Skip to Content

Tomography, Volume 12, Issue 5

2026 May - 17 articles

Cover Story: Radiation therapy (RT) plays a major role in treating early and locally advanced thoracic cancer. Although survival rates have increased due to the use of modern RT techniques and advances in treatments, RT-induced cardiac toxicity is still a major concern in these patients. Currently, it is unclear what cardiac substructure RT dose is safe, as a wide range of dose–volume parameters have been evaluated in the retrospective studies to date. Furthermore, current approaches for minimizing doses to organs at risk during RT planning use a one-model-fits-all approach, where a standard dose constraint is used to limit RT dose to the whole heart during treatment planning, regardless of baseline risk factor burden or the presumed diversity of relative radiation sensitivity among the cardiac substructures, which is investigated in this pilot study. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (17)

  • Article
  • Open Access
616 Views
13 Pages

Myocardial T2 Star (T2*) in a Large Healthy Population: Correction Factors for a Segmental Approach Using Commercially Available Software in the Current MRI Era

  • Amalia Lupi,
  • Sebastiano Gambato,
  • Ambra Checchetto,
  • Stefania Zinato,
  • Sophie Mavrogeni,
  • Filippo Crimì,
  • Marco Castellaro,
  • Emilio Quaia and
  • Alessia Pepe

Purpose: Myocardial iron overload has been demonstrated to have a heterogeneous distribution. A segmental T2* CMR approach, with correction factors applied to account for artifacts, has been demonstrated to be feasible and has permitted a reduction i...

(This article belongs to the Section Cardiovascular Imaging)
  • Article
  • Open Access
829 Views
34 Pages

Background/Objectives: Early and accurate prediction of pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) is vital for personalized breast cancer treatment. However, existing deep learning methods are hampered by tumor heterog...

  • Article
  • Open Access
749 Views
11 Pages

Radial Peripapillary Capillary Density Involved in Nasal Optic Disc Thinning and Visual Field Abnormalities Using Optical Coherence Tomography Angiography

  • Miki Yoshimura,
  • Yuki Hashimoto,
  • Yuko Kodama,
  • Aris Hatanaka,
  • Ryusei Yakushiji,
  • Shiho Ikeda,
  • Nazuna Inoue,
  • Maho Wakabayashi,
  • Ichika Kawazu and
  • Takeshi Yoshitomi

Objectives: This study investigated whether visual field abnormalities are present in eyes with suspected nasal optic disc hypoplasia (NOH) by using fundus photography and optical coherence tomography (OCT). Methods: NOH was diagnosed using the follo...

  • Article
  • Open Access
654 Views
14 Pages

Background: Cage subsidence (CS) is among the main complications after oblique lumbar interbody fusion (OLIF) and may lead to the failure of indirect decompression. Accurate preoperative bone quality assessment is critical for risk stratification, ye...

(This article belongs to the Special Issue Orthopaedic Radiology: Establishing Radiologic Measurements as Diagnostic Tools and Criteria for Treatment)
  • Article
  • Open Access
1 Citations
723 Views
14 Pages

Tensor-Valued Diffusion MRI for Microstructural Assessment During Stereotactic Radiotherapy of Brain Metastases: A Feasibility Study

  • Minna Lerner,
  • Patrik Brynolfsson,
  • Filip Szczepankiewicz,
  • Joakim Medin,
  • Pia C. Sundgren,
  • Lars E. Olsson and
  • Sara Alkner

Objectives: Early identification of treatment response in brain metastases remains clinically challenging. This study explores tensor-valued diffusion MRI (dMRI), specifically q-space trajectory imaging (QTI), as a novel source of early imaging bioma...

