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Children
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Prevention of Cardiovascular Diseases in Children and Adolescents
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Prevention of Cardiovascular Diseases in Children and Adolescents

A special issue of Children (ISSN 2227-9067).

Deadline for manuscript submissions: 25 May 2025 | Viewed by 785

Special Issue Editor

Dr. Felix Sebastian Oberhoffer

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Guest Editor
1. Division of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, Munich, Germany
2. Department of Pediatrics, TUM University Hospital/Munich Municipal Hospital Group, Munich, Germany
Interests: cardiovascular medicine; prevention; pediatrics

Special Issue Information

Dear Colleagues,

We invite you to submit your research to the Special Issue "Prevention of Cardiovascular Diseases in Children and Adolescents" hosted by Children. This Special Issue will focus on early interventions, risk factors, lifestyle changes, and innovative strategies aimed at reducing cardiovascular risk beginning in childhood. Establishing cardiovascular health in young populations is crucial to improving long-term outcomes. We welcome a wide range of studies in epidemiology, clinical research, public health, behavioral sciences, and translational research. By gathering global insights and evidence-based approaches, this Special Issue seeks to support health practitioners, researchers, and policymakers in developing effective strategies to promote cardiovascular health in children and adolescents.

Dr. Felix Sebastian Oberhoffer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prevention
  • cardiovascular medicine
  • pediatrics

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

16 pages, 1355 KiB  
Article
Plasma Calmodulin as a Biomarker of Subclinical Cardiovascular Disease in Pediatric Chronic Kidney Disease
by Hsin-Jung Lee, Wei-Ting Liao, Chien-Ning Hsu, You-Lin Tain and Pei-Chen Lu
Children 2025, 12(5), 599; https://doi.org/10.3390/children12050599 - 4 May 2025
Viewed by 170
Abstract
Background: Calmodulin is a calcium-signaling protein implicated in cardiac remodeling and could be released extracellularly. It was previously identified as differentially expressed in hypertensive pediatric chronic kidney disease (CKD). This study assessed plasma calmodulin as a cardiovascular disease (CVD) biomarker in pediatric CKD [...] Read more.
Background: Calmodulin is a calcium-signaling protein implicated in cardiac remodeling and could be released extracellularly. It was previously identified as differentially expressed in hypertensive pediatric chronic kidney disease (CKD). This study assessed plasma calmodulin as a cardiovascular disease (CVD) biomarker in pediatric CKD and compared it with traditional risk markers. Methods: We conducted a cross-sectional study of 81 children with CKD aged 3–18 years. All underwent clinical assessments and echocardiography; 44 had carotid ultrasound, and 38 completed ambulatory blood pressure monitoring (ABPM). Results: Most participants had preserved renal function (median eGFR, 104.4 mL/min/1.73 m2). Plasma calmodulin levels were significantly associated with early markers of CVD, including interventricular septal thickness, left ventricular mass, carotid intima–media thickness, and ABPM systolic measures (all r > 0.2; p < 0.05). In multivariable analysis, only calmodulin and office systolic blood pressure (BP) independently predicted abnormal BP profiles. Conclusions: Plasma calmodulin may serve as a sensitive, though non-specific, early CVD biomarker in pediatric CKD and could complement conventional screening tools. Full article
(This article belongs to the Special Issue Prevention of Cardiovascular Diseases in Children and Adolescents)
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11 pages, 227 KiB  
Article
Twenty-Four Hour Ambulatory Blood Pressure Monitoring in Offspring Conceived Through Assisted Reproductive Technologies
by Felix Sebastian Oberhoffer, Pengzhu Li, Magdalena Langer, Theresa Vilsmaier, Marie Kramer, Franziska Sciuk, Brenda Kolbinger, André Jakob, Nina Rogenhofer, Robert Dalla-Pozza, Christian Thaler and Nikolaus Alexander Haas
Children 2025, 12(4), 507; https://doi.org/10.3390/children12040507 - 15 Apr 2025
Viewed by 249
Abstract
Background: One in fifty infants is conceived through assisted reproductive technologies (ART). To date, data on the cardiovascular morbidity of ART individuals is ambiguous. This study investigated the vascular function of young ART subjects using 24 hour ambulatory blood pressure monitoring (24 h [...] Read more.
Background: One in fifty infants is conceived through assisted reproductive technologies (ART). To date, data on the cardiovascular morbidity of ART individuals is ambiguous. This study investigated the vascular function of young ART subjects using 24 hour ambulatory blood pressure monitoring (24 h ABPM). Methods: ART subjects and spontaneously conceived controls matched in age as well as sex were enrolled. A 24 h blood pressure profile including pulse wave analysis was executed in all study participants. Blood pressure readings were assessed every 15 min during daytime and every 30 min during nighttime. The 24 h systolic/diastolic blood pressure (SBP/DBP) as well as central blood pressure, nocturnal blood pressure decrease, and 24 h pulse wave velocity (PWV) were analyzed. Results: A total of 41 ART individuals and 46 spontaneously conceived peers were included in the final analysis (mean age: 15.37 ± 5.46 years vs. 16.48 ± 5.23 years, p = 0.338). The 24 h SBP (112.74 ± 9.24 mmHg vs. 112.73 ± 6.70 mmHg, p = 0.997), 24 h DBP (65.61 ± 7.98 mmHg vs. 66.57 ± 7.03 mmHg, p = 0.550), 24 h central blood pressure, nocturnal blood pressure decrease, and 24 h PWV did not demonstrate significant differences between the ART and control group. Conclusions: In contrast to previous studies, no significant differences in 24 h blood pressure were demonstrated between ART subjects and spontaneously conceived peers. Hence, the results of this study do not indicate an unfavorable blood pressure profile in ART offspring. Larger multi-centric studies are needed to validate these results in the future. Full article
(This article belongs to the Special Issue Prevention of Cardiovascular Diseases in Children and Adolescents)
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