Inorganics, Volume 11, Issue 10
2023 October - 44 articles
Cover Story: Two Cu(II) complexes derived from 2,3-substituted quinazolinone Schiff base ligands were prepared and fully characterized via spectroscopic and theoretical methods. Their anticancer activity, evaluated on cancer cell lines (breast—MCF-7, lung—A549) and untransformed cells (keratinocytes—HaCaT), revealed the high cytotoxicity of copper complexes (IC50 in the low micromolar range). Quinazoline ligands remained inactive in inhibiting cell proliferation. Both complexes exhibited enhanced DPPH free radical scavenging efficiency compared to free ligands. An evaluation of oxidative stress in vitro showed reduced production of O2•– and H2O2 after the treatment of cells with copper complexes. Such a negative impact on ROS formation in cells can lead to cellular redox imbalance and subsequent cell death, among other things, by inducing apoptosis and/or necrosis. View this paper
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Inorganics - ISSN 2304-6740