physical production systems (CPPSs). Today’s growing complexity and volatility cannot be handled by monolithic digit...

  • Article
  • Open Access
4 Citations
3,486 Views
14 Pages

Changes in Anthropometric Characteristics and Isokinetic Muscle Strength in Elite Team Sport Players during an Annual Training Cycle

  • Evangelia Papaevangelou,
  • Zacharoula Papadopoulou,
  • Athanasios Mandroukas,
  • Yiannis Michaildis,
  • Pantelis T. Nikolaidis,
  • Nikos V. Margaritelis and
  • Thomas I. Metaxas

23 November 2023

The aim of the present research was to investigate the variation in the anthropometric characteristics and the isokinetic muscle strength of elite female team sport players during a season (29–36 weeks). Three groups of female athletes that consisted...

  • Article
  • Open Access
8 Citations
4,059 Views
15 Pages

Development of Tannic Acid Coated Polyvinylidene Fluoride Membrane for Filtration of River Water Containing High Natural Organic Matter

  • Rosmaya Dewi,
  • Norazanita Shamsuddin,
  • Muhammad Saifullah Abu Bakar,
  • Sutarat Thongratkaew,
  • Kajornsak Faungnawakij and
  • Muhammad Roil Bilad

20 November 2023

River water can be used as a source of drinking water. However, it is vital to consider the existence of natural organic matter (NOM) and its possible influence on water quality (low turbidity, high color). The level of NOM in river water significant...

  • Review
  • Open Access
41 Citations
21,208 Views
16 Pages

30 October 2023

Blockchain offers a cutting-edge solution for storing medical data, carrying out medical transactions, and establishing trust for medical data integration and exchange in a decentralized open healthcare network setting. While blockchain in healthcare...

  • Concept Paper
  • Open Access
25 Citations
6,464 Views
16 Pages

Digital Twins in Manufacturing: A RAMI 4.0 Compliant Concept

  • Martin Lindner,
  • Lukas Bank,
  • Johannes Schilp and
  • Matthias Weigold

10 October 2023

Digital twins are among the technologies that are considered to have high potential. At the same time, there is no uniform understanding of what this technology means. Definitions are used across disciplinary boundaries, resulting in a multitude of d...

  • Article
  • Open Access
3,164 Views
14 Pages

In Silico Study of Potential Small Molecule TIPE2 Inhibitors for the Treatment of Cancer

  • Jerica Wilson,
  • Katerina Evangelou,
  • Youhai H. Chen and
  • Hai-Feng Ji

7 October 2023

Context: Chronic inflammation has been linked to cancer since the 19th century. Tumor growth is supported by the proangiogenic factors that chronic inflammation requires. Polarized leukocytes initiate these angiogenic and tumorigenic factors. TIPE2,...

  • Article
  • Open Access
2 Citations
5,997 Views
21 Pages

26 September 2023

The aim of this research is to present the effects of acupuncture treatment on morning blood glucose level (BGL) in type 2 diabetes mellitus (T2DM) patients, and to describe them by a predictive model. The morning BGL is measured after overnight fast...

  • Article
  • Open Access
9 Citations
3,566 Views
17 Pages

T5 for Hate Speech, Augmented Data, and Ensemble

  • Tosin Adewumi,
  • Sana Sabah Sabry,
  • Nosheen Abid,
  • Foteini Liwicki and
  • Marcus Liwicki

22 September 2023

We conduct relatively extensive investigations of automatic hate speech (HS) detection using different State-of-The-Art (SoTA) baselines across 11 subtasks spanning six different datasets. Our motivation is to determine which of the recent SoTA model...

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Sci - ISSN 2413-4155