(This article belongs to the Special Issue Progress in the Use of Advanced Imaging for Radiation Oncology)
  • Article
  • Open Access
719 Views
13 Pages

Association Between Regional Cardiac Radiation Dose and Magnetic Resonance Imaging Myocardial Contractility Parameters: A Prospective Pilot Study

  • El-Sayed H. Ibrahim,
  • Slade Klawikowski,
  • Lindsay Puckett,
  • Elizabeth Gore,
  • Dayeong An,
  • Jakub Bychowski,
  • Antonio Sosa,
  • Gerard Walls and
  • Carmen Bergom

Background/Objectives: Magnetic resonance imaging (MRI) provides a non-invasive means for a comprehensive assessment of the effect of radiation therapy (RT) on heart function. This study aims to determine RT induced cardiotoxicity in thoracic cancer...

(This article belongs to the Section Cardiovascular Imaging)
  • Review
  • Open Access
1 Citations
1,376 Views
28 Pages

Beyond Angiography: Cardiac CT for Planning Complex PCI in Calcified Coronary Lesions

  • Kenji Sadamatsu,
  • Kazumasa Kurogi,
  • Yasuhiro Nakano and
  • Takashi Kajiya

Coronary artery calcification, present in 20–30% of percutaneous coronary interventions (PCI), significantly impairs procedural success. Conventional angiography detects calcification in fewer than half of affected cases, while intravascular im...

(This article belongs to the Special Issue Celebrate the 10th Anniversary of Tomography)
  • Article
  • Open Access
1,013 Views
11 Pages

Differentiation of Adrenal Adenomas from Non-Adenomatous Lesions: Diagnostic Value of Unenhanced Spectral CT

  • Tommasa Catania,
  • Grazia Morabito,
  • Simone Barbera,
  • Massimo Venturini,
  • Federico Fontana,
  • Eduardo Maccarrone,
  • Grazia Maria Arillotta,
  • Velio Ascenti,
  • Silvio Mazziotti and
  • Giorgio Ascenti
  • + 3 authors

Background: Differentiating adrenal adenomas from non-adenomatous lesions remains a critical challenge in the management of adrenal incidentalomas. Conventional unenhanced CT relies on attenuation thresholds of 10 HU and 20 HU, which present trade-of...

  • Article
  • Open Access
623 Views
13 Pages

Background: Computed tomography (CT) is routinely used to estimate tumor size before lung resection, whereas pathologic examination provides the reference tissue-based measurement after surgery. This study aimed to compare CT-derived and pathologic t...

(This article belongs to the Special Issue Imaging in Cancer Diagnosis)
  • Review
  • Open Access
1,194 Views
43 Pages

The sharp dose gradients that underpin the dosimetric advantage of particle therapy over photon therapy can be undermined by the interplay effects due to intra-fraction motion in modern pencil beam scanning systems. Fluoroscopy-Guided Particle Therap...

(This article belongs to the Special Issue Progress in the Use of Advanced Imaging for Radiation Oncology)
  • Systematic Review
  • Open Access
2 Citations
1,140 Views
24 Pages

Background: Cone Beam Computed Tomography (CBCT) is widely used in image-guided radiotherapy because it provides on-board volumetric imaging at relatively low doses, but its clinical utility for synthetic CT (sCT) generation remains limited by noise,...

(This article belongs to the Special Issue Celebrate the 10th Anniversary of Tomography)
  • Systematic Review
  • Open Access
858 Views
19 Pages

Quantitative Consistency of Amide Proton Transfer-Weighted MRI for Brain Tumor Differentiation: Systematic Review of Clinical Evidence

  • Julius Juhyun Chung,
  • Tianwen Ma,
  • Phaethon Philbrook,
  • Toby Zhou,
  • Adam Ezra Goldman-Yassen and
  • Phillip Zhe Sun

Background/Objectives: Accurate grading of brain gliomas is important, and amide proton transfer-weighted (APTw) MRI shows promise for non-invasive tumor differentiation. This study aimed to perform a comprehensive review and meta-analyses to demonst...

