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Children, Volume 12, Issue 4

2025 April - 136 articles

Cover Story: Rapid whole genome sequencing (rWGS) in critically ill infants and children with suspected but undiagnosed genetic diseases can quickly provide precise diagnoses to guide clinical management. This review targets students and clinical practitioners, including non-experts in genetics. It provides a chronological historical overview of key studies that have shaped the progressive development of diagnostic pediatric genomic sequencing and rWGS in pediatric critical care. Essential factors that need to be addressed for widespread rWGS implementation are discussed, including ethical challenges such as informed consent, secondary findings, data privacy concerns, rWGS limitations such as false-positive and false-negative results, variant interpretation challenges, access, costs and reimbursement barriers, and, finally, genomic newborn screening. View this paper
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Articles (136)

  • Article
  • Open Access
3 Citations
2,125 Views
29 Pages

21 April 2025

Background: Obsessive–compulsive disorder (OCD) in youth commonly co-occurs with other affective disorders (e.g., anxiety, depression). Exposure and response prevention (ERP) is the front-line treatment for OCD but may require significant adapt...

  • Review
  • Open Access
1 Citations
1,572 Views
14 Pages

21 April 2025

Background: Up to 33% of individuals with obsessive-compulsive disorder (OCD) have scrupulosity symptoms, although less is known regarding the prevalence rates in youth, specifically. Scrupulosity translates to “fearing sin where there is none&...

  • Article
  • Open Access
2 Citations
1,316 Views
14 Pages

20 April 2025

Background: Oral health is a key indicator of general health, well-being, and quality of life. Sociodemographic factors can affect children’s oral health status. The aim of this study was to analyze the sociodemographic factors that influence t...

  • Systematic Review
  • Open Access
2,269 Views
17 Pages

20 April 2025

Background: Controversy exists about the usefulness of gastric residual (GR) evaluation in preterm infants, and different results have been obtained in studies addressing this practice. Therefore, this meta-analysis aimed to evaluate the efficacy and...

  • Article
  • Open Access
1,635 Views
18 Pages

19 April 2025

Background/Objectives: Over the past three decades, significant progress has been made in understanding the biology of neuroblastoma. The integration of prognostic factors has facilitated risk stratification and the development of targeted treatment...

  • Article
  • Open Access
8 Citations
1,986 Views
13 Pages

Social Affiliation and Attention to Angry Faces in Children: Evidence for the Contributing Role of Parental Sensory Processing Sensitivity

  • Antonios I. Christou,
  • Kostas Fanti,
  • Ioannis Mavrommatis,
  • Georgia Soursou,
  • Pantelis Pergantis and
  • Athanasios Drigas

18 April 2025

Low social affiliation has been described as a phenotypic marker of antisocial behaviors by disrupting children’s initiation and enjoyment of positive physical and emotional connections with others. Laboratory studies have shown that, in early...

  • Case Report
  • Open Access
1 Citations
1,998 Views
12 Pages

Mesenchymal Stem Cell Therapy for Hutchinson–Gilford Progeria: Improvements in Arterial Stiffness and Bone Mineral Density in a Single Case

  • Eun-Young Joo,
  • Ji-Sun Park,
  • Hyun-Tae Shin,
  • Myungji Yoo,
  • Su-Jin Kim,
  • Ji-Eun Lee and
  • Gwang-Seong Choi

18 April 2025

Background/Objectives: Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder that cause premature aging due to LMNA mutations and progerin accumulation. Although lonafarnib, an FDA-approved farnesyltransferase inhibitor, offers...

  • Article
  • Open Access
3,213 Views
22 Pages

ChildWeCare: An Innovative System for the Surveillance and Care of Early Childhood Development Disorders in Thailand

  • Duangkamol Tangviriyapaiboon,
  • Chayut Owatsakul,
  • Patrinee Traisathit,
  • Salinee Thumronglaohapun and
  • Pimwarat Srikummoon

18 April 2025

Background: A structure survey conducted by the Department of Health on early childhood development in Thailand indicates that 27.20–32.50% of preschool children have developmental delays. These children require appropriate care and constant st...

  • Brief Report
  • Open Access
1 Citations
1,076 Views
6 Pages

In Vivo Anatomical Variations in the Lateral Femoral Cutaneous Nerve in Children

  • Lise Langeland Larsen,
  • Line Kjeldgaard Pedersen,
  • Ole Rahbek and
  • Bjarne Møller-Madsen

17 April 2025

Background: The anatomic pathways of the lateral femoral cutaneous nerve (LFCN) have primarily been reported in adult in vitro populations with limited branching patterns. Children with hip disorders may require surgical treatment with an anterior ap...

  • Review
  • Open Access
2,368 Views
13 Pages

17 April 2025

Background/Objectives: Nocturnal enuresis (NE) is a common condition in children, affecting more than 10% of 6-year-olds and typically characterized by involuntary bedwetting during sleep. Although the exact causes remain unclear, ultrasound has emer...

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Children - ISSN 2227-9067