Table of Contents
Toxics, Volume 7, Issue 2 (June 2019) – 18 articles
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Cover Story (view full-size image) Proteins are subject to modification by electrophiles, giving insight into environmental agents and [...] Read more. Proteins are subject to modification by electrophiles, giving insight into environmental agents and endogenous processes that may be contributing factors to chronic human diseases. Untargeted mass spectrometry approaches have been applied to blood proteins hemoglobin and albumin, focusing in particular on the N-terminal residue of hemoglobin and the cysteine-34 in albumin. In the current article, technical developments to detect simultaneously multiple adducts at these sites and then identify them are reviewed, along with recent studies monitoring human exposure to environmental toxicants. These methods have considerable potential for identifying the causes of human chronic disease and identifying individuals at risk. View this paper.