(This article belongs to the Special Issue Celebrate the 10th Anniversary of Tomography)
  • Review
  • Open Access
991 Views
17 Pages

Advances and Challenges in Pharmacokinetic Modeling for PET Imaging: Compartment Models, Input Functions, and Quantitative Techniques

  • James Hao Wang,
  • Meltem Uyanik,
  • Xue Li,
  • Weijie Chen,
  • Zhijin He,
  • Caitlin Randell and
  • Alan McMillan

Pharmacokinetic modeling in Positron Emission Tomography (PET) imaging has become a cornerstone in cancer research, offering insights into tumor development and progression. These models facilitate the quantification of radiotracer distribution and m...

  • Systematic Review
  • Open Access
1,603 Views
20 Pages

The Role of Artificial Intelligence in the Characterization and Outcome Prediction of Prostate Cancer: A Systematic Review

  • Shahd Aljoudi,
  • Aasiya Khan,
  • Iman Dajani,
  • Minatullah Al-Ani,
  • Michael Mina,
  • Dounia Baroudi,
  • Sama Al-Saffar,
  • Souha Aouadi,
  • Tarraf Torfeh and
  • Mohammad S. Yousef
  • + 2 authors

Background/Objectives: Prostate cancer (PCa) is the second most commonly diagnosed cancer in men globally. Radiation oncologists often find PCa tumor characterization and outcome prediction challenging. Therefore, the potential for artificial intelli...

(This article belongs to the Section Artificial Intelligence in Medical Imaging)
  • Article
  • Open Access
1,128 Views
14 Pages

AI-Driven Prediction of Chest CT Radiation Doses: Establishing BMI-Based Diagnostic Reference Levels and Patient–Factor Correlations for Machine-Learning Models

  • Zuhal Y. Hamd,
  • Mohamed Abuzaid,
  • Mohamed Alharbi,
  • Nissren Tamam,
  • Amal I. Alorainy,
  • Lena Alrujaee,
  • Najla Almutairi and
  • Aljouharah Abdullah Alyagoub

Background and aim: Chest CT is a major contributor to population radiation exposure. Conventional, pooled diagnostic reference levels (DRLs) do not account for inter-individual variability in body habitus and are typically used retrospectively. We e...

(This article belongs to the Special Issue Cutting-Edge Applications: Artificial Intelligence and Deep Learning Revolutionizing CT and MRI)
  • Article
  • Open Access
810 Views
16 Pages

Imaging of Artificial Tumor Models in an Anatomical Breast Phantom with a Single-Sided Magnetic Particle Imaging Scanner

  • Christopher McDonough,
  • John Chrisekos,
  • Matthew Jurj,
  • Alycen Wiacek and
  • Alexey Tonyushkin

Background: Magnetic Particle Imaging (MPI) is an emerging biomedical imaging modality that detects superparamagnetic iron oxide nanoparticles (SPIONs), providing high contrast, sensitivity, and quantification capabilities without ionizing radiation,...

(This article belongs to the Section Cancer Imaging)
  • Article
  • Open Access
905 Views
22 Pages

Feasibility and Reliability of an Automated Muscle Segmentation Pipeline Linking Thoracic Supine Kyphosis and Trunk Muscle–Fat% on CT

  • Tianxi Liang,
  • Rian Atri,
  • Sarah Joseph,
  • Yiyuan Shao,
  • Zhitong Zou,
  • Adrian J. Villanueva,
  • Aida Y. Prince,
  • Renke Deng,
  • Kurt Teichman and
  • Martin R. Prince
  • + 1 author

Background: As muscles atrophy, myocytes are replaced by fat and muscle strength diminishes, increasing thoracic supine kyphosis. Here, we investigate the relationship between muscle fat percentage (muscle–fat%) and thoracic supine kyphosis on...

(This article belongs to the Section Artificial Intelligence in Medical Imaging)
XFacebookLinkedIn
Tomography - ISSN 2379-139X