Bioengineering Liver Transplantation II

Dear Colleagues,

The aim of this second Special Issue “Bioengineering Liver Transplantation—Part II” is to understand, review, and evaluate new and exciting opportunities from the field on regenerative medicine, biomaterials, and stem cell research for bioengineering human liver grafts that can be applied for transplantation and personalized treatment of end-stage liver disease.

The development of culture conditions for long-term expansion of liver organoids and induced pluripotent stem cells (iPSC), including novel protocols for hepatocyte and cholangiocyte differentiation, is moving forward, fostering their use in liver tissue engineering.

In this Special Issue, we again welcome reviews and original papers focusing on hepatic cell sources, including adult hepatic stem cells, organoids, fetal and induced pluripotent stem cells, and primary cells (i.e., hepatocytes, cholangiocytes, and endothelial cells) and how these cells can be applied in tissue engineering strategies to generate implantable and personalized liver grafts. Potential topics include but are not limited to liver tissue engineering, liver regeneration, graft repair, liver stem cells and organoids, bioscaffolds, and 3D printing.

We invite you to contribute original research papers, as well as comprehensive reviews, aligned with these themes, to advance and improve the actual state of the art in liver bioengineering and provide new opportunities to solve the imminent medical problem of organ and tissue shortage for transplantation.

Dr. Monique M. A. Verstegen
Prof. Dr. Luc J. W. van der Laan
Dr. Bart Spee
Guest Editors

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