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Article

Obesity Augments Glucocorticoid-Dependent Muscle Atrophy in Male C57BL/6J Mice

1
Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
2
Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38103, USA
3
Adipocyte Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70803, USA
4
Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
5
Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38103, USA
*
Author to whom correspondence should be addressed.
Biomedicines 2020, 8(10), 420; https://doi.org/10.3390/biomedicines8100420
Received: 17 August 2020 / Revised: 25 September 2020 / Accepted: 7 October 2020 / Published: 15 October 2020
(This article belongs to the Special Issue Glucocorticoid Receptor Function in Metabolic Diseases)
Glucocorticoids promote muscle atrophy by inducing a class of proteins called atrogenes, resulting in reductions in muscle size and strength. In this work, we evaluated whether a mouse model with pre-existing diet-induced obesity had altered glucocorticoid responsiveness. We observed that all animals treated with the synthetic glucocorticoid dexamethasone had reduced strength, but that obesity exacerbated this effect. These changes were concordant with more pronounced reductions in muscle size, particularly in Type II muscle fibers, and potentiated induction of atrogene expression in the obese mice relative to lean mice. Furthermore, we show that the reductions in lean mass do not fully account for the dexamethasone-induced insulin resistance observed in these mice. Together, these data suggest that obesity potentiates glucocorticoid-induced muscle atrophy. View Full-Text
Keywords: glucocorticoids; atrophy; obesity; atrogenes; insulin resistance glucocorticoids; atrophy; obesity; atrogenes; insulin resistance
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MDPI and ACS Style

Gunder, L.C.; Harvey, I.; Redd, J.R.; Davis, C.S.; AL-Tamimi, A.; Brooks, S.V.; Bridges, D. Obesity Augments Glucocorticoid-Dependent Muscle Atrophy in Male C57BL/6J Mice. Biomedicines 2020, 8, 420. https://doi.org/10.3390/biomedicines8100420

AMA Style

Gunder LC, Harvey I, Redd JR, Davis CS, AL-Tamimi A, Brooks SV, Bridges D. Obesity Augments Glucocorticoid-Dependent Muscle Atrophy in Male C57BL/6J Mice. Biomedicines. 2020; 8(10):420. https://doi.org/10.3390/biomedicines8100420

Chicago/Turabian Style

Gunder, Laura C., Innocence Harvey, JeAnna R. Redd, Carol S. Davis, Ayat AL-Tamimi, Susan V. Brooks, and Dave Bridges. 2020. "Obesity Augments Glucocorticoid-Dependent Muscle Atrophy in Male C57BL/6J Mice" Biomedicines 8, no. 10: 420. https://doi.org/10.3390/biomedicines8100420

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