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Biomedicines, Volume 8, Issue 10

October 2020 - 72 articles

Cover Story: Reverse cholesterol transport from peripheral tissues to the liver is a major atheroprotective event, with cholesterol efflux as a rate-limiting step. Nanoparticles mimicking natural HDL (rHDL) have been used in several clinical trials for cardiovascular disease therapy to remove cholesterol excess. Here, we show that rHDLs with lipid composition similar to nascent HDL are more efficient in promoting cholesterol efflux, and their physical characteristics should be taken into consideration to design more efficient rHDL to be used as cholesterol efflux promoting particles. View this paper
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Articles (72)

  • Article
  • Open Access
4 Citations
3,060 Views
14 Pages

Effect of Gosha-Jinki-Gan on Levels of Specific mRNA Transcripts in Mouse Testes after Busulfan Treatment

  • Ning Qu,
  • Kenta Nagahori,
  • Miyuki Kuramasu,
  • Yuki Ogawa,
  • Kaori Suyama,
  • Shogo Hayashi,
  • Kou Sakabe and
  • Masahiro Itoh

With the increase in survival rates of cancer patients in recent years, infertility caused by anticancer treatments has become a significant concern for cancer survivors. Some studies have suggested that Sertoli cells play a key role in mediating tes...

  • Review
  • Open Access
38 Citations
5,815 Views
17 Pages

PPARα Agonist Oral Therapy in Diabetic Retinopathy

  • Yohei Tomita,
  • Deokho Lee,
  • Kazuo Tsubota and
  • Toshihide Kurihara

Diabetic retinopathy (DR) is an eye condition that develops after chronically poorly-managed diabetes, and is presently the main cause for blindness on a global scale. Current treatments for DR such as laser photocoagulation, topical injection of cor...

  • Article
  • Open Access
15 Citations
11,770 Views
11 Pages

Astaxanthin (AXT) is a xanthophyll carotenoid known to have potent anti-cancer effects via upregulation of the intracellular reactive oxygen species (ROS) levels, which triggers apoptosis of cancer cells. While several studies have shown that AXT has...

  • Article
  • Open Access
20 Citations
3,828 Views
12 Pages

CRP Is Transported by Monocytes and Monocyte-Derived Exosomes in the Blood of Patients with Coronary Artery Disease

  • Ivan Melnikov,
  • Sergey Kozlov,
  • Olga Saburova,
  • Ekaterina Zubkova,
  • Olga Guseva,
  • Sergey Domogatsky,
  • Tatiana Arefieva,
  • Natalia Radyukhina,
  • Maria Zvereva and
  • Yuliya Avtaeva
  • + 2 authors

The objective of this work was to study the ability of blood cells and their microparticles to transport monomeric and pentameric forms of C-reactive protein (mCRP and pCRP) in the blood of patients with coronary artery disease (CAD). Blood was obtai...

  • Article
  • Open Access
26 Citations
5,443 Views
16 Pages

CO2 laser manufacturing has served as an enabling and reliable tool for rapid and cost-effective microfabrication over the past few decades. While a wide range of industrial and biological applications have been studied, the choice of materials fabri...

  • Review
  • Open Access
63 Citations
7,607 Views
30 Pages

Hypoxia plays an important role in the development of many infectious, inflammatory, and tumor diseases. The predisposition to such disorders is mostly provided by differences in basic tolerance to oxygen deficiency, which we discuss in this review....

  • Article
  • Open Access
15 Citations
4,156 Views
16 Pages

Rheological Properties and Growth Factors Content of Platelet-Rich Plasma: Relevance in Veterinary Biomedical Treatments

  • Diego Romano Perinelli,
  • Giulia Bonacucina,
  • Stefania Pucciarelli,
  • Marco Cespi,
  • Evelina Serri,
  • Valeria Polzonetti,
  • Adolfo Maria Tambella and
  • Silvia Vincenzetti

Platelet-rich plasma (PRP) is a nontransfusional hemocomponent, considered as a powerful concentrate of growth factors (GFs) therapeutically used to stimulate tissue regeneration. The use of autologous PRP, as the patient’s own biological mater...

  • Article
  • Open Access
10 Citations
3,225 Views
18 Pages

Fetal Undernutrition Induces Resistance Artery Remodeling and Stiffness in Male and Female Rats Independent of Hypertension

  • Perla Y. Gutiérrez-Arzapalo,
  • Pilar Rodríguez-Rodríguez,
  • David Ramiro-Cortijo,
  • Marta Gil-Ortega,
  • Beatriz Somoza,
  • Ángel Luis López de Pablo,
  • Maria del Carmen González and
  • Silvia M. Arribas

Fetal undernutrition programs hypertension and cardiovascular diseases, and resistance artery remodeling may be a contributing factor. We aimed to assess if fetal undernutrition induces resistance artery remodeling and the relationship with hypertens...

  • Article
  • Open Access
23 Citations
5,272 Views
27 Pages

Development of a Multifunctional Bioerodible Nanocomposite Containing Metronidazole and Curcumin to Apply on L-PRF Clot to Promote Tissue Regeneration in Dentistry

  • Denise Murgia,
  • Giuseppe Angellotti,
  • Alice Conigliaro,
  • Francesco Carfi Pavia,
  • Fabio D'Agostino,
  • Marco Contardi,
  • Rodolfo Mauceri,
  • Riccardo Alessandro,
  • Giuseppina Campisi and
  • Viviana De Caro

Teeth extractions are often followed by alveolar bone reabsorption, although an adequate level of bone is required for reliable rehabilitations by dental implants. Leukocyte and platelet-rich fibrin (L-PRF) has been widely applied in regenerative pro...

  • Article
  • Open Access
6 Citations
5,600 Views
22 Pages

Engineering and Preclinical Evaluation of Western Reserve Oncolytic Vaccinia Virus Expressing A167Y Mutant Herpes Simplex Virus Thymidine Kinase

  • S. M. Bakhtiar UL Islam,
  • Young Mi Hong,
  • Mefotse saha Cyrelle Ornella,
  • Daniel Ngabire,
  • Hyunjung Jang,
  • Euna Cho,
  • Eung-Kyun Kim,
  • Jessye Jin Joo Hale,
  • Cy Hyun Kim and
  • Soon Cheol Ahn
  • + 2 authors

Viral replication of thymidine kinase deleted (tk−) vaccinia virus (VV) is attenuated in resting normal cells, enabling cancer selectivity, however, replication potency of VV-tk− appears to be diminished in cancer cells. Previously, we fo...

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Biomedicines - ISSN 2227-9059