Biomedicines, Volume 8, Issue 11 (November 2020) – 86 articles
Cover Story (view full-size image): Tumor stroma mainly consists of cancer-associated fibroblasts, extracellular matrix, vasculature, and tumor-associated macrophages. These components all exert key roles in tumor progression, emphasizing their relevance to cancer therapy design. The multifaceted oncolytic viruses (OVs) represent a promising therapeutic platform to overcome the dense stromal tissue. Inherent and genetically modified OVs can directly target both stromal components and tumor cells, facilitating OV penetration, tumor regression, and anti-tumor immune activity. View this paper
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