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Toxics, Volume 7, Issue 2

June 2019 - 18 articles

Cover Story: Proteins are subject to modification by electrophiles, giving insight into environmental agents and endogenous processes that may be contributing factors to chronic human diseases. Untargeted mass spectrometry approaches have been applied to blood proteins hemoglobin and albumin, focusing in particular on the N-terminal residue of hemoglobin and the cysteine-34 in albumin. In the current article, technical developments to detect simultaneously multiple adducts at these sites and then identify them are reviewed, along with recent studies monitoring human exposure to environmental toxicants. These methods have considerable potential for identifying the causes of human chronic disease and identifying individuals at risk. View this paper.
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Articles (18)

  • Feature Paper
  • Review
  • Open Access
4 Citations
4,594 Views
18 Pages

25 June 2019

As described elsewhere in this Special Issue on biomarkers, much progress has been made in the detection of modified DNA within organisms at endogenous and exogenous levels of exposure to chemical species, including putative carcinogens and chemother...

  • Article
  • Open Access
21 Citations
4,847 Views
14 Pages

23 June 2019

Bisphenol S (BPS) is a common replacement for bisphenol A (BPA) in plastics, which has resulted in widespread human exposure. Type 1 diabetes (T1D) is an autoimmune disease resulting from pancreatic β-cell destruction and has been increasing in...

  • Article
  • Open Access
13 Citations
5,295 Views
16 Pages

Heavy Metals in Biota in Delaware Bay, NJ: Developing a Food Web Approach to Contaminants

  • Joanna Burger,
  • Nellie Tsipoura,
  • Larry Niles,
  • Amanda Dey,
  • Christian Jeitner and
  • Michael Gochfeld

13 June 2019

Understanding the relationship between heavy metal and selenium levels in biota and their foods is important, but often difficult to determine because animals eat a variety of organisms. Yet such information is critical to managing species population...

  • Article
  • Open Access
26 Citations
5,923 Views
8 Pages

8 June 2019

Infant foods and formulae may contain toxic substances and elements which can be neo-formed contaminants or derived from raw materials or processing. The content of minerals, toxic elements, and hydroxymethylfurfural (HMF) in infant foods and formula...

  • Article
  • Open Access
12 Citations
4,396 Views
7 Pages

Levels of Cadmium in Human Mandibular Bone

  • Andrew W. Browar,
  • Landon L. Leavitt,
  • Walter C. Prozialeck and
  • Joshua R. Edwards

4 June 2019

Cadmium (Cd) is an environmental toxicant that accumulates in bone and alters bone turnover and metabolism. Periodontal disease is characterized by tooth loss and tissue destruction, specifically, loss of supporting bone around the teeth. We have pre...

  • Feature Paper
  • Review
  • Open Access
44 Citations
11,780 Views
35 Pages

Bioanalytical and Mass Spectrometric Methods for Aldehyde Profiling in Biological Fluids

  • Romel P. Dator,
  • Morwena J. Solivio,
  • Peter W. Villalta and
  • Silvia Balbo

4 June 2019

Human exposure to aldehydes is implicated in multiple diseases including diabetes, cardiovascular diseases, neurodegenerative disorders (i.e., Alzheimer’s and Parkinson’s Diseases), and cancer. Because these compounds are strong electroph...

  • Article
  • Open Access
25 Citations
5,236 Views
16 Pages

Quality Indicators and Possible Ecological Risks of Heavy Metals in the Sediments of three Semi-closed East Mediterranean Gulfs

  • Nikolaos Stamatis,
  • Nikolaos Kamidis,
  • Pelagia Pigada,
  • Georgios Sylaios and
  • Emmanouil Koutrakis

29 May 2019

Pollution with copper (Cu), lead (Pb), zinc (Zn), chromium (Cr), and nickel (Ni) heavy metals of the surface sediments collected from three semi-closed East Mediterranean Gulfs, namely Kavala, Strymonikos, and Ierissos Gulfs, North Aegean Sea, Greece...

  • Feature Paper
  • Review
  • Open Access
21 Citations
6,076 Views
17 Pages

25 May 2019

Proteins contain many sites that are subject to modification by electrophiles. Detection and characterisation of these modifications can give insights into environmental agents and endogenous processes that may be contributing factors to chronic huma...

  • Article
  • Open Access
6 Citations
6,039 Views
9 Pages

Antioxidant and Cytoprotective Effect of Piper aduncum L. against Sodium Fluoride (NaF)-Induced Toxicity in Albino Mice

  • Oscar Herrera-Calderon,
  • Luz Chacaltana-Ramos,
  • Ricardo Ángel Yuli-Posadas,
  • Bertha Pari-Olarte,
  • Edwin Enciso-Roca,
  • Johnny Aldo Tinco-Jayo,
  • Juan Pedro Rojas-Armas,
  • Luis Miguel Visitación Felix-Veliz and
  • Cesar Franco-Quino

16 May 2019

Piper aduncum, commonly known as matico, is a plant that grows in the mountainous and coastal regions of Peru, and is studied for its antimicrobial properties and various ethnopharmacological uses. The main objective of this study was to determine th...

  • Feature Paper
  • Review
  • Open Access
11 Citations
6,583 Views
22 Pages

Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science

  • Michael A. Malfatti,
  • Bruce A. Buchholz,
  • Heather A. Enright,
  • Benjamin J. Stewart,
  • Ted J. Ognibene,
  • A. Daniel McCartt,
  • Gabriela G. Loots,
  • Maike Zimmermann,
  • Tiffany M. Scharadin and
  • George D. Cimino
  • + 5 authors

This review summarizes recent developments in radiocarbon tracer technology and applications. Technologies covered include accelerator mass spectrometry (AMS), including conversion of samples to graphite, and rapid combustion to carbon dioxide to ena...

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Toxics - ISSN 2305-6304