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Article

Distinct Features of Autoimmune Gastritis in Patients with Open-Type Chronic Gastritis in Japan

1
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan
2
Division of Advanced Genome Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo 108-863, Japan
3
Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan
*
Author to whom correspondence should be addressed.
Biomedicines 2020, 8(10), 419; https://doi.org/10.3390/biomedicines8100419
Received: 18 September 2020 / Revised: 5 October 2020 / Accepted: 12 October 2020 / Published: 14 October 2020
(This article belongs to the Special Issue Gastrointestinal Cancer Research: From Basic Science to the Clinic)
In Asia, the incidences of Helicobacter pylori infection and gastric cancer are high, but their association with autoimmune gastritis (AIG) is unclear. This was a retrospective cohort study of patients endoscopically diagnosed with chronic gastritis between 2005 and 2017. AIG was diagnosed according to anti-parietal cell antibody positivity. Laboratory, histological findings, and gastric cancer incidence were compared between AIG and non-AIG patients. The AIG group had more females and a higher rate of thyroid disease. Serum levels of gastrin were significantly higher in AIG patients (mean 1412 and 353 pg/mL, p < 0.001). The endoscopic findings included a significantly higher percentage of corpus-dominant atrophy in AIG (31.67%) than in non-AIG (7.04%) patients (p < 0.001). Clusters of ECL cells were observed in 28% of AIG patients and 7% of non-AIG patients (p = 0.032). The cumulative incidence of gastric cancer at 5 and 10 years was 0% and 0.03% in the AIG group and 0.03% and 0.05% in the non-AIG group, and no significant difference in gastric cancer incidence was observed. Despite significant differences in gastrin levels between AIG and non-AIG patients, there was no evidence of an impact of AIG on the incidence of gastric cancer. View Full-Text
Keywords: gastritis; atrophy; microbiota; helicobacter infections; autoimmune diseases gastritis; atrophy; microbiota; helicobacter infections; autoimmune diseases
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MDPI and ACS Style

Tsuboi, M.; Niikura, R.; Hayakawa, Y.; Hirata, Y.; Ushiku, T.; Koike, K. Distinct Features of Autoimmune Gastritis in Patients with Open-Type Chronic Gastritis in Japan. Biomedicines 2020, 8, 419. https://doi.org/10.3390/biomedicines8100419

AMA Style

Tsuboi M, Niikura R, Hayakawa Y, Hirata Y, Ushiku T, Koike K. Distinct Features of Autoimmune Gastritis in Patients with Open-Type Chronic Gastritis in Japan. Biomedicines. 2020; 8(10):419. https://doi.org/10.3390/biomedicines8100419

Chicago/Turabian Style

Tsuboi, Mayo, Ryota Niikura, Yoku Hayakawa, Yoshihiro Hirata, Tetsuo Ushiku, and Kazuhiko Koike. 2020. "Distinct Features of Autoimmune Gastritis in Patients with Open-Type Chronic Gastritis in Japan" Biomedicines 8, no. 10: 419. https://doi.org/10.3390/biomedicines8100419

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